On classical string configurations

Equations which define classical configurations of strings in $R^3$ are presented in a simple form. General properties as well as particular classes of solutions of these equations are considered.Comment: 10 pages, Latex, no figures, trivial corrections, submitted to Modern Physics Letters

Incidence and public health burden of sunburn among beachgoers in the United States.

The beach environment creates many barriers to effective sun protection, putting beachgoers at risk for sunburn, a well-established risk factor for skin cancer. Our objective was to estimate incidence of sunburn among beachgoers and evaluate the relationship between sunburn incidence and sun-protective behaviors. A secondary analysis, of prospective cohorts at 12 locations within the U.S. from 2003 to 2009 (n = 75,614), were pooled to evaluate sunburn incidence 10-12 days after the beach visit. Behavioral and environmental conditions were cross-tabulated with sunburn incidence. Multivariable logistic regression was used to estimate the association between new sunburn and sun-protective behaviors. Overall, 13.1% of beachgoers reported sunburn. Those aged 13-18 years (16.5%), whites (16.0%), and those at beach locations along the Eastern Seaboard (16.1%), had the highest incidence of sunburn. For those spending ≥5 h in the sun, the use of multiple types of sun protection reduced odds of sunburn by 55% relative to those who used no sun protection (Odds Ratio = 0.45 (95% Confidence Interval:0.27-0.77)) after adjusting for skin type, age, and race. Acute health effects of sunburn tend to be mild and self-limiting, but potential long-term health consequences are more serious and costly. Efforts to encourage and support proper sun-protective behaviors, and increase access to shade, protective clothing, and sunscreen, can help prevent sunburn and reduce skin cancer risk among beachgoers

Milne-Eddington inversion of the Fe I line pair at 630~nm

The iron lines at 630.15 and 630.25 nm are often used to determine the physical conditions of the solar photosphere. A common approach is to invert them simultaneously under the Milne-Eddington approximation. The same thermodynamic parameters are employed for the two lines, except for their opacities, which are assumed to have a constant ratio. We aim at investigating the validity of this assumption, since the two lines are not exactly the same. We use magnetohydrodynamic simulations of the quiet Sun to examine the behavior of the ME thermodynamic parameters and their influence on the retrieval of vector magnetic fields and flow velocities. Our analysis shows that the two lines can be coupled and inverted simultaneously using the same thermodynamic parameters and a constant opacity ratio. The inversion of two lines is significantly more accurate than single-line inversions because of the larger number of observables.Comment: Accepted for publication in Astronomy and Astrophysics (Research Note

PCA detection and denoising of Zeeman signatures in stellar polarised spectra

Our main objective is to develop a denoising strategy to increase the signal to noise ratio of individual spectral lines of stellar spectropolarimetric observations. We use a multivariate statistics technique called Principal Component Analysis. The cross-product matrix of the observations is diagonalized to obtain the eigenvectors in which the original observations can be developed. This basis is such that the first eigenvectors contain the greatest variance. Assuming that the noise is uncorrelated a denoising is possible by reconstructing the data with a truncated basis. We propose a method to identify the number of eigenvectors for an efficient noise filtering. Numerical simulations are used to demonstrate that an important increase of the signal to noise ratio per spectral line is possible using PCA denoising techniques. It can be also applied for detection of magnetic fields in stellar atmospheres. We analyze the relation between PCA and commonly used well-known techniques like line addition and least-squares deconvolution. Moreover, PCA is very robust and easy to compute.Comment: accepted to be published in A&

Unified Treatment of Heterodyne Detection: the Shapiro-Wagner and Caves Frameworks

A comparative study is performed on two heterodyne systems of photon detectors expressed in terms of a signal annihilation operator and an image band creation operator called Shapiro-Wagner and Caves' frame, respectively. This approach is based on the introduction of a convenient operator $\hat \psi$ which allows a unified formulation of both cases. For the Shapiro-Wagner scheme, where $[\hat \psi, \hat \psi^{\dag}] =0$, quantum phase and amplitude are exactly defined in the context of relative number state (RNS) representation, while a procedure is devised to handle suitably and in a consistent way Caves' framework, characterized by $[\hat \psi, \hat \psi^{\dag}] \neq 0$, within the approximate simultaneous measurements of noncommuting variables. In such a case RNS phase and amplitude make sense only approximately.Comment: 25 pages. Just very minor editorial cosmetic change

