The use of nano-robots in medicine

Today, more and more people question the treatment without surgery. Thanks to modern research and the efforts of scientists a new possible way to use nano-robots was invented. The first thing to know about nanorobots in medicine is that they're not like the robots you're probably imagining. Scientists who build nanorobots are building tiny packages that can complete tasks in an automated way

Вплив материнського коду на формування україномовної особистості в сучасній родині

Зростання дитини та засвоєння нею мови починається з сім’ї, яка була і є оберегом наших виховних традицій, цінностей, культури та звичаїв. Саме живе слово, у якому закладений материнський код, є необхідною умовою формування україномовної особистості в сучасній родині. У процесі спілкування дитини з матір’ю відбувається підключення до рідномовного коду, закладеного ще на генетичному рівні. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/3472

Поняття "материнська" та "рідна" мова в сучасному двомовному суспільстві

Подаються результати опитування студентів кафедри журналістики та філології СумДУ щодо понять «материнська мова», «рідна мова» та чинників, які впливають на процес формування мовної особистості українця в двомовному суспільстві

Open educational resources: some usage aspects

Openness is one of the most influential drivers of change in education and training today, especially for educational organizations both in adult learning as well as in higher education. Open educational resources (ОER) as a manifestation of the principle of openness is gradually becoming an integral part of the educational environment in higher education. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2942

Improving the quality of educational content by means of the complex of open social resources

Blended learning contributes to the increase of students' independent work efficiency through the use of e-learning content. Quality of educational content, which a student personally works with, greatly influences the efficiency of his work in the classroom and results of mastering the discipline in general. The use of e-learning materials in open access contributes not only to their accessibility, but also creates preconditions to improve their quality. Due to the involvement of a great number of students and teachers a deep content analysis and its further qualitative development becomes possible

Software implementation of calculating the value of a logical expression in compilers

This paper describes an algorithm to optimize a process of determining the value of a logical expression. This algorithm is based on the principles of the algebra of logic, graphs and automata theory. Fast calculation of a logical expression is achieved by a reduction in the number of operations. The program is a multi-functional simulator

The use of nano-robots in medicine

Today, more and more people question the treatment without surgery. Thanks to modern research and the efforts of scientists a new possible way to use nano-robots was invented. The first thing to know about nanorobots in medicine is that they're not like the robots you're probably imagining. Scientists who build nanorobots are building tiny packages that can complete tasks in an automated way

PREOPERATIVE REVELATION OF INSULIN RESISTANCE AS A CRITERION OF DEBULKING NECESSITY IN PATIENTS WITH OBESITY

The article considers the questions of a necessity of widening the list of obligatory preoperative examinations of patients with obesity for the choice of adequate operation volume, especially for simultaneous debulking of a greater omentum. The aim of research is an estimation of possibility of using an insulin resistance index (НОМА – IR) as a necessity criterion of simultaneous debulking of a greater omentum at operative interventions in patients with obesity. There were examined 60 persons from the surgical stationary, divided in 2 groups. 1 group included 20 patients with the normal body mass, 2 – 40 patients with different degrees of obesity. Insulin resistance was revealed on the base of glucose and insulin estimation, HOMA-IR index calculation. It was revealed, that glucose level in all patients doesn’t reliably exceeds the upper threshold of norm, insulin rates don’t differ from the control ones, even in patients with obesity, and rise in 20 % of patients only at 3 degree of obesity. It creates an illusion about the normal state of carbohydrate metabolism in these patients, whereas insulin resistance index estimation allows to reveal a pre-clinic stage of these disorders and to make a timely decision as to a possibility and necessity of simultaneous palliative operation as an ometnectomy that doesn’t complicate a course of operation and postoperational period, but allows to decrease an expressiveness of carbohydrate metabolism disorders at obesity. The standard preoperative estimation of glucose level in blood doesn’t allow to diagnose an insulin resistance state, that is patients of the high risk group of metabolic syndrome development (especially the ones with obesity) need the additional insulin estimation and insulin resistance index calculation in preoperational period

Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Troetschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Boenigk, W., Koerschen, H. G., Mueller, A., Poetsch, A., Rennhack, A., Gui, L., Nicastro, D., Struenker, T., Seifert, R., & Kaupp, U. B. Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation. Embo Journal, 39(4), (2020): e102723, doi:10.15252/embj.2019102723.Cilia serve as cellular antennae that translate sensory information into physiological responses. In the sperm flagellum, a single chemoattractant molecule can trigger a Ca2+ rise that controls motility. The mechanisms underlying such ultra‐sensitivity are ill‐defined. Here, we determine by mass spectrometry the copy number of nineteen chemosensory signaling proteins in sperm flagella from the sea urchin Arbacia punctulata. Proteins are up to 1,000‐fold more abundant than the free cellular messengers cAMP, cGMP, H+, and Ca2+. Opto‐chemical techniques show that high protein concentrations kinetically compartmentalize the flagellum: Within milliseconds, cGMP is relayed from the receptor guanylate cyclase to a cGMP‐gated channel that serves as a perfect chemo‐electrical transducer. cGMP is rapidly hydrolyzed, possibly via “substrate channeling” from the channel to the phosphodiesterase PDE5. The channel/PDE5 tandem encodes cGMP turnover rates rather than concentrations. The rate‐detection mechanism allows continuous stimulus sampling over a wide dynamic range. The textbook notion of signal amplification—few enzyme molecules process many messenger molecules—does not hold for sperm flagella. Instead, high protein concentrations ascertain messenger detection. Similar mechanisms may occur in other small compartments like primary cilia or dendritic spines.We thank Heike Krause for preparing the manuscript. Financial support by the Deutsche Forschungsgemeinschaft (DFG) via the priority program SPP 1726 “Microswimmers” and the Cluster of Excellence 1023 “ImmunoSensation” is gratefully acknowledged. We thank D. Stoddard for management of the UTSW cryo‐electron microscope facility, which is funded in part by a Cancer Prevention and Research Institute of Texas (CPRIT) Core Facility Award (RP170644). This study was supported by HHS|National Institutes of Health (NIH) grant R01 GM083122 and by CPRIT grant RR140082 to D. Nicastro