Massive Gravitino Propagator in Maximally Symmetric Spaces and Fermions in dS/CFT

We extend the method of calculation of propagators in maximally symmetric spaces (Minkowski, dS, AdS and their Euclidean versions) in terms of intrinsic geometric objects to the case of massive spin 3/2 field. We obtain the propagator for arbitrary space-time dimension and mass in terms of Heun's function, which is a generalization of the hypergeometric function appearing in the case of other spins. As an application of this result we calculate the conformal dimension of the dual operator in the recently proposed dS/CFT correspondence both for spin 3/2 and for spin 1/2. We find that, in agreement with the expectation from analytic continuation from AdS, the conformal dimension of the dual operator is {\it always} complex (i.e. it is complex for every space-time dimension and value of the mass parameter). We comment on the implications of this result for fermions in dS/CFT.Comment: 20 pages, references added, v3: typos fixe

Gravitational Higgs Mechanism

We discuss the gravitational Higgs mechanism in domain wall background solutions that arise in the theory of 5-dimensional Einstein-Hilbert gravity coupled to a scalar field with a non-trivial potential. The scalar fluctuations in such backgrounds can be completely gauged away, and so can be the graviphoton fluctuations. On the other hand, we show that the graviscalar fluctuations do not have normalizable modes. As to the 4-dimensional graviton fluctuations, in the case where the volume of the transverse dimension is finite the massive modes are plane-wave normalizable, while the zero mode is quadratically normalizable. We then discuss the coupling of domain wall gravity to localized 4-dimensional matter. In particular, we point out that this coupling is consistent only if the matter is conformal. This is different from the Randall-Sundrum case as there is a discontinuity in the delta-function-like limit of such a smooth domain wall - the latter breaks diffeomorphisms only spontaneously, while the Randall-Sundrum brane breaks diffeomorphisms explicitly. Finally, at the quantum level both the domain wall as well as the Randall-Sundrum setups suffer from inconsistencies in the coupling between gravity and localized matter, as well as the fact that gravity is generically expected to be delocalized in such backgrounds due to higher curvature terms.Comment: 16 pages, revtex; a minor correctio

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.

To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths. We found repeat length-dependent transcriptional signatures to be prominent in the striatum, less so in cortex, and minimal in the liver. Coexpression network analyses revealed 13 striatal and 5 cortical modules that correlated highly with CAG length and age, and that were preserved in HD models and sometimes in patients. Top striatal modules implicated mHtt CAG length and age in graded impairment in the expression of identity genes for striatal medium spiny neurons and in dysregulation of cyclic AMP signaling, cell death and protocadherin genes. We used proteomics to confirm 790 genes and 5 striatal modules with CAG length-dependent dysregulation at the protein level, and validated 22 striatal module genes as modifiers of mHtt toxicities in vivo

Warped Spectroscopy: Localization of Frozen Bulk Modes

We study the 10D equation of motion of dilaton-axion fluctuations in type IIB string compactifications with three-form flux, taking warping into account. Using simplified models with physics comparable to actual compactifications, we argue that the lightest mode localizes in long warped throats and takes a mass of order the warped string scale. Also, Gukov-Vafa-Witten superpotential is valid for the lightest mass mode; however, the mass is similar to the Kaluza-Klein scale, so the dilaton-axion should be integrated out of the effective theory in this long throat regime (leaving a constant superpotential). On the other hand, there is a large hierarchy between flux-induced and KK mass scales for moderate or weak warping. This hierarchy agrees with arguments given for trivial warping. Along the way, we also estimate the effect of the other 10D supergravity equations of motion on the dilaton-axion fluctuation, since these equations act as constraints. We argue that they give negligible corrections to the simplest approximation.Comment: 24pp + appendices, 6 figs, JHEP3 class; v2. corrected reference; v3. added clarifications; v4. corrected typo

Reverse Engineering Gene Networks with ANN: Variability in Network Inference Algorithms

Motivation :Reconstructing the topology of a gene regulatory network is one of the key tasks in systems biology. Despite of the wide variety of proposed methods, very little work has been dedicated to the assessment of their stability properties. Here we present a methodical comparison of the performance of a novel method (RegnANN) for gene network inference based on multilayer perceptrons with three reference algorithms (ARACNE, CLR, KELLER), focussing our analysis on the prediction variability induced by both the network intrinsic structure and the available data. Results: The extensive evaluation on both synthetic data and a selection of gene modules of "Escherichia coli" indicates that all the algorithms suffer of instability and variability issues with regards to the reconstruction of the topology of the network. This instability makes objectively very hard the task of establishing which method performs best. Nevertheless, RegnANN shows MCC scores that compare very favorably with all the other inference methods tested. Availability: The software for the RegnANN inference algorithm is distributed under GPL3 and it is available at the corresponding author home page (http://mpba.fbk.eu/grimaldi/regnann-supmat

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.

Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple coordinated blood leukocyte gene coexpression modules and the multivariate functional neuroimaging (fMRI) response to speech. Gene coexpression modules associated with the multivariate fMRI response to speech were different for all pairwise comparisons between typically developing toddlers and toddlers with ASD and poor versus good early language outcome. Associated coexpression modules were enriched in genes that are broadly expressed in the brain and many other tissues. These coexpression modules were also enriched in ASD-associated, prenatal, human-specific, and language-relevant genes. This work highlights distinctive neurobiology in ASD subtypes with different early language outcomes that is present well before such outcomes are known. Associations between neuroimaging measures and gene expression levels in blood leukocytes may offer a unique in vivo window into identifying brain-relevant molecular mechanisms in ASD

Energy Transfer between Throats from a 10d Perspective

Strongly warped regions, also known as throats, are a common feature of the type IIB string theory landscape. If one of the throats is heated during cosmological evolution, the energy is subsequently transferred to other throats or to massless fields in the unwarped bulk of the Calabi-Yau orientifold. This energy transfer proceeds either by Hawking radiation from the black hole horizon in the heated throat or, at later times, by the decay of throat-localized Kaluza-Klein states. In both cases, we calculate in a 10d setup the energy transfer rate (respectively decay rate) as a function of the AdS scales of the throats and of their relative distance. Compared to existing results based on 5d models, we find a significant suppression of the energy transfer rates if the size of the embedding Calabi-Yau orientifold is much larger than the AdS radii of the throats. This effect can be partially compensated by a small distance between the throats. These results are relevant, e.g., for the analysis of reheating after brane inflation. Our calculation employs the dual gauge theory picture in which each throat is described by a strongly coupled 4d gauge theory, the degrees of freedom of which are localized at a certain position in the compact space.Comment: 25 pages; a comment adde

Cosmic Super-Strings and Kaluza-Klein Modes

Cosmic super-strings interact generically with a tower of relatively light and/or strongly coupled Kaluza-Klein (KK) modes associated with the geometry of the internal space. In this paper, we study the production of spin-2 KK particles by cusps on loops of cosmic F- and D-strings. We consider cosmic super-strings localized either at the bottom of a warped throat or in a flat internal space with large volume. The total energy emitted by cusps in KK modes is comparable in both cases, although the number of produced KK modes may differ significantly. We then show that KK emission is constrained by the photo-dissociation of light elements and by observations of the diffuse gamma ray background. We show that this rules out regions of the parameter space of cosmic super-strings that are complementary to the regions that can be probed by current and upcoming gravitational wave experiments. KK modes are also expected to play an important role in the friction-dominated epoch of cosmic super-string evolution.Comment: 35pp, 5 figs, v2: minor modifications and Refs. added, matches published versio

Warped Supersymmetry Breaking

We address the size of supersymmetry-breaking effects within higher-dimensional settings where the observable sector resides deep within a strongly warped region, with supersymmetry breaking not necessarily localized in that region. Our particular interest is in how the supersymmetry-breaking scale seen by the observable sector depends on this warping. We obtain this dependence in two ways: by computing within the microscopic (string) theory supersymmetry-breaking masses in supermultiplets; and by investigating how warping gets encoded into masses within the low-energy 4D effective theory. We find that the lightest gravitino mode can have mass much less than the straightforward estimate from the mass shift of the unwarped zero mode. This lightest Kaluza-Klein excitation plays the role of the supersymmetric partner of the graviton and has a warped mass m_{3/2} proportional to e^A, with e^A the warp factor, and controls the size of the soft SUSY breaking terms. We formulate the conditions required for the existence of a description in terms of a 4D SUGRA formulation, or in terms of 4D SUGRA together with soft-breaking terms, and describe in particular situations where neither exist for some non-supersymmetric compactifications. We suggest that some effects of warping are captured by a linear $A$ dependence in the Kahler potential. We outline some implications of our results for the KKLT scenario of moduli stabilization with broken SUSY.Comment: 34 pages, 1 figure. v2 Further discussion of dual interpretation and gravitino mas

Lectures on Cosmic Inflation and its Potential Stringy Realizations

These notes present a brief introduction to Hot Big Bang cosmology and Cosmic Inflation, together with a selection of some recent attempts to embed inflation into string theory. They provide a partial description of lectures presented in courses at Dubrovnik in August 2006, at CERN in January 2007 and at Cargese in August 2007. They are aimed at graduate students with a working knowledge of quantum field theory, but who are unfamiliar with the details of cosmology or of string theory.Comment: 68 pages, lectures given at Dubrovnik, Aug 2006; CERN, January 2007; and Cargese, Aug 200