Sensorless second order sliding mode observer for induction motor

International audienceIn this paper, a second order sliding mode observer for the induction motor without mechanical sensor is presented. This observer converges in finite time and is robust to the variation of parameters. Using Matlab/Simulink, the simulation results show the performance of the proposed observer. Furthermore, an industrial application is presented in order to highlight the technological interest of the proposed method and also show the difficulties due to real time computation constraints

Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs)

BACKGROUND: Although patients with advanced or metastatic lung cancer have poor prognosis, admission to the ICU for management of life-threatening complications has increased over the years. Patients with newly diagnosed lung cancer appear as good candidates for ICU admission, but more robust information to assist decisions is lacking. The aim of our study was to evaluate the prognosis of newly diagnosed unresectable lung cancer patients. METHODS: A retrospective multicentric study analyzed the outcome of patients admitted to the ICU with a newly diagnosed lung cancer (diagnosis within the month) between 2010 and 2013. RESULTS: Out of the 100 patients, 30 had small cell lung cancer (SCLC) and 70 had non-small cell lung cancer. (Thirty patients had already been treated with oncologic treatments.) Mechanical ventilation (MV) was performed for 81 patients. Seventeen patients received emergency chemotherapy during their ICU stay. ICU, hospital, 3- and 6-month mortality were, respectively, 47, 60, 67 and 71%. Hospital mortality was 60% when invasive MV was used alone, 71% when MV and vasopressors were needed and 83% when MV, vasopressors and hemodialysis were required. In multivariate analysis, hospital mortality was associated with metastatic disease (OR 4.22 [1.4-12.4]; p = 0.008), need for invasive MV (OR 4.20 [1.11-16.2]; p = 0.030), while chemotherapy in ICU was associated with survival (OR 0.23, [0.07-0.81]; p = 0.020). CONCLUSION: This study shows that ICU management can be appropriate for selected newly diagnosed patients with advanced lung cancer, and chemotherapy might improve outcome for patients with SCLC admitted for cancer-related complications. Nevertheless, tumors' characteristics, numbers and types of organ dysfunction should be taken into account in the decisional process before admitting these patients in ICU.Peer reviewe

Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients

Ataxia with oculomotor apraxia type 2 (AOA2) is an autosomal recessive disease due to mutations in the senataxin gene, causing progressive cerebellar ataxia with peripheral neuropathy, cerebellar atrophy, occasional oculomotor apraxia and elevated alpha-feto-protein (AFP) serum level. We compiled a series of 67 previously reported and 58 novel ataxic patients who underwent senataxin gene sequencing because of suspected AOA2. An AOA2 diagnosis was established for 90 patients, originating from 15 countries worldwide, and 25 new senataxin gene mutations were found. In patients with AOA2, median AFP serum level was 31.0 mu g/l at diagnosis, which was higher than the median AFP level of AOA2 negative patients: 13.8 mu g/l, P = 0.0004; itself higher than the normal level (3.4 mu g/l, range from 0.5 to 17.2 mu g/l) because elevated AFP was one of the possible selection criteria. Polyneuropathy was found in 97.5% of AOA2 patients, cerebellar atrophy in 96%, occasional oculomotor apraxia in 51%, pyramidal signs in 20.5%, head tremor in 14%, dystonia in 13.5%, strabismus in 12.3% and chorea in 9.5%. No patient was lacking both peripheral neuropathy and cerebellar atrophy. The age at onset and presence of occasional oculomotor apraxia were negatively correlated to the progression rate of the disease (P = 0.03 and P = 0.009, respectively), whereas strabismus was positively correlated to the progression rate (P = 0.03). An increased AFP level as well as cerebellar atrophy seem to be stable in the course of the disease and to occur mostly at or before the onset of the disease. One of the two patients with a normal AFP level at diagnosis had high AFP levels 4 years later, while the other had borderline levels. The probability of missing AOA2 diagnosis, in case of sequencing senataxin gene only in non-Friedreich ataxia non-ataxia-telangiectasia ataxic patients with AFP level >= 7 mu g/l, is 0.23% and the probability for a non-Friedreich ataxia non-ataxia-telangiectasia ataxic patient to be affected with AOA2 with AFP levels >= 7 mu g/l is 46%. Therefore, selection of patients with an AFP level above 7 mu g/l for senataxin gene sequencing is a good strategy for AOA2 diagnosis. Pyramidal signs and dystonia were more frequent and disease was less severe with missense mutations in the helicase domain of senataxin gene than with missense mutations out of helicase domain and deletion and nonsense mutations (P = 0.001, P = 0.008 and P = 0.01, respectively). The lack of pyramidal signs in most patients may be explained by masking due to severe motor neuropathy

Évaluation expérimentale d'un système statistique de synthèse de la parole, HTS, pour la langue française

