Refining Contract Management: Essays on Relational Contracting, Transaction Costs, and Text Analysis

This dissertation refines defense contracting by addressing aspects of managing contractual relationships. While the setting and data relate to defense contracts, the lessons can be expanded to nonprofit contracting beyond defense and even to contract management in general. First it presents a game theoretic model of a relational contract between a for-profit supplier and a non-profit buyer and explores how the model could be used to promote stability, manage costs, enhance cooperation, and encourage long-term capacity. The dissertation then explores governance alignment using transaction cost economics (TCE) and Department of the Air Force contracting data. One analysis uses data from the Federal Procurement Database System (FPDS) to demonstrate the effectiveness of distilling transaction cost characteristics from a comprehensive, readily available data source to assess appropriate contract governance. A second TCE study uses text analysis techniques including word embedding and the GloVe algorithm to build custom data dictionaries to evaluate contract requirements documents for transaction cost characteristics. These analyses can be used to guide decision-makers in selecting optimal contract governance approaches

Normal families of functions and groups of pseudoconformal diffeomorphisms of quaternion and octonion variables

This paper is devoted to the specific class of pseudoconformal mappings of quaternion and octonion variables. Normal families of functions are defined and investigated. Four criteria of a family being normal are proven. Then groups of pseudoconformal diffeomorphisms of quaternion and octonion manifolds are investigated. It is proven, that they are finite dimensional Lie groups for compact manifolds. Their examples are given. Many charactersitic features are found in comparison with commutative geometry over $\bf R$ or $\bf C$.Comment: 55 pages, 53 reference

Domino effects related to explosions in the framework of land use planning

The present study analyses the possible escalation due to the damage of industrial equipment containing hazardous materials loaded by pressure waves produced either by an accidental source as a Vapour Cloud Explosion, or by a voluntary external attack such as the explosion of a TNT charge located nearby the industrial facility. The results obtained evidence the similarities and the differences for the two explosion sources in terms of structural damage, loss of containment and of expected impacts on the population. In particular, a specific vulnerability assessment was carried out defining a case-study in order to evidence the different potential impact of domino effect triggered by internal process causes respect to escalation scenarios caused by external acts of interference. © 2013, AIDIC Servizi S.r.l

Lumped model for the assessment of the thermal and mechanical response of LNG tanks exposed to fire

Fires may impact on liquefied natural gas (LNG) process and storage units causing severe damages and potential accident escalation. In the present work, a lumped model able to predict the thermal response of LNG tanks exposed to fire is presented. The model is based on a thermal nodes approach, solving heat and material balances on the equipment exposed to fire, contemplating boiling regime phenomena, heat-up and pressure build up. The model allowed obtaining key indications for the evaluation of the vessel resistance during fire exposure. The model was applied to reproduce the accident scenario occurred at Tivissa (Spain) in 2002 and applied to an industrial case study

Thyroid Hormone, Thyroid Hormone Metabolites and Mast Cells: A Less Explored Issue.

Mast cells are primary players in immune and inflammatory diseases. In the brain, mast cells are located at the brain side of the blood brain barrier (BBB) exerting a crucial role in protecting the brain from xenobiotic invasion. Furthermore, recent advances in neuroscience indicate mast cells may play an important role in glial cell-neuron communication through the release of mediators, including histamine. Interestingly, brain mast cells contain not only 50% of the brain histamine but also hormones, proteases and lipids or amine mediators; and cell degranulation may be triggered by different stimuli activating membrane bound receptors including the four types of histaminergic receptors. Among hormones, mast cells can store thyroid hormone (T3) and express membrane-bound thyroid stimulating hormone receptors (TSHRs), thus suggesting from one side that thyroid function may affect mast cells function, from the other that mast cell degranulation may impact on thyroid function. In this respect, the research on hormones in mast cells is scarce. Recent pharmacological evidence indicates the existence of a non-genomic portion of the thyroid secretion including thyroid hormone metabolites. Among which the 3,5 diiodothyronine (3,5-T2), 3-iodothyroanamine (T1AM) and 3-iodothyroacetic acid (TA1) are the most studied. All these compounds are endogenously occurring and found to be increased in inflammatory-based diseases involving mast cells. T1AM and TA1 induce, as T3, neuroprotective effects and itch but also hyperalgesia in rodents with a mechanism largely unknown but mediated by the release of histamine. Due to the rapid onset of their effectiveness they may trigger histamine release from a cell where it is "ready-to-be released," i.e., mast cells. Following a very thin path which passes through old experimental and clinical evidence, at the light of novel acquisitions on endogenous T3 metabolites, we aim to stimulate the attention on the possibility that mast cell histamine may be the connector of a novel (neuro) endocrine pathway linking the thyroid with mast cells

Efficacy of topical imiquimod 3.75% in the treatment of actinic keratosis of the scalp in immunosuppressed patients: our case series

AbstractBackground: Actinic keratoses (AK) represent common cutaneous lesions, appearing in 'Field cancerization areas' and potentially evolving toward invasive neoplasm. Immunosuppressed patients ..