Therapeutic targeting of cathepsin C::from pathophysiology to treatment

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl aminopeptidase. The best characterized physiological function of CatC is the activation of pro-inflammatory granule-associated serine proteases. These proteases are synthesized as inactive zymogens containing an N-terminal pro-dipeptide, which maintains the zymogen in its inactive conformation and prevents premature activation, which is potentially toxic to the cell. The activation of serine protease zymogens occurs through cleavage of the N-terminal dipeptide by CatC during cell maturation in the bone marrow. In vivo data suggest that pharmacological inhibition of pro-inflammatory serine proteases would suppress or attenuate deleterious effects of inflammatory/auto-immune disorders mediated by these proteases. The pathological deficiency in CatC is associated with Papillon-Lefèvre syndrome. The patients however do not present marked immunodeficiency despite the absence of active serine proteases in immune defense cells. Hence, the transitory pharmacological blockade of CatC activity in the precursor cells of the bone marrow may represent an attractive therapeutic strategy to regulate activity of serine proteases in inflammatory and immunologic conditions. A variety of CatC inhibitors have been developed both by pharmaceutical companies and academic investigators, some of which are currently being employed and evaluated in preclinical/clinical trials

A Site(s)-Specific Digital Archive : Fostering Embodied and Creative Use of The Poster Archive at Teatermuseet in Malmö

This thesis project explores how interaction design can assist in preserving and making accessible the cultural heritage of theatre in Skåne, by collaborating with Teatermuseet in Malmö. The research seeks to answer how the collection of posters belonging to the museum can be made more accessible to a wider audience and how creativity can be used as an accelerator for designing immersive digital-tangible concepts for archiving. This is done by examining the evolving landscape of the sector of Galleries, Libraries, Archives and Museums, the challenges and opportunities presented by digital archiving, and the role of immersive environments in facilitating visitor interaction with collections. Drawing on art-based methodologies, the project proposes the use of artistic autoethnography and cultural probes to help understand the subjective encounter with archival material and gain insights into creative processes, in turn creating generous interfaces for the exhibition of digital archiving. The project proposes a model for digitizing the poster archive of Teatermuseet in Malmö, taking into account embodied interaction and embodied creativity and considerations of spatial, performative, and material design qualities, aiming to facilitate creative use of the material - in ways that allow for continuous iterations to happen as the material is exhibited

Hemlösas upplevelser av sin livs- och karriärutveckling

Studiens problemområde är att antalet hemlösa i Sverige ökar, vilket därmed utgör ett tydligt samhällsproblem och det kräver ansvarstagande. Hemlöshet är ett komplext faktum som uppkommer med arbetslöshet, ökade boendekostnader och försämringar i välfärdssystemet. Syftet med denna studie är att undersöka hemlösas upplevelser av sin livs- och karriärutveckling, detta för att få en ökad förståelse av gruppens upplevda möjligheter utifrån valda teorier och tidigare forskning. Studiens frågeställningar lyder: Hur blev dessa personer hemlösa? Hur ser de hemlösas pågående livssituation ut? Hur upplever de hemlösa sina karriärmöjligheter? Jag har valt att använda kvalitativa metoder i studien för att få svar på intervjufrågor. Jag har intervjuat sex hemlösa i Skåne län, i områdena kring Malmö och Lund. I arbetet använder jag mig av delar av Bourdieus teorier och Hodkinson och Sparkes Careershipteori. Bourdieus teorier kan delas in i tre huvudbegrepp: fält, kapital och habitus. Hodkinson och Sparkes karriärteori är baserad på sociologiska och psykologiska utgångspunkter utifrån teoretiska begrepp från Bourdieus teori om habitus, kapital och fält. Ett huvudresultat visar att informanter blev hemlösa på grund av att de gick igenom en brytpunkt i form av att de fick avsluta sina dåvarande arbeten. Det resulteras även att alkoholmissbruk och psykisk ohälsa i form av depression påverkade deras övergång till hemlöshet. Huvudresultatet visar även att hemlösas tankar om karriärmöjligheter som studier och arbete är relativt låg.Study's problem area is that the number of homeless people in Sweden growths, thereby constituting a distinct social problem and it requires responsibility. Homelessness is a complex fact caused by unemployment, rising housing costs and deterioration in the welfare system. The purpose of this study is to investigate the homeless experiences of his life and career development, in order to get a better understanding of the group's perceived opportunities from selected theories and previous research. The study's questions are: How did these people homeless? How do the homeless current life situation like? How do the homeless their career prospects? I have chosen to use qualitative methods in the study to get answers to interview questions. I have interviewed six homeless in Skåne, in the areas around Malmö and Lund. I use parts of Bourdieu's theories and Hodkinson and Sparkes Career Ship Theory. Bourdieu's theories can be separated into three main concepts: field, capital and habitus. Hodkinson and Sparkes Career Ship Theory is based on sociological and psychological starting points based on theoretical concepts from Bourdieu's theories of habitus, capital and field. The main results show that the informants became homeless because they went through a breaking point as they had quit their former jobs. It resulted also that alcohol abuse and mental illness in the form of depression affected their change to homelessness. The main result also shows that homeless thoughts about the career opportunities of study and work is relatively low

