The Tyr ( albino ) locus of the laboratory mouse

The albino mouse was already known in ancient times and was apparently selectively bred in Egypt, China, and Japan. Thus, it is not surprising that the c or albino locus (now the Tyr locus) was among the first used to demonstrate Mendelian inheritance in mammals at the dawn of the past century. This locus is now known to encode tyrosinase, the rate-limiting enzyme in the production of melanin pigment, and the molecular basis of the albino (Tyr c ) mutation is known. Here we describe the congenic series of Tyr-locus alleles, from wild type to null (albino). We compare eye and skin pigmentation phenotypes and the genetic lesions that cause each. We suggest that this panel of congenic mutants contains rich, untapped resources for the study of many questions of basic cell biological interes

The Casimir Problem of Spherical Dielectrics: Quantum Statistical and Field Theoretical Approaches

The Casimir free energy for a system of two dielectric concentric nonmagnetic spherical bodies is calculated with use of a quantum statistical mechanical method, at arbitrary temperature. By means of this rather novel method, which turns out to be quite powerful (we have shown this to be true in other situations also), we consider first an explicit evaluation of the free energy for the static case, corresponding to zero Matsubara frequency ($n=0$). Thereafter, the time-dependent case is examined. For comparison we consider the calculation of the free energy with use of the more commonly known field theoretical method, assuming for simplicity metallic boundary surfaces.Comment: 31 pages, LaTeX, one new reference; version to appear in Phys. Rev.

Unlocked Childhood

Photo of a red/brown-colored door with sunlight shining on it

Feasibility of trial procedures for a randomised controlled trial of a community based group exercise intervention for falls prevention for visually impaired older people: the VIOLET study

Background Visually impaired older people (VIOP) have a higher risk of falling than their sighted peers, and are likely to avoid physical activity. The aim was to adapt the existing Falls Management Exercise (FaME) programme for VIOP, delivered in the community, and to investigate the feasibility of conducting a definitive randomised controlled trial (RCT) of this adapted intervention. Methods Two-centre randomised mixed methods pilot trial and economic evaluation of the adapted group-based FaME programme for VIOP versus usual care. A one hour exercise programme ran weekly over 12 weeks at the study sites (Newcastle and Glasgow), delivered by third sector (voluntary and community) organisations. Participants were advised to exercise at home for an additional two hours over the week. Those randomised to the usual activities group received no intervention. Outcome measures were completed at baseline, 12 and 24 weeks. The potential primary outcome was the Short Form Falls Efficacy Scale – International (SFES-I). Participants’ adherence was assessed by reviewing attendance records and self-reported compliance to the home exercises. Adherence with the course content (fidelity) by instructors was assessed by a researcher. Adverse events were collected in a weekly phone call. Results Eighteen participants, drawn from community-living VIOP were screened; 68 met the inclusion criteria; 64 participants were randomised with 33 allocated to the intervention and 31 to the usual activities arm. 94% of participants provided data at the 12 week visit and 92% at 24 weeks. Adherence was high. The intervention was found to be safe with 76% attending nine or more classes. Median time for home exercise was 50 min per week. There was little or no evidence that fear of falling, balance and falls risk, physical activity, emotional, attitudinal or quality of life outcomes differed between trial arms at follow-up. Conclusions The intervention, FaME, was implemented successfully for VIOP and all progression criteria for a main trial were met. The lack of difference between groups on fear of falling was unsurprising given it was a pilot study but there may have been other contributory factors including suboptimal exercise dose and apparent low risk of falls in participants. These issues need addressing for a future trial

Competitive development: economic development and the inquiry into power relations in Missouri

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.Title from title screen of research.pdf file viewed on (June 26, 2007)Includes bibliographical references.Thesis (M.A.) University of Missouri-Columbia 2006.Dissertations, Academic -- University of Missouri--Columbia -- Sociology.Economic development policy is an important topic for legislatures across the country. The contemporary trend of economic development policy has spread throughout the country in response to the political and economic changes of the last 30 years. A side effect of this focus has been the increased competition for investment between individual states and also between the various municipalities inside the states. Economic development policy is a tool that signifies a change in power relations and larger social structures. The expressed purpose of this thesis project is to highlight how the use of economic development policy has adjusted to larger national and international changes in private, political and economic organization. This work will utilize a case study methodology which focuses on the state of Missouri, while looking to place the state in a larger context outlined in Gordon, Edwards & Reich's Social Structures of Accumulation Thesis (1982/Wallace & Brady extension 2001). The main contention derived from this thesis is that economic development policies are social structures of accumulation that have become institutionalized because of macro-level changes in the economic and political environment. This work will highlight how the emphasis of location, business climate and public/private cooperation are all outgrowths of this contemporary trend