Les travaux présentés dans cette thèse se situent dans le cadre de la synthèse de la parole à partir du texte et, plus précisément, dans le cadre de la synthèse paramétrique utilisant des règles statistiques. Nous nous intéressons à l'influence des descripteurs linguistiques utilisés pour caractériser un signal de parole sur la modélisation effectuée dans le système de synthèse statistique HTS. Pour cela, deux méthodologies d'évaluation objective sont présentées. La première repose sur une modélisation de l'espace acoustique, généré par HTS par des mélanges gaussiens (GMM). En utilisant ensuite un ensemble de signaux de parole de référence, il est possible de comparer les GMM entre eux et ainsi les espaces acoustiques générés par les différentes configurations de HTS. La seconde méthodologie proposée repose sur le calcul de distances entre trames acoustiques appariées pour pouvoir évaluer la modélisation effectuée par HTS de manière plus locale. Cette seconde méthodologie permet de compléter les diverses analyses en contrôlant notamment les ensembles de données générées et évaluées. Les résultats obtenus selon ces deux méthodologies, et confirmés par des évaluations subjectives, indiquent que l'utilisation d'un ensemble complexe de descripteurs linguistiques n'aboutit pas nécessairement à une meilleure modélisation et peut s'avérer contre-productif sur la qualité du signal de synthèse produit.The work presented in this thesis is about TTS speech synthesis and, more particularly, about statistical speech synthesis for French. We present an analysis on the impact of the linguistic contextual factors on the synthesis achieved by the HTS statistical speech synthesis system. To conduct the experiments, two objective evaluation protocols are proposed. The first one uses Gaussian mixture models (GMM) to represent the acoustical space produced by HTS according to a contextual feature set. By using a constant reference set of natural speech stimuli, GMM can be compared between themselves and consequently acoustic spaces generated by HTS. The second objective evaluation that we propose is based on pairwise distances between natural speech and synthetic speech generated by HTS. Results obtained by both protocols, and confirmed by subjective evaluations, show that using a large set of contextual factors does not necessarily improve the modeling and could be counter-productive on the speech quality.RENNES1-Bibl. électronique (352382106) / SudocSudocFranceF

Is there a role for melatonin in fibromyalgia?

Fibromyalgia, characterised by persistent pain, fatigue, sleep disturbance and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis. Heterogeneity of clinical expression of fibromyalgia with a multifactorial aetiology has made the development of effective therapeutic strategies challenging. Physiological properties of the neurohormone melatonin appear related to the symptom profile exhibited by patients with fibromyalgia and thus disturbance of it’s production would be compatible with the pathophysiology. Altered levels of melatonin have been observed in patients with fibromyalgia which are associated with lower secretion during dark hours and higher secretion during daytime. However, inconsistencies of available clinical evidence limit conclusion of a relationship between levels of melatonin and symptom profiles in patients with fibromyalgia. Administration of melatonin to patients with fibromyalgia has demonstrated suppression of many symptoms and an improved quality of life consistent with benefit as a therapy for the management of this condition. Further studies with larger samples, however, are required to explore the potential role of melatonin in the pathophysiology of fibromyalgia and determine the optimal dosing regimen of melatonin for the management of fibromyalgia

PRIM project: what contributions for disabilities?

In the PRIM project, we aim at giving people the power to create scenagrams (interaction scenarios between a human and digital devices) without the need to learn programming or to ask for computer scientists. In this project, software design follows an unconventional approach, far from classical codes, to embody human thinking (based on interactions) instead of computer logic (based on algorithms). The main idea rests on a new time representation using a PRIM-specific timeline instead of a standardized timeline. We evaluated acceptability and cognitive compatibility of this new timeline with 50 participants. Results are very promising. In this paper, we detail qualitative evaluation results about the interest of such software in the field of disability.Comment: in French language, Handicap 2022, Jun 2022, Paris, Franc

Illuminating subduction zone rheological properties in the wake of a giant earthquake

Deformation associated with plate convergence at subduction zones is accommodated by a complex system involving fault slip and viscoelastic flow. These processes have proven difficult to disentangle. The 2010 Mw 8.8 Maule earthquake occurred close to the Chilean coast within a dense network of continuously recording Global Positioning System stations, which provide a comprehensive history of surface strain. We use these data to assemble a detailed picture of a structurally controlled megathrust fault frictional patchwork and the three-dimensional rheological and time-dependent viscosity structure of the lower crust and upper mantle, all of which control the relative importance of afterslip and viscoelastic relaxation during postseismic deformation. These results enhance our understanding of subduction dynamics including the interplay of localized and distributed deformation during the subduction zone earthquake cycle

Node and junction box services and interfaces for a local sea bottom observatory

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