\u3cem\u3eBeyond Therapy\u3c/em\u3e: A Dramaturgical Look at Christopher Durang\u27s Absurdist Play

This research notebook (also known as a dramaturgy notebook) was created as a class project for an advanced Theatre History course. We were asked to choose one play to study throughout the semester with the ultimate goal of creating a dramaturgy notebook that would be usable for a production team were we to produce our show of choice. Having a great interest in Christopher Durang and his work, I chose to study Beyond Therapy. We were asked specifically to write a biography on our chosen playwright, a historical context essay, an essay about themes present in the show, and an essay commenting on published criticisms on various performances of the show. Beyond that, we were also asked to write two supplements that might be found in a dramaturgy notebook. For this portion of the assignment I chose to write a press release covering the fictional Linfield production, and to create a question and answer section culminating in some interview questions published on Durang’s website. While the notebook as a whole serves to provide context for a production team, each section of the notebook has its own stand-alone function. In 2014, this research was presented at the Kennedy Center American College Theatre Festival (Region VII) in Boise, Idaho and was awarded first runner-up in the dramaturgy category

A Statistical Analysis of RNA Folding Algorithms Through Thermodynamic Parameter Perturbation

Computational RNA secondary structure prediction is rather well established. However, such prediction algorithms always depend on a large number of experimentally measured parameters. Here, we study how sensitive structure prediction algorithms are to changes in these parameters. We find that already for changes corresponding to the actual experimental error to which these parameters have been determined 30% of the structure are falsly predicted and the ground state structure is preserved under parameter perturbation in only 5% of all cases. We establish that base pairing probabilities calculated in a thermal ensemble are a viable though not perfect measure for the reliability of the prediction of individual structure elements. A new measure of stability using parameter perturbation is proposed, and its limitations discussed.Comment: 6 pages, 3 figures, 1 table submitted to Nucleic Acids Researc

Cell volume regulation in the proximal tubule of rat kidney proximal tubule cell volume regulation

We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment. We examined whether regulatory volume decrease (RVD), which follows exposure to a hyposmotic peritubular solution, can be achieved solely via stimulation of basolateral K^+ and Cl^− channels and Na^+–HCO₃^− cotransporters. We also determined whether regulatory volume increase (RVI), which follows exposure to a hyperosmotic peritubular solution under certain conditions, may be accomplished by activating basolateral Na^+/H^+ exchangers. Model predictions were in good agreement with experimental observations in mouse proximal tubule cells assuming that a 10% increase in cell volume induces a fourfold increase in the expression of basolateral K+ and Cl− channels and Na+–HCO₃^− cotransporters. Our results also suggest that in response to a hyposmotic challenge and subsequent cell swelling, Na^+–HCO₃^− cotransporters are more efficient than basolateral K^+ and Cl^− channels at lowering intracellular osmolality and reducing cell volume. Moreover, both RVD and RVI are predicted to stabilize net transcellular Na^+ reabsorption, that is, to limit the net Na^+ flux decrease during a hyposmotic challenge or the net Na^+ flux increase during a hyperosmotic challenge.This research was supported by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, via grant R01DK106102 to AT Layton. (R01DK106102 - National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases)Accepted manuscrip

Satellite Power Systems (SPS) Space Transportation Workshop Summary

Space transportation requirements are major elements in the technical and economic realization of the entire SPS concept. First, steps in enhancing the shuttle include the Titan based liquid boost module (LBM) and liquid propellant boosters (LPB) to replace the present solid rocket boosters (SRB). The next choice between new ballistic or winged boosters must still be made; as well as the choice between series (staged) and parallel operation. Entirely new vehicles of large size are required before the economic and environmental problems of the prototype, or even demonstration, SPS can be resolved. Social impacts such as noise, and atmospheric pollution, locally and in the ionosphere, must be fully addressed. Although rather advanced technology and well developed operational management is required to properly target the average cost of gross cargo payloads into LEO at 30 $(1979)/kg for the construction of the initial SPS, the further goal for repetitive construction of 30 to 60 SPS at 15$ (1979)/kg for all operational payloads require the use of very advanced, long lived vehicles with a sophisticated operational organization using off shore, equatorial launch sites

Philanthropy and the Third Sector in Mexico: The Enabling Environment and Its Limitations

Why is Mexico's third sector underdeveloped? Despite the importance of this question, there is no persuasive answer. The usual mono-causal explanations –such as historical trajectory or lack of civic culture– are inadequate. A better way to address this question is applying the concept of an enabling environment for civil society. This encompasses empowering legal and fiscal frameworks, an effective accountability system, adequate institutional capacity of organizations, and availability of resources. The article offers an assessment of where Mexico stands in relation to these five components and argues that on each count they are unfavorable and/or underdeveloped. In addition, the author argues for including a sixth element: the cultural context for philanthropy and civil society. Based on original survey results, he demonstrates that key values and habits inhibit efforts to strengthen civil society and must be taken into account in any effort to understand or change the status quo. The article concludes with a reflection on how Mexican civil society can begin to change its unfavorable context, beginning with the need for stronger mechanisms for greater accountability on the part of organizations

Incentive Payment Programs for Environmental Protection: A Framework for Eliciting and Estimating Landowners' Willingness to Participate

This paper considers the role of incentive payment programs in eliciting, estimating, and predicting landowners’ conservation enrollments. Using both program participation and the amount of land enrolled, we develop two econometric approaches for predicting enrollments. The first is a multivariate censored regression model that handles zero enrollments and heterogeneity in the opportunity cost of enrollments by combining an inverse hyperbolic sine transformation of enrollments with alternative-specific correlation and random parameters. The second is a beta-binomial model, which recognizes that in practice elicited enrollments are essentially integer valued. We apply these approaches to Finland, where the protection of private nonindustrial forests is an important environmental policy problem. We compare both econometric approaches via cross-validation and find that the beta-binomial model predicts as well as the multivariate censored model yet has fewer parameters. The beta-binomial model also facilitates policy predictions and simulations, which we use to illustrate the framework.protection, endangered, voluntary, incentive, tobit, beta-binomial, stated preferences

Neural dynamics of feedforward and feedback processing in figure-ground segregation

Determining whether a region belongs to the interior or exterior of a shape (figure-ground segregation) is a core competency of the primate brain, yet the underlying mechanisms are not well understood. Many models assume that figure-ground segregation occurs by assembling progressively more complex representations through feedforward connections, with feedback playing only a modulatory role. We present a dynamical model of figure-ground segregation in the primate ventral stream wherein feedback plays a crucial role in disambiguating a figure's interior and exterior. We introduce a processing strategy whereby jitter in RF center locations and variation in RF sizes is exploited to enhance and suppress neural activity inside and outside of figures, respectively. Feedforward projections emanate from units that model cells in V4 known to respond to the curvature of boundary contours (curved contour cells), and feedback projections from units predicted to exist in IT that strategically group neurons with different RF sizes and RF center locations (teardrop cells). Neurons (convex cells) that preferentially respond when centered on a figure dynamically balance feedforward (bottom-up) information and feedback from higher visual areas. The activation is enhanced when an interior portion of a figure is in the RF via feedback from units that detect closure in the boundary contours of a figure. Our model produces maximal activity along the medial axis of well-known figures with and without concavities, and inside algorithmically generated shapes. Our results suggest that the dynamic balancing of feedforward signals with the specific feedback mechanisms proposed by the model is crucial for figure-ground segregation