Scientists’ Warning on the Problem with Overpopulation and Living Systems

A biological system can be defined as a collection of interacting elements, organised together with a common function(s). This framework can provide valuable insights into the problematic interactions between humanity and the rest of life on earth. Life is composed of a nested hierarchy of systems, united into a vastly complex, global system of ecosystems, the biosystem. The function of the biosystem and its components is the sustainable reproduction and evolution of life. Humans have many of their own systems, including a global, commercially oriented system of corporations and social structures, which we term the corposystem. A major aim of the corposystem is endless growth for profit, which depends on endless human population growth: not sustainable on a finite planet. These two global systems are clearly in direct conflict. To preserve the biosystem, including humanity, we must align the corposystem ethic with the reality of the biosystem’s needs

Assessing the congruence of thermal niche estimations derived from distribution and physiological data. A test using diving beetles.

A basic aim of ecology is to understand the determinants of organismal distribution, the niche concept and species distribution models providing key frameworks to approach the problem. As temperature is one of the most important factors affecting species distribution, the estimation of thermal limits is crucially important for inferring range constraints. It is expectable that thermal physiology data derived from laboratory experiments and species' occurrences may express different aspects of the species' niche. However, there is no study systematically testing this prediction in a given taxonomic group while controlling by potential phylogenetic inertia. We estimate the thermal niches of twelve Palaearctic diving beetles species using physiological data derived from experimental analyses in order to examine the extent to which these coincided with those estimated from distribution models based on observed occurrences. We found that thermal niche estimates derived from both approaches lack general congruence, and these results were similar before and after controlling by phylogeny. The congruence between potential distributions obtained from the two different procedures was also explored, and we found again that the percentage of agreement were not very high (~60%). We confirm that both thermal niche estimates derived from geographical and physiological data are likely to misrepresent the true range of climatic variation that these diving beetles are able to tolerate, and so these procedures could be considered as incomplete but complementary estimations of an inaccessible reality

Biogeography at the limits of life: Do extremophilic microbial communities show biogeographical regionalization?

Aim Biogeographical regions are the fundamental geographical units for grouping Earth's biodiversity. Biogeographical regionalization has been demonstrated for many higher taxa, such as terrestrial plants and vertebrates, but not in microbial communities. Therefore, we sought to test empirically whether microbial communities, or taxa, show patterns consistent with biogeographical regionalization. Location Within halite (NaCl) crystals from coastal solar salterns of western Europe, the Mediterranean and east Africa. Time period Modern (2006–2013). Major taxa studied Archaea. Methods Using high-throughput Illumina amplicon sequencing, we generated the most high-resolution characterization of halite-associated archaeal communities to date, using samples from 17 locations. We grouped communities into biogeographical clusters based on community turnover to test whether these communities show biogeographical regionalization. To examine whether individual taxa, rather than communities, show biogeographical patterns, we also tested whether the relative abundance of individual genera may be indicative of a community's biogeographical origins using machine learning methods, specifically random forest classification. Results We found that the rate of community turnover was greatest over subregional spatial scales (< 500 km), whereas at regional spatial scales the turnover was independent of geographical distance. Biogeographical clusters of communities were either not statistically robust or lacked spatial coherence, inconsistent with biogeographical regionalization. However, we identified several archaeal genera that were good indicators of biogeographical origin, providing classification error rates of < 10%. Main conclusions Overall, our results provide little support for the concept of biogeographical regions in these extremophilic microbial communities, despite the fact that some taxa do show biogeographical patterns. We suggest that variable dispersal ability among the halite-associated Archaea may disrupt biogeographical patterns at the community level, preventing the formation of biogeographical regions. This means that the processes that lead to the formation of biogeographical regions operate differentially on individual microbial taxa rather than on entire communities