Design principles in housing for people with complex physical and cognitive disability: towards an integrated framework for practice

To develop a research-based environmental framework to guide the design and construction of suitable residential dwellings for individuals with complex disability. An environmental approach to housing design and development recognises that there are physical, psychological and social components relating to housing design, dwelling location and the neighbourhood context, and that these elements interact to affect the physical, psychological, and social wellness of individuals. Following theoretical review and synthesis, a comprehensive set of design features that are conducive to residents’ wellness and quality of life are described. It is clear that housing design and development for people with complex disability ought to consider the physical, social, natural, symbolic, and care environment in relation to housing design, dwelling location, and the neighbourhood context for improved housing outcomes. An integrated housing design and development framework is presented. It is hoped this practical matrix/evaluative tool will inform future inclusive housing design and development decisions in Australia and internationally. The application of this framework is especially relevant to political climates striving to achieve design innovation to increase housing choice for people with complex disability

Effect of Fibrin Glue on the Biomechanical Properties of Human Descemet's Membrane

10.1371/journal.pone.0037456PLoS ONE75

Review of the projected impacts of climate change on coastal fishes in southern Africa

The coastal zone represents one of the most economically and ecologically important ecosystems on the planet, none more so than in southern Africa. This manuscript examines the potential impacts of climate change on the coastal fishes in southern Africa and provides some of the first information for the Southern Hemisphere, outside of Australasia. It begins by describing the coastal zone in terms of its physical characteristics, climate, fish biodiversity and fisheries. The region is divided into seven biogeographical zones based on previous descriptions and interpretations by the authors. A global review of the impacts of climate change on coastal zones is then applied to make qualitative predictions on the likely impacts of climate change on migratory, resident, estuarine-dependent and catadromous fishes in each of these biogeographical zones. In many respects the southern African region represents a microcosm of climate change variability and of coastal habitats. Based on the broad range of climate change impacts and life history styles of coastal fishes, the predicted impacts on fishes will be diverse. If anything, this review reveals our lack of fundamental knowledge in this field, in particular in southern Africa. Several research priorities, including the need for process-based fundamental research programs are highlighted

Ozone, NO, and NO2: oxidant air pollutants and more.

This article reviews the acute and chronic toxicity of the three oxidant air pollutants ozone, nitric oxide (NO), and nitrogen dioxide (NO2). The toxicity of binary mixtures of NO2 with other inhaled agents is also discussed. Newer studies are emphasized, especially those published in the last 5 years or still in press. Very recent data from our laboratory that suggest a new cellular mechanism of importance in lung injury in animals exposed to mixtures of ozone and NO2 that may have general relevance with regard to the effects of oxidant air pollutants on the lung are also presented

Use of fine-scale stratigraphy and chemostratigraphy to evaluate conditions of deposition and preservation of a Triassic lagerstätte, south-central Virginia

The rich, fossiliferous Triassic sediments exposed in the Virginia Solite Quarry include a 34-mm-thick “insect layer” that is notable for detailed preservation of soft-bodied invertebrate and vertebrate remains. We describe this unique Konservat-Lagerstätte and use sedimentologic and geochemical analyses to interpret the environmental conditions necessary to preserve such delicate fossils. This work is among the first attempts to apply detailed geochemical/stratigraphic analysis to the study of Lagerstätten and we report on a 332-mm-thick section that includes the insect layer and the rocks immediately below and above it. Our analysis successfully constrains various aspects of the depositional and diagenetic history of the Lagerstätte and permits a detailed analysis of changing conditions prior to, during, and after deposition. Geochemical and sedimentologic analyses of the insect layer and surrounding lithologies reveal a change from siliciclastic-dominated layers (Unit 1) to dolomite-siliciclastic laminites above (Unit 2 and the insect layer), separated by a boundary dolostone layer that is traceable for over 200 m. We interpret this sedimentary shift as the initial stages in the transgression of a shallow, saline, alkaline rift-basin lake over lake margin deposits. The absence of bioturbation by plants and benthic organisms, as well as a lack of predation on the insects, is not explained by significant water depth, but is instead more reasonably considered a result of the chemistry of the water at the lake margin, affected by groundwater seeps, which provided F-, Mg-, and Ca-rich fluids. Although the initial conditions of preservation are remarkable, it is equally impressive that the fossils survived extensive diagenesis, e.g. dissolution of quartz and coarsening of dolomite