Atomic alignment and Diagnostics of Magnetic Fields in Diffuse Media

We continue our studies of atomic alignment in diffuse media, in particularly, in interstellar and circumstellar media, with the goal of developing new diagnostics of magnetic fields in these environments. We understand atomic alignment as alignment of atoms or ions in their ground state. Such atoms are sensitive to weak magnetic fields. In particular, we provide predictions of the polarization that arises from astrophysically important aligned atoms (ions) with fine structure of the ground level, namely, OI and SII and Ti II. Unlike our earlier papers which dealt with weak fields only, a substantial part of our current paper is devoted to the studies of atomic alignment when magnetic fields get strong enough to affect the emission from the excited level, i.e. with the regime when the magnetic splitting is comparable to the line-width. This is a regime of Hanle effect modified by the atomic alignment. Using an example of emission and absorption lines of SII ion we demonstrate how polarimetric studies can probe magnetic fields in circumstellar regions and accretion disks. In addition, we show that atomic alignment induced by anisotropic radiation can induce substantial variations of magnetic dipole transitions within the ground state, thus affecting abundance studies based on this emission. Moreover, the radio emission is polarized, provides a new way to study magnetic fields, e.g. at the epoch of Universe reionization.Comment: Minor changes, accepted to Ap

Extended thromboprophylaxis with betrixaban in acutely ill medical patients

BACKGROUND: Patients with acute medical illnesses are at prolonged risk for venous thrombosis. However, the appropriate duration of thromboprophylaxis remains unknown. METHODS: Patients who were hospitalized for acute medical illnesses were randomly assigned to receive subcutaneous enoxaparin (at a dose of 40 mg once daily) for 10±4 days plus oral betrixaban placebo for 35 to 42 days or subcutaneous enoxaparin placebo for 10±4 days plus oral betrixaban (at a dose of 80 mg once daily) for 35 to 42 days. We performed sequential analyses in three prespecified, progressively inclusive cohorts: patients with an elevated d-dimer level (cohort 1), patients with an elevated d-dimer level or an age of at least 75 years (cohort 2), and all the enrolled patients (overall population cohort). The statistical analysis plan specified that if the between-group difference in any analysis in this sequence was not significant, the other analyses would be considered exploratory. The primary efficacy outcome was a composite of asymptomatic proximal deep-vein thrombosis and symptomatic venous thromboembolism. The principal safety outcome was major bleeding. RESULTS: A total of 7513 patients underwent randomization. In cohort 1, the primary efficacy outcome occurred in 6.9% of patients receiving betrixaban and 8.5% receiving enoxaparin (relative risk in the betrixaban group, 0.81; 95% confidence interval [CI], 0.65 to 1.00; P=0.054). The rates were 5.6% and 7.1%, respectively (relative risk, 0.80; 95% CI, 0.66 to 0.98; P=0.03) in cohort 2 and 5.3% and 7.0% (relative risk, 0.76; 95% CI, 0.63 to 0.92; P=0.006) in the overall population. (The last two analyses were considered to be exploratory owing to the result in cohort 1.) In the overall population, major bleeding occurred in 0.7% of the betrixaban group and 0.6% of the enoxaparin group (relative risk, 1.19; 95% CI, 0.67 to 2.12; P=0.55). CONCLUSIONS: Among acutely ill medical patients with an elevated d-dimer level, there was no significant difference between extended-duration betrixaban and a standard regimen of enoxaparin in the prespecified primary efficacy outcome. However, prespecified exploratory analyses provided evidence suggesting a benefit for betrixaban in the two larger cohorts. (Funded by Portola Pharmaceuticals; APEX ClinicalTrials.gov number, NCT01583218.)

Two-dimensional solar spectropolarimetry with the KIS/IAA Visible Imaging Polarimeter

Spectropolarimetry at high spatial and spectral resolution is a basic tool to characterize the magnetic properties of the solar atmosphere. We introduce the KIS/IAA Visible Imaging Polarimeter (VIP), a new post-focus instrument that upgrades the TESOS spectrometer at the German VTT into a full vector polarimeter. VIP is a collaboration between the KIS and the IAA. We describe the optical setup of VIP, the data acquisition procedure, and the calibration of the spectropolarimetric measurements. We show examples of data taken between 2005 and 2008 to illustrate the potential of the instrument. VIP is capable of measuring the four Stokes profiles of spectral lines in the range from 420 to 700 nm with a spatial resolution better than 0.5". Lines can be sampled at 40 wavelength positions in 60 s, achieving a noise level of about 2 x 10E-3 with exposure times of 300 ms and pixel sizes of 0.17" x 0.17" (2 x 2 binning). The polarization modulation is stable over periods of a few days, ensuring high polarimetric accuracy. The excellent spectral resolution of TESOS allows the use of sophisticated data analysis techniques such as Stokes inversions. One of the first scientific results of VIP presented here is that the ribbon-like magnetic structures of the network are associated with a distinct pattern of net circular polarization away from disk center. VIP performs spectropolarimetric measurements of solar magnetic fields at a spatial resolution that is only slightly worse than that of the Hinode spectropolarimeter, while providing a 2D field field of view and the possibility to observe up to four spectral regions sequentially with high cadence. VIP can be used as a stand-alone instrument or in combination with other spectropolarimeters and imaging systems of the VTT for extended wavelength coverage.Comment: 10 pages, 8 figures, accepted by Astronomy and Astrophysics v2: figures updated with improved qualit

Tackling tuberculosis: insights from an international TB Summit in London

Tuberculosis (TB) poses a grave predicament to the world as it is not merely a scientific challenge but a socio-economic burden as well. A prime cause of mortality in human due to an infectious disease; the malady and its cause, Mycobacterium tuberculosis have remained an enigma with many questions that remain unanswered. The ability of the pathogen to survive and switch between varied physiological states necessitates a protracted therapeutic regimen that exerts an excessive strain on low-resource countries. To complicate things further, there has been a significant rise of antimicrobial resistance. Existing control measures, including treatment regimens have remained fairly uniform globally for at least half a century and require reinvention. Overcoming the societal and scientific challenges requires an increase in dialog to identify key regions that need attention and effective partners with whom successful collaborations can be fostered. In this report, we explore the discussions held at the International TB Summit 2015 hosted by EuroSciCon, which served as an excellent platform for researchers to share their recent findings. Ground-breaking results require outreach to affect policy design, governance and control of the disease. Hence, we feel it is important that meetings such as these reach a wider, global audience

Optimal Dorfman Group Testing For Symmetric Distributions

We study Dorfman's classical group testing protocol in a novel setting where individual specimen statuses are modeled as exchangeable random variables. We are motivated by infectious disease screening. In that case, specimens which arrive together for testing often originate from the same community and so their statuses may exhibit positive correlation. Dorfman's protocol screens a population of n specimens for a binary trait by partitioning it into nonoverlapping groups, testing these, and only individually retesting the specimens of each positive group. The partition is chosen to minimize the expected number of tests under a probabilistic model of specimen statuses. We relax the typical assumption that these are independent and indentically distributed and instead model them as exchangeable random variables. In this case, their joint distribution is symmetric in the sense that it is invariant under permutations. We give a characterization of such distributions in terms of a function q where q(h) is the marginal probability that any group of size h tests negative. We use this interpretable representation to show that the set partitioning problem arising in Dorfman's protocol can be reduced to an integer partitioning problem and efficiently solved. We apply these tools to an empirical dataset from the COVID-19 pandemic. The methodology helps explain the unexpectedly high empirical efficiency reported by the original investigators.Comment: 20 pages w/o references, 2 figure