Drug treatment of hypertension: focus on vascular health

Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart disease and renal failure. While many systems contribute to blood pressure (BP) elevation, the vascular system is particularly important because vascular dysfunction is a cause and consequence of hypertension. Hypertension is characterised by a vascular phenotype of endothelial dysfunction, arterial remodelling, vascular inflammation and increased stiffness. Antihypertensive drugs that influence vascular changes associated with high BP have greater efficacy for reducing cardiovascular risk than drugs that reduce BP, but have little or no effect on the adverse vascular phenotype. Angiotensin converting enzyme ACE inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) improve endothelial function and prevent vascular remodelling. Calcium channel blockers also improve endothelial function, although to a lesser extent than ACEIs and ARBs. Mineralocorticoid receptor blockers improve endothelial function and reduce arterial stiffness, and have recently become more established as antihypertensive drugs. Lifestyle factors are essential in preventing the adverse vascular changes associated with high BP and reducing associated cardiovascular risk. Clinicians and scientists should incorporate these factors into treatment decisions for patients with high BP, as well as in the development of new antihypertensive drugs that promote vascular health

Quantum critical behaviour of the plateau-insulator transition in the quantum Hall regime

High-field magnetotransport experiments provide an excellent tool to investigate the plateau-insulator phase transition in the integral quantum Hall effect. Here we review recent low-temperature high-field magnetotransport studies carried out on several InGaAs/InP heterostructures and an InGaAs/GaAs quantum well. We find that the longitudinal resistivity $\rho_{xx}$ near the critical filling factor $\nu_{c}$ ~ 0.5 follows the universal scaling law $\rho_{xx}(\nu, T) \propto exp[-\Delta \nu/(T/T_{0})^{\kappa}]$, where $\Delta \nu =\nu -\nu_{c}$. The critical exponent $\kappa$ equals $0.56 \pm 0.02$, which indicates that the plateau-insulator transition falls in a non-Fermi liquid universality class.Comment: 8 pages, accepted for publication in Proceedings of the Yamada Conference LX on Research in High Magnetic Fields (August 16-19, 2006, Sendai

Electron-Transport Properties of Na Nanowires under Applied Bias Voltages

We present first-principles calculations on electron transport through Na nanowires at finite bias voltages. The nanowire exhibits a nonlinear current-voltage characteristic and negative differential conductance. The latter is explained by the drastic suppression of the transmission peaks which is attributed to the electron transportability of the negatively biased plinth attached to the end of the nanowire. In addition, the finding that a voltage drop preferentially occurs on the negatively biased side of the nanowire is discussed in relation to the electronic structure and conduction.Comment: 4 pages, 6 figure

Binary neutron star mergers: a jet engine for short gamma-ray bursts

We perform magnetohydrodynamic simulations in full general relativity (GRMHD) of quasi-circular, equal-mass, binary neutron stars that undergo merger. The initial stars are irrotational, $n=1$ polytropes and are magnetized. We explore two types of magnetic-field geometries: one where each star is endowed with a dipole magnetic field extending from the interior into the exterior, as in a pulsar, and the other where the dipole field is initially confined to the interior. In both cases the adopted magnetic fields are initially dynamically unimportant. The merger outcome is a hypermassive neutron star that undergoes delayed collapse to a black hole (spin parameter $a/M_{\rm BH} \sim 0.74$) immersed in a magnetized accretion disk. About $4000M \sim 60(M_{\rm NS}/1.625M_\odot)$ ms following merger, the region above the black hole poles becomes strongly magnetized, and a collimated, mildly relativistic outflow --- an incipient jet --- is launched. The lifetime of the accretion disk, which likely equals the lifetime of the jet, is $\Delta t \sim 0.1 (M_{\rm NS}/1.625M_\odot)$ s. In contrast to black hole--neutron star mergers, we find that incipient jets are launched even when the initial magnetic field is confined to the interior of the stars.Comment: 6 pages, 3 figures, 1 table, matches published versio

Single-particle and Interaction Effects on the Cohesion and Transport and Magnetic Properties of Metal Nanowires at Finite Voltages

The single-particle and interaction effects on the cohesion, electronic transport, and some magnetic properties of metallic nanocylinders have been studied at finite voltages by using a generalized mean-field electron model. The electron-electron interactions are treated in the self-consistent Hartree approximation. Our results show the single-particle effect is dominant in the cohesive force, while the nonzero magnetoconductance and magnetotension coefficients are attributed to the interaction effect. Both single-particle and interaction effects are important to the differential conductance and magnetic susceptibility.Comment: 5 pages, 6 figure