Embolization in an adrenocortical carcinoma as palliative therapy

Background: With an annual incidence of 0.2% of new cases per 100,000 inhabitants, adrenocortical carcinoma is rare. In advanced tumor only palliative treatment modalities are practicable. Because of scarcity of the tumor, standard treatment has not been defined. The decision on therapy frequently depends on the individual situation. Tumor embolization and chemotherapy are amongst the possible options. Patient and Methods: We report on a case of a 32-year-old female patient with a large-volume hormonally active adrenocortical carcinoma and hematogenous liver metastases. This carcinoma was confirmed histologically by means of liver biopsy. Owing to the large tumor extent and metastatic spreading and also in view of the poor general condition of the patient, curative surgical therapy was not possible. For this reason, a local approach was chosen primarily with transarterial tumor embolization at the capillary level. Systemic chemotherapy was given afterwards. Results: Improvement of the patient's general condition, especially the pronounced pain symptoms, could be achieved for a short time by the embolization: both, the patient's clinical condition and the laboratory test parameters improved. However, a rapid tumor progression occured under chemotherapy, which was started after embolization. Conclusion: In advanced adrenocortical carcinoma, tumor embolization can lead to a stabilization of the disease and improvement of the symptoms as appraised by palliative criteria in some patients

Towards a quantum field theory of primitive string fields

We denote generating functions of massless even higher spin fields "primitive string fields" (PSF's). In an introduction we present the necessary definitions and derive propagators and currents of these PDF's on flat space. Their off-shell cubic interaction can be derived after all off-shell cubic interactions of triplets of higher spin fields have become known [2],[3]. Then we discuss four-point functions of any quartet of PSF's. In subsequent sections we exploit the fact that higher spin field theories in $AdS_{d+1}$ are determined by AdS/CFT correspondence from universality classes of critical systems in $d$ dimensional flat spaces. The O(N) invariant sectors of the O(N) vector models for $1\leq N \leq \infty$ play for us the role of "standard models", for varying $N$, they contain e.g. the Ising model for N=1 and the spherical model for $N=\infty$. A formula for the masses squared that break gauge symmetry for these O(N) classes is presented for d = 3. For the PSF on $AdS$ space it is shown that it can be derived by lifting the PSF on flat space by a simple kernel which contains the sum over all spins. Finally we use an algorithm to derive all symmetric tensor higher spin fields. They arise from monomials of scalar fields by derivation and selection of conformal (quasiprimary) fields. Typically one monomial produces a multiplet of spin $s$ conformal higher spin fields for all $s \geq 4$, they are distinguished by their anomalous dimensions (in $CFT_3$) or by their mass (in $AdS_4$). We sum over these multiplets and the spins to obtain "string type fields", one for each such monomial.Comment: 16 pages,Late

Alternative approach to computing transport coefficients: application to conductivity and Hall coefficient of hydrogenated amorphous silicon

We introduce a theoretical framework for computing transport coefficients for complex materials. As a first example, we resolve long-standing inconsistencies between experiment and theory pertaining to the conductivity and Hall mobility for amorphous silicon and show that the Hall sign anomaly is a consequence of localized states. Next, we compute the AC conductivity of amorphous polyanaline. The formalism is applicable to complex materials involving defects and band-tail states originating from static topological disorder and extended states. The method may be readily integrated with current \textit{ab initio} methods.Comment: 4 pages, 2 figures, submitted to Phys. Rev. Let

Polaron cross-overs and d-wave superconductivity in Hubbard-Holstein model

We present a theoretical study of superconductivity of polarons in the Hubbard-Holstein model. A residual kinematic interaction proportional to the square of the polaron hopping energy between polarons and phonons provides a pairing field for the polarons. We find that superconducting instability in the d-wave channel is possible with small transition temperatures which is maximum in the large to small polaron cross-over region. An s-wave instability is found to be not possible when the effective on-site interaction between polarons is repulsive

Theory of Insulator Metal Transition and Colossal Magnetoresistance in Doped Manganites

The persistent proximity of insulating and metallic phases, a puzzling characterestic of manganites, is argued to arise from the self organization of the twofold degenerate e_g orbitals of Mn into localized Jahn-Teller(JT) polaronic levels and broad band states due to the large electron - JT phonon coupling present in them. We describe a new two band model with strong correlations and a dynamical mean-field theory calculation of equilibrium and transport properties. These explain the insulator metal transition and colossal magnetoresistance quantitatively, as well as other consequences of two state coexistence

The magnetic environment in the central region of nearby galaxies

The central regions of galaxies harbor some of the most extreme physical phenomena, including dense stellar clusters, non-circular motions of molecular clouds and strong and pervasive magnetic field structures. In particular, radio observations have shown that the central few hundred parsecs of our Galaxy has a striking magnetic field configuration. It is not yet clear whether these magnetic structures are unique to our Milky Way or a common feature of all similar galaxies. Therefore, we report on (a) a new radio polarimetric survey of the central 200 pc of the Galaxy to better characterize the magnetic field structure and (b) a search for large-scale and organized magnetized structure in the nuclear regions of nearby galaxies using data from the Very Large Array (VLA) archive. The high angular resolution of the VLA allows us to study the central 1 kpc of the nearest galaxies to search for magnetized nuclear features similar to what is detected in our own Galactic center. Such magnetic features play a important role in the nuclear regions of galaxies in terms of gas transport and the physical conditions of the interstellar medium in this unusual region of galaxies.Comment: 8 pages; Proceedings for "The Universe under the Microscope" (AHAR 2008), held in Bad Honnef (Germany) in April 2008, to be published in Journal of Physics: Conference Series by Institute of Physics Publishing, R. Schoedel, A. Eckart, S. Pfalzner, and E. Ros (eds.

Discovery of a Non-Thermal Galactic Center Filament (G358.85+0.47) Parallel to the Galactic Plane

We report the discovery of a new non-thermal filament, G358.85+0.47, the ``Pelican'', located ~225 pc in projection from SgrA, and oriented parallel to the Galactic plane. VLA continuum observations at 20 cm reveal that this 7' (17.5 pc) structure bends at its northern extension and is comprised of parallel strands, most apparent at its ends. Observations at 6 and 3.6 cm reveal that the Pelican is a synchrotron-emitting source and is strongly linearly polarized over much of its extent. The spectral index of the filament changes from alpha(20/6)=-0.8 to alpha(6/3.6)=-1.5. The rotation measures exhibit a smooth gradient, with values ranging from -1000 rad/m2 to +500 rad/m2. The intrinsic magnetic field is well-aligned along the length of the filament. Based on these properties, we classify the Pelican as one of the non-thermal filaments unique to the Galactic center. Since these filaments (most of which are oriented perpendicular to the Galactic plane) are believed to trace the overall magnetic field in the inner Galaxy, the Pelican is the first detection of a component of this field parallel to the plane. The Pelican may thus mark a transition region of the magnetic field orientation in the inner kiloparsec of the Galaxy.Comment: 6 pages, 4 figures, to appear in ApJ Letters; Figs. 2 & 3 are color .ps files and best viewed in colo

Creation of ventricular septal defects on the beating heart in a new pig model

Background/ Aims: So far, surgical and interventional therapies for muscular ventricular septal defects ( mVSDs) beyond the moderator band have had their limitations. Thus, alternative therapeutic strategies should be developed. We present a new animal model for the evaluation of such strategies. Methods: In a pig model ( n = 9), anterolateral thoracotomy was performed for exposure of the left ventricle. mVSDs were created under two- and three- dimensional echocardiography with a 7.5- mm sharp punch instrument, which was forwarded via a left ventricular puncture without extracorporeal circulation. Results: Creation of mVSDs was successful in all animals ( n = 9) confirmed by echocardiography, hemodynamic measurements and autopsy. The defects were located in the midmuscular ( n = 4), apical ( n = 1), inlet ( n = 2) and anterior part ( n = 2) of the muscular septum. All animals were hemodynamically stable for further procedures. The diameter and shunt volume of the mVSDs were 4.8 - 7.3 mm ( mean: 5.9 mm) and 12.9 - 41.3% ( mean: 22.1%), respectively. Autopsy confirmed in all animals the creation of a substantial defect. Conclusion: The described new technique for creation of an mVSD on the beating heart in a pig model is suitable for the evaluation of new therapeutic strategies for mVSD closure. Copyright (C) 2008 S. Karger AG, Basel

Interaction of strongly correlated electrons and acoustical phonons

We investigate the interaction of correlated electrons with acoustical phonons using the extended Hubbard-Holstein model in which both, the electron-phonon interaction and the on-site Coulomb repulsion are considered to be strong. The Lang-Firsov canonical transformation allows to obtain mobile polarons for which a new diagram technique and generalized Wick's theorem is used. This allows to handle the Coulomb repulsion between the electrons emerged into a sea of phonon fields (\textit{phonon clouds}). The physics of emission and absorption of the collective phonon-field mode by the polarons is discussed in detail. Moreover, we have investigated the different behavior of optical and acoustical phonon clouds when propagating through the lattice. In the strong-coupling limit of the electron-phonon interaction, and in the normal as well as in the superconducting phase, chronological thermodynamical averages of products of acoustical phonon-cloud operators can be expressed by one-cloud operator averages. While the normal one-cloud propagator has the form of a Lorentzian, the anomalous one is of Gaussian form and considerably smaller. Therefore, the anomalous electron Green's functions can be considered to be more important than corresponding polarons functions, i.e., pairing of electrons without phonon-clouds is easier to achieve than pairing of polarons with such clouds.Comment: : 28 pages, 9 figures, revtex4. Invited paper for a special issue of Low Temperature Physics dedicated to the 20th anniversary of HTS

Tidal deformability of neutron stars with realistic equations of state and their gravitational wave signatures in binary inspiral

The early part of the gravitational wave signal of binary neutron star inspirals can potentially yield robust information on the nuclear equation of state. The influence of a star's internal structure on the waveform is characterized by a single parameter: the tidal deformability lambda, which measures the star's quadrupole deformation in response to the companion's perturbing tidal field. We calculate lambda for a wide range of equations of state and find that the value of lambda spans an order of magnitude for the range of equation of state models considered. An analysis of the feasibility of discriminating between neutron star equations of state with gravitational wave observations of the early part of the inspiral reveals that the measurement error in lambda increases steeply with the total mass of the binary. Comparing the errors with the expected range of lambda, we find that Advanced LIGO observations of binaries at a distance of 100 Mpc will probe only unusually stiff equations of state, while the proposed Einstein Telescope is likely to see a clean tidal signature.Comment: 12 pages, submitted to PR