Promising Practices: Advanced Referral System - Illinois Division of Rehabilitation Services, BPA&O Project Human Services Center

Changes in disability policy at the state and federal level have presented many new opportunities for meaningful systems change and services delivery for people with disabilities. Since 2000, the Social Security Administration, the U.S. Department of Labor, the Centers for Medicare & Medicaid Services and the Rehabilitation Services Administration have issued many grants to state agencies, community-based service providers and advocates to address barriers to employment for people with disabilities. Many of these grants have competitive employment as the goal, yet very few of these grants have built in support for benefits planning and assistance – a function that many believe is critical to achieving competitive employment. In this Promising Practices, the Illinois Division of Rehabilitation Services BPA&O Project (DRS BPA&O Project) and the Human Services Center (HSC), a community-based mental health center and the recipient of a DOL Customized Employment Grant, created a model partnership to ensure that the 600 consumers with severe mental illness served by HSC under their grant would gain access to benefits planning services. They call their model partnership an “Advanced Referral System.

Quasi-Periodic Pulsations during the Impulsive and Decay phases of an X-class Flare

Quasi-periodic pulsations (QPP) are often observed in X-ray emission from solar flares. To date, it is unclear what their physical origins are. Here, we present a multi-instrument investigation of the nature of QPP during the impulsive and decay phases of the X1.0 flare of 28 October 2013. We focus on the character of the fine structure pulsations evident in the soft X-ray time derivatives and compare this variability with structure across multiple wavelengths including hard X-ray and microwave emission. We find that during the impulsive phase of the flare, high correlations between pulsations in the thermal and non-thermal emissions are seen. A characteristic timescale of ~20s is observed in all channels and a second timescale of ~55s is observed in the non-thermal emissions. Soft X-ray pulsations are seen to persist into the decay phase of this flare, up to 20 minutes after the non-thermal emission has ceased. We find that these decay phase thermal pulsations have very small amplitude and show an increase in characteristic timescale from ~40s up to ~70s. We interpret the bursty nature of the co-existing multi-wavelength QPP during the impulsive phase in terms of episodic particle acceleration and plasma heating. The persistent thermal decay phase QPP are most likely connected with compressive MHD processes in the post-flare loops such as the fast sausage mode or the vertical kink mode.Comment: 7 pages, 4 figures, 1 tabl

Examining hope as a transdiagnostic mechanism of change across anxiety disorders and CBT treatment protocols.

Hope is a trait that represents the capacity to identify strategies or pathways to achieve goals and the motivation or agency to effectively pursue those pathways. Hope has been demonstrated to be a robust source of resilience to anxiety and stress and there is limited evidence that, as has been suggested for decades, hope may function as a core process or transdiagnostic mechanism of change in psychotherapy. The current study examined the role of hope in predicting recovery in a clinical trial in which 223 individuals with 1 of 4 anxiety disorders were randomized to transdiagnostic cognitive behavior therapy (CBT), disorder-specific CBT, or a waitlist controlled condition. Effect size results indicated moderate to large intraindividual increases in hope, that changes in hope were consistent across the five CBT treatment protocols, that changes in hope were significantly greater in CBT relative to waitlist, and that changes in hope began early in treatment. Results of growth curve analyses indicated that CBT was a robust predictor of trajectories of change in hope compared to waitlist, and that changes in hope predicted changes in both self-reported and clinician-rated anxiety. Finally, a statistically significant indirect effect was found indicating that the effects of treatment on changes in anxiety were mediated by treatment effects on hope. Together, these results suggest that hope may be a promising transdiagnostic mechanism of change that is relevant across anxiety disorders and treatment protocols.R01 MH090053 - NIMH NIH HHSAccepted manuscrip

Advances in autophagy regulatory mechanisms

Autophagy plays a critical role in cell metabolism by degrading and recycling internal components when challenged with limited nutrients. This fundamental and conserved mechanism is based on a membrane trafficking pathway in which nascent autophagosomes engulf cytoplasmic cargo to form vesicles that transport their content to the lysosome for degradation. Based on this simple scheme, autophagy modulates cellular metabolism and cytoplasmic quality control to influence an unexpectedly wide range of normal mammalian physiology and pathophysiology. In this review, we summarise recent advancements in three broad areas of autophagy regulation. We discuss current models on how autophagosomes are initiated from endogenous membranes. We detail how the uncoordinated 51-like kinase (ULK) complex becomes activated downstream of mechanistic target of rapamycin complex 1 (MTORC1). Finally, we summarise the upstream signalling mechanisms that can sense amino acid availability leading to activation of MTORC1

Grey and white matter differences in Chronic Fatigue Syndrome : A voxel-based morphometry study

Conflicts of interest and source of funding The authors declare no conflicts of interest. This research was funded by the Medical Research Council (MR/J002712/1). AF is supported by Research Capability Funding from the Newcastle upon Tyne Hospitals NHS Foundation Trust and the Northumberland, Tyne and Wear NHS Foundation Trust.Peer reviewedPublisher PD