A Site(s)-Specific Digital Archive : Fostering Embodied and Creative Use of The Poster Archive at Teatermuseet in Malmö

This thesis project explores how interaction design can assist in preserving and making accessible the cultural heritage of theatre in Skåne, by collaborating with Teatermuseet in Malmö. The research seeks to answer how the collection of posters belonging to the museum can be made more accessible to a wider audience and how creativity can be used as an accelerator for designing immersive digital-tangible concepts for archiving. This is done by examining the evolving landscape of the sector of Galleries, Libraries, Archives and Museums, the challenges and opportunities presented by digital archiving, and the role of immersive environments in facilitating visitor interaction with collections. Drawing on art-based methodologies, the project proposes the use of artistic autoethnography and cultural probes to help understand the subjective encounter with archival material and gain insights into creative processes, in turn creating generous interfaces for the exhibition of digital archiving. The project proposes a model for digitizing the poster archive of Teatermuseet in Malmö, taking into account embodied interaction and embodied creativity and considerations of spatial, performative, and material design qualities, aiming to facilitate creative use of the material - in ways that allow for continuous iterations to happen as the material is exhibited

Depression, the Devil & Transformation : A semiotic analysis of the devil as a visual metaphor for depression in the animated short film How Have You Been?

Uppsatsens syfte är att analysera hur djävulsgestalten används som visuell metafor för depression i den animerade kortfilmen How Have You Been? (2020) skapad av Polly Nor och Adam Baker. Detta med målet att skapa bredare förståelse för hur visuella metaforer kan användas inom visuell kommunikation för att gestalta känslor. Studien utförs med hjälp av en semiotisk analys samt metaforanalys med teoretisk utgångspunkt i semiotik och metaforteori. Uppsatsen resulterade i kunskap kring hur den visuella metaforen förstärks genom personifiering av depression samt en stark relation mellan protagonist o antagonist. Även förvandling av djävulsgestalten har stor betydelse för hur den visuella metaforen tolkas. Ytterligare framkom det att filmskaparna använder symboler samt ickeverbal kommunikation för att förstärka den visuella metaforen. The purpose of this thesis is to analyze how the devil figure is used as a visual metaphor for depression in the animated short film How Have You Been? (2020) made by Polly Nor and Adam Baker. This with the goal to create a wider understanding about how visual metaphor can be used in the field of visual communication to portray emotions. The study is carried out with the help of a semiotic analysis as well as a metaphor analysis with a theoretical basis in semiotics and metaphor theory. The thesis resulted in knowledge about how the visual metaphor is enhanced through the personification of depression and a strong relationship between the protagonist and the antagonist. The transformation of the devil figure is also of great importance for how the visual metaphor is interpreted. Furthermore, it became clear that the filmmakers use symbols and non-verbal communication to enhance the visual metaphor.