1,078 research outputs found
The effect of acoustic fields on the efficiency of solar cells
Acoustic field effects on gallium arsenide, silicon solar cells, and photoresistive devices with and without light exposur
Thomason cohomology of categories
We introduce cohomology and homology theories for small categories with
general coefficient systems from simplex categories first studied by Thomason.
These theories generalize at once Baues-Wirsching cohomology and homology and
other more classical theories. We analyze naturality and functoriality
properties of these theories and construct associated spectral sequences for
functors between small categories.Comment: 22 pages. arXiv admin note: text overlap with arXiv:1112.399
Toxicity of Lunar and Martian Dust Simulants to Alveolar Macrophages Isolated from Human Volunteers
NASA is planning to build a habitat on the Moon and use the Moon as a stepping stone to Mars. JSC-1, an Arizona volcanic ash that has mineral properties similar to lunar soil, is used to produce lunar environments for instrument and equipment testing. NASA is concerned about potential health risks to workers exposed to these fine dusts in test facilities. The potential toxicity of JSC-1 and a Martian soil simulant (JSC-Mars-1, a Hawaiian volcanic ash) was evaluated using human alveolar macrophages (HAM) isolated from volunteers; titanium dioxide and quartz were used as reference dusts. This investigation is a prerequisite to studies of actual lunar dust. HAM were treated in vitro with these test dusts for 24 h; assays of cell viability and apoptosis showed that JSC-1 and TiO2 were comparable, and more toxic than saline control, but less toxic than quartz. HAM treated with JSC-1 or JSC-Mars 1 showed a dose-dependent increase in cytotoxicity. To elucidate the mechanism by which these dusts induce apoptosis, we investigated the involvement of the scavenger receptor (SR). Pretreatment of cells with polyinosinic acid, an SR blocker, significantly inhibited both apoptosis and necrosis. These results suggest HAM cytotoxicity may be initiated by interaction of the dust particles with SR. Besides being cytotoxic, silica is known to induce shifting of HAM phenotypes to an immune active status. The immunomodulatory effect of the simulants was investigated. Treatment of HAM with either simulant caused preferential damage to the suppressor macrophage subpopulation, leading to a net increase in the ratio of activator (RFD1+) to suppressor (RFD1+7+) macrophages, a result similar to treatment with silica. It is recommended that appropriate precautions be used to minimize exposure to these fine dusts in large-scale engineering applications
Eneficial Use of Grasses Artificially Infected with Endophytes, Non-Toxic to Animals
Information presented in this paper demonstrates that Ryegrass Staggers does not occur in animals which graze ryegrasses (Lolium sp.) artificially infected with a strain of Acremonium endophyte which does not produce the tremorgenic toxin lolitrem B. Peramine is produced by the endophyte and this alkaloid protects the grass from attack by Argentine stem weevil. New Zealand farmers have used a ryegrass cultivar infected with this strain of endophyte for the past four years and there are no reports of Ryegrass Staggers in animals grazing it. Strains of endophytes have been found in other grasses which do not produce toxins harmful to animals. It is likely that grasses infected with these strains may have improved growth and persistence and superior animal production compared with grasses which are endophyte-free or infected with non-selected endophytes
Toxicity of lunar dust
The formation, composition and physical properties of lunar dust are
incompletely characterised with regard to human health. While the physical and
chemical determinants of dust toxicity for materials such as asbestos, quartz,
volcanic ashes and urban particulate matter have been the focus of substantial
research efforts, lunar dust properties, and therefore lunar dust toxicity may
differ substantially. In this contribution, past and ongoing work on dust
toxicity is reviewed, and major knowledge gaps that prevent an accurate
assessment of lunar dust toxicity are identified. Finally, a range of studies
using ground-based, low-gravity, and in situ measurements is recommended to
address the identified knowledge gaps. Because none of the curated lunar
samples exist in a pristine state that preserves the surface reactive chemical
aspects thought to be present on the lunar surface, studies using this material
carry with them considerable uncertainty in terms of fidelity. As a
consequence, in situ data on lunar dust properties will be required to provide
ground truth for ground-based studies quantifying the toxicity of dust exposure
and the associated health risks during future manned lunar missions.Comment: 62 pages, 9 figures, 2 tables, accepted for publication in Planetary
and Space Scienc
The origins of Atlantic salmon (Salmo salar L.) recolonizing the River Mersey in northwest England.
