Universality in D-brane Inflation

We study the six-field dynamics of D3-brane inflation for a general scalar potential on the conifold, finding simple, universal behavior. We numerically evolve the equations of motion for an ensemble of more than 7 \times 10^7 realizations, drawing the coefficients in the scalar potential from statistical distributions whose detailed properties have demonstrably small effects on our results. When prolonged inflation occurs, it has a characteristic form: the D3-brane initially moves rapidly in the angular directions, spirals down to an inflection point in the potential, and settles into single-field inflation. The probability of N_{e} e-folds of inflation is a power law, P(N_{e}) \propto N_{e}^{-3}, and we derive the same exponent from a simple analytical model. The success of inflation is relatively insensitive to the initial conditions: we find attractor behavior in the angular directions, and the D3-brane can begin far above the inflection point without overshooting. In favorable regions of the parameter space, models yielding 60 e-folds of expansion arise approximately once in 10^3 trials. Realizations that are effectively single-field and give rise to a primordial spectrum of fluctuations consistent with WMAP, for which at least 120 e-folds are required, arise approximately once in 10^5 trials. The emergence of robust predictions from a six-field potential with hundreds of terms invites an analytic approach to multifield inflation.Comment: 28 pages, 9 figure

Kahler moduli double inflation

We show that double inflation is naturally realized in K\"ahler moduli inflation, which is caused by moduli associated with string compactification. We find that there is a small coupling between the two inflatons which leads to amplification of perturbations through parametric resonance in the intermediate stage of double inflation. This results in the appearance of a peak in the power spectrum of the primordial curvature perturbation. We numerically calculate the power spectrum and show that the power spectrum can have a peak on observationally interesing scales. We also compute the TT-spectrum of CMB based on the power spectrum with a peak and see that it better fits WMAP 7-years data.Comment: 21 pages, 8 figure

Semiclassical relations and IR effects in de Sitter and slow-roll space-times

We calculate IR divergent graviton one-loop corrections to scalar correlators in de Sitter space, and show that the leading IR contribution may be reproduced via simple semiclassical consistency relations. One can likewise use such semiclassical relations to calculate leading IR corrections to correlators in slow-roll inflation. The regulated corrections shift the tensor/scalar ratio and consistency relation of single field inflation, and non-gaussianity parameters averaged over very large distances. For inflation of sufficient duration, for example arising from a chaotic inflationary scenario, these corrections become of order unity. First-order corrections of this size indicate a breakdown of the perturbative expansion, and suggest the need for a non-perturbative description of the corresponding regime. This is analogous to a situation argued to arise in black hole evolution, and to interfere with a sharp perturbative calculation of "missing information" in Hawking radiation.Comment: 32 pages, 2 figures; v2: running of spectral index included and other minor changes; v3: minor changes to agree with published versio

Pairing in two-dimensional boson-fermion mixtures

The possibilities of pairing in two-dimensional boson-fermion mixtures are carefully analyzed. It is shown that the boson-induced attraction between two identical fermions dominates the p-wave pairing at low density. For a given fermion density, the pairing gap becomes maximal at a certain optimal boson concentration. The conditions for observing pairing in current experiments are discussedComment: 10 pages, 5 figs, revtex

Large slow-roll corrections to the bispectrum of noncanonical inflation

Nongaussian statistics are a powerful discriminant between inflationary models, particularly those with noncanonical kinetic terms. Focusing on theories where the Lagrangian is an arbitrary Lorentz-invariant function of a scalar field and its first derivatives, we review and extend the calculation of the observable three-point function. We compute the "next-order" slow-roll corrections to the bispectrum in closed form, and obtain quantitative estimates of their magnitude in DBI and power-law k-inflation. In the DBI case our results enable us to estimate corrections from the shape of the potential and the warp factor: these can be of order several tens of percent. We track the possible sources of large logarithms which can spoil ordinary perturbation theory, and use them to obtain a general formula for the scale dependence of the bispectrum. Our result satisfies the next-order version of Maldacena's consistency condition and an equivalent consistency condition for the scale dependence. We identify a new bispectrum shape available at next-order, which is similar to a shape encountered in Galileon models. If fNL is sufficiently large this shape may be independently detectable.Comment: v1: 37 pages, plus tables, figures and appendices. v2: supersedes version published in JCAP; some clarifications and more detailed comparison with earlier literature. All results unchanged. v3:improvements to some plots; text unchange

Features of heavy physics in the CMB power spectrum

The computation of the primordial power spectrum in multi-field inflation models requires us to correctly account for all relevant interactions between adiabatic and non-adiabatic modes around and after horizon crossing. One specific complication arises from derivative interactions induced by the curvilinear trajectory of the inflaton in a multi-dimensional field space. In this work we compute the power spectrum in general multi-field models and show that certain inflaton trajectories may lead to observationally significant imprints of `heavy' physics in the primordial power spectrum if the inflaton trajectory turns, that is, traverses a bend, sufficiently fast (without interrupting slow roll), even in cases where the normal modes have masses approaching the cutoff of our theory. We emphasise that turning is defined with respect to the geodesics of the sigma model metric, irrespective of whether this is canonical or non-trivial. The imprints generically take the form of damped superimposed oscillations on the power spectrum. In the particular case of two-field models, if one of the fields is sufficiently massive compared to the scale of inflation, we are able to compute an effective low energy theory for the adiabatic mode encapsulating certain relevant operators of the full multi-field dynamics. As expected, a particular characteristic of this effective theory is a modified speed of sound for the adiabatic mode which is a functional of the background inflaton trajectory and the turns traversed during inflation. Hence in addition, we expect non-Gaussian signatures directly related to the features imprinted in the power spectrum.Comment: 41 pages, 6 figures, references updated, minor modifications. Version to appear in JCAP. v4: Equations (4.28) and (4.30) and Figures 5 and 6 correcte

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Introduction of Routine Zinc Therapy for Children with Diarrhoea: Evaluation of Safety

On 8 May 2004, the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) recommended routine administration of zinc in the management of children, aged less than five years, with acute diarrhoea. In making the recommendation, WHO and UNICEF also suggested careful monitoring for adverse events associated with routine administration of zinc, particularly unusual or excess vomiting. The study assessed, in a phase IV trial, i.e. post-marketing surveillance of zinc, the occurrence of adverse events during the first hour after the administration of the first dose of zinc in children with acute or persistent diarrhoea. The study was conducted at the Dhaka Hospital of ICDDR,B and at an outpatient clinic operated by a local health NGO—Progoti Samaj Kallyan Protisthan (PSKP), Dhaka, Bangladesh. Eligible children, aged 3-59 months, were treated with 20 mg of zinc sulphate provided in a dispersible tablet formulation. The children were observed for 60 minutes following the initial treatment with zinc for adverse events, with particular attention given to vomiting or regurgitation. During the one-year observation period, 42,440 children (male 57% and female 43%) received zinc, and 20,246 (47.8%) of them were observed. Regurgitation and/or vomiting occurred in 4,392 (21.8%) of the children; 90.8% of these children had vomiting only once, 8.7% twice, and 0.5% more than twice. No children revisited the hospital for recurrent vomiting following their discharge. A significant proportion of infants and children may experience vomiting or regurgitation, usually once, following the administration of the first dose of zinc. This is a transient phenomenon that did not impact on continuation of treatment with zinc

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele