5,914 research outputs found

    F as in Fat: How Obesity Threatens America’s Future 2012

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    https://www.rwjf.org/content/dam/farm/reports/reports/2012/rwjf40131

    Exactly solvable scale-free network model

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    We study a deterministic scale-free network recently proposed by Barab\'{a}si, Ravasz and Vicsek. We find that there are two types of nodes: the hub and rim nodes, which form a bipartite structure of the network. We first derive the exact numbers P(k)P(k) of nodes with degree kk for the hub and rim nodes in each generation of the network, respectively. Using this, we obtain the exact exponents of the distribution function P(k)P(k) of nodes with kk degree in the asymptotic limit of kk \to \infty. We show that the degree distribution for the hub nodes exhibits the scale-free nature, P(k)kγP(k) \propto k^{-\gamma} with γ=ln3/ln2=1.584962\gamma = \ln3/\ln2 = 1.584962, while the degree distribution for the rim nodes is given by P(k)eγkP(k) \propto e^{-\gamma'k} with γ=ln(3/2)=0.405465\gamma' = \ln(3/2) = 0.405465. Second, we numerically as well as analytically calculate the spectra of the adjacency matrix AA for representing topology of the network. We also analytically obtain the exact number of degeneracy at each eigenvalue in the network. The density of states (i.e., the distribution function of eigenvalues) exhibits the fractal nature with respect to the degeneracy. Third, we study the mathematical structure of the determinant of the eigenequation for the adjacency matrix. Fourth, we study hidden symmetry, zero modes and its index theorem in the deterministic scale-free network. Finally, we study the nature of the maximum eigenvalue in the spectrum of the deterministic scale-free network. We will prove several theorems for it, using some mathematical theorems. Thus, we show that most of all important quantities in the network theory can be analytically obtained in the deterministic scale-free network model of Barab\'{a}si, Ravasz and Vicsek. Therefore, we may call this network model the exactly solvable scale-free network.Comment: 18 pages, 5 figure

    An R- and I-Band Photometric Variability Survey of the Cygnus OB2 Association

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    We present a catalog of photometrically variable stars discovered within two 21'.3 X 21'.3 fields centered on the Cygnus OB2 association. There have hitherto been no deep optical variability studies of Cyg OB2 despite it being replete with early-type massive stars, perhaps due to the high and variable extinction (up to A_V ~ 20) that permeates much of the region. Here we provide results of the first variability study with this combination of spatial coverage (~ 0.5 deg) and photometric depth (R ~ 21 mag). We find 121 stars to be variable in both R- and I-band, 116 of them newly discovered. Of the 121 variables, we identify 27 eclipsing binaries (EBs) and eclipsing binary candidates, 20 potential Herbig Ae/Be stars, and 52 pulsating variables. Confirming both the status and the cluster membership of the Herbig Ae/Be stars would address the uncertainty regarding the age and star formation history of Cyg OB2. We match our catalog to known variables and binaries in the region, 2MASS near-IR (NIR) data, and Chandra X-ray observations to find counterparts to new variables in other wavelengths.Comment: 34 pages, 12 figures, submitted to Ap

    Design Principles for Energy-Efficient Legged Locomotion and Implementation on the MIT Cheetah Robot

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    This paper presents the design principles for highly efficient legged robots, the implementation of the principles in the design of the MIT Cheetah, and the analysis of the high-speed trotting experimental results. The design principles were derived by analyzing three major energy-loss mechanisms in locomotion: heat losses from the actuators, friction losses in transmission, and the interaction losses caused by the interface between the system and the environment. Four design principles that minimize these losses are discussed: employment of high torque-density motors, energy regenerative electronic system, low loss transmission, and a low leg inertia. These principles were implemented in the design of the MIT Cheetah; the major design features are large gap diameter motors, regenerative electric motor drivers, single-stage low gear transmission, dual coaxial motors with composite legs, and the differential actuated spine. The experimental results of fast trotting are presented; the 33-kg robot runs at 22 km/h (6 m/s). The total power consumption from the battery pack was 973 W and resulted in a total cost of transport of 0.5, which rivals running animals' at the same scale. 76% of the total energy consumption is attributed to heat loss from the motor, and the remaining 24% is used in mechanical work, which is dissipated as interaction loss as well as friction losses at the joint and transmission.United States. Defense Advanced Research Projects Agency (M3 Program

    A Difference Version of Nori's Theorem

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    We consider (Frobenius) difference equations over (F_q(s,t), phi) where phi fixes t and acts on F_q(s) as the Frobenius endomorphism. We prove that every semisimple, simply-connected linear algebraic group G defined over F_q can be realized as a difference Galois group over F_{q^i}(s,t) for some i in N. The proof uses upper and lower bounds on the Galois group scheme of a Frobenius difference equation that are developed in this paper. The result can be seen as a difference analogue of Nori's Theorem which states that G(F_q) occurs as (finite) Galois group over F_q(s).Comment: 29 page