notes: PMCID: PMC3492779types: Journal Article© 2012 The Authors. Ecology and Evolution published by Blackwell Publishing Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.By the 1950s, pollution had extirpated Atlantic salmon in the river Mersey in northwest England. During the 1970s, an extensive restoration program began and in 2001, an adult salmon was caught ascending the river. Subsequently, a fish trap was installed and additional adults are now routinely sampled. In this study, we have genotyped 138 adults and one juvenile salmon at 14 microsatellite loci from across this time period (2001-2011). We have used assignment analysis with a recently compiled pan-European microsatellite baseline to identify their most probable region of origin. Fish entering the Mersey appear to originate from multiple sources, with the greatest proportion (45-60%, dependent on methodology) assigning to rivers in the geographical region just north of the Mersey, which includes Northwest England and the Solway Firth. Substantial numbers also appear to originate from rivers in western Scotland, and from rivers in Wales and Southwest England; nonetheless, the number of fish originating from proximal rivers to the west of the Mersey was lower than expected. Our results suggest that the majority of salmon sampled in the Mersey are straying in a southerly direction, in accordance with the predominantly clockwise gyre present in the eastern Irish Sea. Our findings highlight the complementary roles of improving water quality and in-river navigability in restoring salmon to a river and underlines further the potential benefits of restoration over stocking as a long-term solution to declining fish stocks.The Environment Agency (England & Wales)The Game and Wildlife Conservation TrustThe Westcountry Rivers TrustThe University of Exete
Indicators of Pathogen Potential of Pasture Soils
A simple pot test was used to indicate the combined effects of several pathogens common in pasture soils (plant parasitic nematodes and pathogenic fungi e.g. Pythium spp.) by comparing the dry weight yields of clover seedlings grown in untreated soil with those from soil treated in a microwave oven. Response to microwave treatment, expressed as a Soil Pathogenicity Index , was greater with soil from old pasture or from areas in 2 year old pasture plots showing poor regrowth after grazing of white clover (Trifolium repens L) or Caucasian clover (T. ambiguum Bieb.), than from soil from new pasture or areas in the 2 year old plots with vigorous clover regrowth
Evidence for adaptive introgression of exons across a hybrid swarm in deer
Background: Secondary contact between closely related lineages can result in a variety of outcomes, including hybridization, depending upon the strength of reproductive barriers. By examining the extent to which different parts of the genome introgress, it is possible to infer the strength of selection and gain insight into the evolutionary trajectory of lineages. Following secondary contact approximately 8000 years ago in the Pacific Northwest, mule deer (Odocoileus hemionus hemionus) and black-tailed deer (O. h. columbianus) formed a hybrid swarm along the Cascade mountain range despite substantial differences in body size (up to two times) and habitat preference. In this study, we examined genetic population structure, extent of introgression, and selection pressures in freely interbreeding populations of mule deer and black-tailed deer using mitochondrial DNA sequences, 9 microsatellite loci, and 95 SNPs from protein-coding genes.
Results: We observed bi-directional hybridization and classified approximately one third of the 172 individuals as hybrids, almost all of which were beyond the F1 generation. High genetic differentiation between black-tailed deer and mule deer at protein-coding genes suggests that there is positive divergent selection, though selection on these loci is relatively weak. Contrary to predictions, there was not greater selection on protein-coding genes thought to be associated with immune function and mate choice. Geographic cline analyses were consistent across genetic markers, suggesting long-term stability (over hundreds of generations), and indicated that the center of the hybrid swarm is 20-30 km to the east of the Cascades ridgeline, where there is a steep ecological transition from wet, forested habitat to dry, scrub habitat.
Conclusions: Our data are consistent with a genetic boundary between mule deer and black-tailed deer that is porous but maintained by many loci under weak selection having a substantial cumulative effect. The absence of clear reproductive barriers and the consistent centering of geographic clines at a sharp ecotone suggests that ecology is a driver of hybrid swarm dynamics. Adaptive introgression in this study (and others) promotes gene flow and provides valuable insight into selection strength on specific genes and the evolutionary trajectory of hybridizing taxa
- …
