Incremental planning to control a blackboard-based problem solver

To control problem solving activity, a planner must resolve uncertainty about which specific long-term goals (solutions) to pursue and about which sequences of actions will best achieve those goals. A planner is described that abstracts the problem solving state to recognize possible competing and compatible solutions and to roughly predict the importance and expense of developing these solutions. With this information, the planner plans sequences of problem solving activities that most efficiently resolve its uncertainty about which of the possible solutions to work toward. The planner only details actions for the near future because the results of these actions will influence how (and whether) a plan should be pursued. As problem solving proceeds, the planner adds new details to the plan incrementally, and monitors and repairs the plan to insure it achieves its goals whenever possible. Through experiments, researchers illustrate how these new mechanisms significantly improve problem solving decisions and reduce overall computation. They briefly discuss current research directions, including how these mechanisms can improve a problem solver's real-time response and can enhance cooperation in a distributed problem solving network

Automatic Detection of Seizures with Applications

There are an estimated two million people with epilepsy in the United States. Many of these people do not respond to anti-epileptic drug therapy. Two devices can be developed to assist in the treatment of epilepsy. The first is a microcomputer-based system designed to process massive amounts of electroencephalogram (EEG) data collected during long-term monitoring of patients for the purpose of diagnosing seizures, assessing the effectiveness of medical therapy, or selecting patients for epilepsy surgery. Such a device would select and display important EEG events. Currently many such events are missed. A second device could be implanted and would detect seizures and initiate therapy. Both of these devices require a reliable seizure detection algorithm. A new algorithm is described. It is believed to represent an improvement over existing seizure detection algorithms because better signal features were selected and better standardization methods were used

An extended view of the Pisces Overdensity from the SCUSS survey

SCUSS is a u-band photometric survey covering about 4000 square degree of the South Galactic Cap, reaching depths of up to 23 mag. By extending around 1.5 mag deeper than SDSS single-epoch u data, SCUSS is able to probe much a larger volume of the outer halo, i.e. with SCUSS data blue horizontal branch (BHB) stars can trace the outer halo of the Milky Way as far as 100-150 kpc. Utilizing this advantage we combine SCUSS u band with SDSS DR9 gri photometric bands to identify BHB stars and explore halo substructures. We confirm the existence of the Pisces overdensity, which is a structure in the outer halo (at around 80 kpc) that was discovered using RR Lyrae stars. For the first time we are able to determine its spatial extent, finding that it appears to be part of a stream with a clear distance gradient. The stream, which is ~5 degrees wide and stretches along ~25 degrees, consists of 20-30 BHBs with a total significance of around 6sigma over the background. Assuming we have detected the entire stream and that the progenitor has fully disrupted, then the number of BHBs suggests the original system was similar to smaller classical or a larger ultra-faint dwarf galaxy. On the other hand, if the progenitor still exists, it can be hunted for by reconstructing its orbit from the distance gradient of the stream. This new picture of the Pisces overdensity sheds new light on the origin of this intriguing system.Comment: 8 pages, 4 figures, accepted by Ap

A high throughput molecular force assay for protein-DNA interactions.

An accurate and genome-wide characterization of protein–DNA interactions such as transcription factor binding is of utmost importance for modern biology. Powerful screening methods emerged. But the vast majority of these techniques depend on special labels or markers against the ligand of interest and moreover most of them are not suitable for detecting low-affinity binders. In this article a molecular force assay is described based on measuring comparative unbinding forces of biomolecules for the detection of protein–DNA interactions. The measurement of binding or unbinding forces has several unique advantages in biological applications since the interaction between certain molecules and not the mere presence of one of them is detected. No label or marker against the protein is needed and only specifically bound ligands are detected. In addition the force-based assay permits the detection of ligands over a broad range of affinities in a crowded and opaque ambient environment. We demonstrate that the molecular force assay allows highly sensitive and fast detection of protein–DNA interactions. As a proof of principle, binding of the protein EcoRI to its DNA recognition sequence is measured and the corresponding dissociation constant in the sub-nanomolar range is determined. Furthermore, we introduce a new, simplified setup employing FRET pairs on the molecular level and standard epi-fluorescence for readout. Due to these advancements we can now demonstrate that a feature size of a few microns is sufficient for the measurement process. This will open a new paradigm in high-throughput screening with all the advantages of force-based ligand detection. Graphical abstract: A high throughput molecular force assay for protein–DNA interaction

Emerging communities of child-healthcare practice in the management of long-term conditions such as chronic kidney disease: Qualitative study of parents' accounts

Background: Parents of children and young people with long-term conditions who need to deliver clinical care to their child at home with remote support from hospital-based professionals, often search the internet for care-giving information. However, there is little evidence that the information available online was developed and evaluated with parents or that it acknowledges the communities of practice that exist as parents and healthcare professionals share responsibility for condition management. Methods. The data reported here are part of a wider study that developed and tested a condition-specific, online parent information and support application with children and young people with chronic-kidney disease, parents and professionals. Semi-structured interviews were conducted with 19 fathers and 24 mothers who had recently tested the novel application. Data were analysed using Framework Analysis and the Communities of Practice concept. Results: Evolving communities of child-healthcare practice were identified comprising three components and several sub components: (1) Experiencing (parents making sense of clinical tasks) through Normalising care, Normalising illness, Acceptance & action, Gaining strength from the affected child and Building relationships to formalise a routine; (2) Doing (Parents executing tasks according to their individual skills) illustrated by Developing coping strategies, Importance of parents' efficacy of care and Fear of the child's health failing; and (3) Belonging/Becoming (Parents defining task and group members' worth and creating a personal identity within the community) consisting of Information sharing, Negotiation with health professionals and Achieving expertise in care. Parents also recalled factors affecting the development of their respective communities of healthcare practice; these included Service transition, Poor parent social life, Psycho-social affects, Family chronic illness, Difficulty in learning new procedures, Shielding and avoidance, and Language and cultural barriers. Health care professionals will benefit from using the communities of child-healthcare practice model when they support parents of children with chronic kidney disease. Conclusions: Understanding some of the factors that may influence the development of communities of child-healthcare practice will help professionals to tailor information and support for parents learning to manage their child's healthcare. Our results are potentially transferrable to professionals managing the care of children and young people with other long-term conditions. © 2014 Carolan et al.; licensee BioMed Central Ltd