Detection and Interpretation Of Long-Lived X-Ray Quasi-Periodic Pulsations in the X-Class Solar Flare On 2013 May 14

Quasi-periodic pulsations (QPP) seen in the time derivative of the GOES soft X-ray light curves are analyzed for the near-limb X3.2 event on 14 May 2013. The pulsations are apparent for a total of at least two hours from the impulsive phase to well into the decay phase, with a total of 163 distinct pulses evident to the naked eye. A wavelet analysis shows that the characteristic time scale of these pulsations increases systematically from $\sim$25 s at 01:10 UT, the time of the GOES peak, to $\sim$100 s at 02:00 UT. A second ridge in the wavelet power spectrum, most likely associated with flaring emission from a different active region, shows an increase from $\sim$40 s at 01:40 UT to $\sim$100 s at 03:10 UT. We assume that the QPP that produced the first ridge result from vertical kink-mode oscillations of the newly formed loops following magnetic reconnection in the coronal current sheet. This allows us to estimate the magnetic field strength as a function of altitude given the density, loop length, and QPP time scale as functions of time determined from the GOES light curves and RHESSI images. The calculated magnetic field strength of the newly formed loops ranges from about $\sim$500 G at an altitude of 24 Mm to a low value of $\sim$10 G at 60 Mm, in general agreement with the expected values at these altitudes. Fast sausage mode oscillations are also discussed and cannot be ruled out as an alternate mechanism for producing the QPP

The Ultraviolet and Infrared Star Formation Rates of Compact Group Galaxies: An Expanded Sample

Compact groups of galaxies provide insight into the role of low-mass, dense environments in galaxy evolution because the low velocity dispersions and close proximity of galaxy members result in frequent interactions that take place over extended timescales. We expand the census of star formation in compact group galaxies by \citet{tzanavaris10} and collaborators with Swift UVOT, Spitzer IRAC and MIPS 24 \micron\ photometry of a sample of 183 galaxies in 46 compact groups. After correcting luminosities for the contribution from old stellar populations, we estimate the dust-unobscured star formation rate (SFR$_{\mathrm{UV}}$) using the UVOT uvw2photometry. Similarly, we use the MIPS 24 \micron\ photometry to estimate the component of the SFR that is obscured by dust (SFR$_{\mathrm{IR}}$). We find that galaxies which are MIR-active (MIR-"red"), also have bluer UV colours, higher specific star formation rates, and tend to lie in H~{\sc i}-rich groups, while galaxies that are MIR-inactive (MIR-"blue") have redder UV colours, lower specific star formation rates, and tend to lie in H~{\sc i}-poor groups. We find the SFRs to be continuously distributed with a peak at about 1 M$_{\odot}$ yr$^{-1}$, indicating this might be the most common value in compact groups. In contrast, the specific star formation rate distribution is bimodal, and there is a clear distinction between star-forming and quiescent galaxies. Overall, our results suggest that the specific star formation rate is the best tracer of gas depletion and galaxy evolution in compact groups.Comment: 19 pages, 17 figure

Dissociable effects of tryptophan supplementation on negative feedback sensitivity and reversal learning

Serotonin has been shown to modulate probabilistic reversal learning (PRL) and negative feedback sensitivity (NFS) in both animal and human studies. Whilst these two measures are tightly coupled, some studies have suggested that these may be mediated by independent mechanisms; the former, representing perseveration and cognitive flexibility, and the latter measuring the ability to maintain a response set (win-stay) at the expense of lose-shift behaviour when occasional misleading feedback has been presented. Here, we tested this hypothesis in 44 healthy participants who were administered tryptophan (22 placebo, 22 tryptophan), a presynaptic precursor to serotonin. We found a dissociable effect of tryptophan supplementation on PRL/NFS. Specifically, tryptophan administration increased NFS compared to the placebo group but had no effect on PRL. We discuss these findings in relation to presynaptic and postsynaptic mechanisms, receptor specificity, and dosage and with a particular focus on the acute tryptophan depletion (ATD) procedures

De novo post-diagnosis statin use, breast cancer-specific and overall mortality in women with stage I-III breast cancer.

BACKGROUND: Prior evidence suggests a role for statins in the management of cancer. However, the benefit of statin use in the adjuvant setting remains uncertain. This study investigates associations between statin use initiated after a breast cancer diagnosis and mortality. METHODS: Women with stage I-III breast cancer were identified from the National Cancer Registry of Ireland (N=4243). Post-diagnostic statin initiators were identified from pharmacy claims data (N=837). Multivariate models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between de novo statin use and mortality. RESULTS: The median duration of statin use was 6.7 years. No association was found between post-diagnostic statin use and breast cancer-specific (HR 0.88, 95% CI 0.66, 1.17) or all-cause mortality (HR 1.00, 95% CI 0.82, 1.21). CONCLUSIONS: The results from our study suggest that initiating statin use after a diagnosis of stage I-III breast cancer is not associated with a reduction in breast cancer-specific mortality