    On the behaviour of Brauer pp-dimensions under finitely-generated field extensions

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    The present paper shows that if qPq \in \mathbb P or q=0q = 0, where P\mathbb P is the set of prime numbers, then there exist characteristic qq fields Eq,k ⁣: kNE _{q,k}\colon \ k \in \mathbb N, of Brauer dimension Brd(Eq,k)=k(E _{q,k}) = k and infinite absolute Brauer pp-dimensions abrdp(Eq,k)_{p}(E _{q,k}), for all pPp \in \mathbb P not dividing q2qq ^{2} - q. This ensures that Brdp(Fq,k)=_{p}(F _{q,k}) = \infty , pq2qp \dagger q ^{2} - q, for every finitely-generated transcendental extension Fq,k/Eq,kF _{q,k}/E _{q,k}. We also prove that each sequence ap,bpa _{p}, b _{p}, pPp \in \mathbb P, satisfying the conditions a2=b2a _{2} = b _{2} and 0bpap0 \le b _{p} \le a _{p} \le \infty , equals the sequence abrdp(E),Brdp(E)_{p}(E), {\rm Brd}_{p}(E), pPp \in \mathbb P, for a field EE of characteristic zero.Comment: LaTeX, 14 pages: published in Journal of Algebra {\bf 428} (2015), 190-204; the abstract in the Metadata updated to fit the one of the pape

    Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing

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    Background Six Plasmodium species are known to naturally infect humans. Mixed species infections occur regularly but morphological discrimination by microscopy is difficult and multiplicity of infection (MOI) can only be evaluated by molecular methods. This study investigated the complexity of Plasmodium infections in patients treated for microscopically detected non- falciparum or mixed species malaria in Gabon. Methods Ultra-deep sequencing of nucleus (18S rRNA), mitochondrion, and apicoplast encoded genes was used to evaluate Plasmodium species diversity and MOI in 46 symptomatic Gabonese patients with microscopically diagnosed non-falciparum or mixed species malaria. Results Deep sequencing revealed a large complexity of coinfections in patients with uncomplicated malaria, both on species and genotype levels. Mixed infections involved up to four parasite species (Plasmodium falciparum, Plasmodium malariae, Plasmodium ovale curtisi, and P. ovale wallikeri). Multiple genotypes from each species were determined from the asexual 18S rRNA gene. 17 of 46 samples (37%) harboured multiple genotypes of at least one Plasmodium species. The number of genotypes per sample (MOI) was highest in P. malariae (n = 4), followed by P. ovale curtisi (n = 3), P. ovale wallikeri (n = 3), and P. falciparum (n = 2). The highest combined genotype complexity in samples that contained mixed-species infections was seven. Conclusions Ultra- deep sequencing showed an unexpected breadth of Plasmodium species and within species diversity in clinical samples. MOI of P. ovale curtisi, P. ovale wallikeri and P. malariae infections were higher than anticipated and contribute significantly to the burden of malaria in Gabon

    A Computational Algebra Approach to the Reverse Engineering of Gene Regulatory Networks

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    This paper proposes a new method to reverse engineer gene regulatory networks from experimental data. The modeling framework used is time-discrete deterministic dynamical systems, with a finite set of states for each of the variables. The simplest examples of such models are Boolean networks, in which variables have only two possible states. The use of a larger number of possible states allows a finer discretization of experimental data and more than one possible mode of action for the variables, depending on threshold values. Furthermore, with a suitable choice of state set, one can employ powerful tools from computational algebra, that underlie the reverse-engineering algorithm, avoiding costly enumeration strategies. To perform well, the algorithm requires wildtype together with perturbation time courses. This makes it suitable for small to meso-scale networks rather than networks on a genome-wide scale. The complexity of the algorithm is quadratic in the number of variables and cubic in the number of time points. The algorithm is validated on a recently published Boolean network model of segment polarity development in Drosophila melanogaster.Comment: 28 pages, 5 EPS figures, uses elsart.cl

    Recent Topics on Very High Energy Gamma-ray Astronomy

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    With the advent of imaging atmospheric Cherenkov telescopes in late 1980's, ground-based observation of TeV gamma-rays came into reality after struggling trials by pioneers for twenty years, and the number of gamma-ray sources detected at TeV energies has increased to be over seventy now. In this review, recent findings from ground-based very-high-energy gamma-ray observations are summarized (as of 2008 March), and up-to-date problems in this research field are presented.Comment: 6 pages, 4 figures, Proceedings of the International Workshop on Advances in Cosmic Ray Science, March 17-19, 2008, Waseda University, Tokyo, Japan; to be published in Journal of the Physical Society of Japan (supplement
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