Discovery of Globular Clusters in the Proto-Spiral NGC2915: Implications for Hierarchical Galaxy Evolution

We have discovered three globular clusters beyond the Holmberg radius in Hubble Space Telescope Advanced Camera for Surveys images of the gas-rich dark matter dominated blue compact dwarf galaxy NGC2915. The clusters, all of which start to resolve into stars, have M_{V606} = -8.9 to -9.8 mag, significantly brighter than the peak of the luminosity function of Milky Way globular clusters. Their colors suggest a metallicity [Fe/H] ~ -1.9 dex, typical of metal-poor Galactic globular clusters. The specific frequency of clusters is at a minimum normal, compared to spiral galaxies. However, since only a small portion of the system has been surveyed it is more likely that the luminosity and mass normalized cluster content is higher, like that seen in elliptical galaxies and galaxy clusters. This suggests that NGC2915 resembles a key phase in the early hierarchical assembly of galaxies - the epoch when much of the old stellar population has formed, but little of the stellar disk. Depending on the subsequent interaction history, such systems could go on to build-up larger elliptical galaxies, evolve into normal spirals, or in rare circumstances remain suspended in their development to become systems like NGC2915.Comment: ApJ Letters accepted; 6 pages, 2 figures, 3 table

The Luminosity Function of Early-Type Galaxies at z~0.75

We measure the luminosity function of morphologically selected E/S0 galaxies from $z=0.5$ to $z=1.0$ using deep high resolution Advanced Camera for Surveys imaging data. Our analysis covers an area of 48\Box\arcmin (8$\times$ the area of the HDF-N) and extends 2 magnitudes deeper ($I\sim24$ mag) than was possible in the Deep Groth Strip Survey (DGSS). At $0.5<z<0.75$, we find $M_B^*-5\log h_{0.7}=-21.1\pm0.3$ and $\alpha=-0.53\pm0.2$, and at $0.75<z<1.0$, we find $M_B^*-5\log h_{0.7}=-21.4\pm0.2$. These luminosity functions are similar in both shape and number density to the luminosity function using morphological selection (e.g., DGSS), but are much steeper than the luminosity functions of samples selected using morphological proxies like the color or spectral energy distribution (e.g., CFRS, CADIS, or COMBO-17). The difference is due to the `blue', $(U-V)_0<1.7$, E/S0 galaxies, which make up to $\sim30$ of the sample at all magnitudes and an increasing proportion of faint galaxies. We thereby demonstrate the need for {\it both morphological and structural information} to constrain the evolution of galaxies. We find that the `blue' E/S0 galaxies have the same average sizes and Sersic parameters as the `red', $(U-V)_0>1.7$, E/S0 galaxies at brighter luminosities ($M_B<-20.1$), but are increasingly different at fainter magnitudes where `blue' galaxies are both smaller and have lower Sersic parameters. Fits of the colors to stellar population models suggest that most E/S0 galaxies have short star-formation time scales ($\tau<1$ Gyr), and that galaxies have formed at an increasing rate from $z\sim8$ until $z\sim2$ after which there has been a gradual decline.Comment: 39 pages, 21 figures, accepted in A

Advanced Camera for Surveys Observations of Young Star Clusters in the Interacting Galaxy UGC 10214

We present the first Advanced Camera for Surveys (ACS) observations of young star clusters in the colliding/merging galaxy UGC 10214. The observations were made as part of the Early Release Observation (ERO) program for the newly installed ACS during service mission SM3B for the Hubble Space Telescope (HST). Many young star clusters can be identified in the tails of UGC 10214, with ages ranging from ~3 Myr to 10 Myr. The extreme blue V-I (F606W-F814W) colors of the star clusters found in the tail of UGC 10214 can only be explained if strong emission lines are included with a young stellar population. This has been confirmed by our Keck spectroscopy of some of these bright blue stellar knots. The most luminous and largest of these blue knots has an absolute magnitude of M_V = -14.45, with a half-light radius of 161 pc, and if it is a single star cluster, would qualify as a super star cluster (SSC). Alternatively, it could be a superposition of multiple scaled OB associations or clusters. With an estimated age of ~ 4-5 Myr, its derived mass is < 1.3 x 10^6 solar masses. Thus the young stellar knot is unbound and will not evolve into a normal globular cluster. The bright blue clusters and associations are much younger than the dynamical age of the tail, providing strong evidence that star formation occurs in the tail long after it was ejected. UGC 10214 provides a nearby example of processes that contributed to the formation of halos and intra-cluster media in the distant and younger Universe.Comment: 6 pages with embedded figures, ApJ in pres

Internal Color Properties of Resolved Spheroids in the Deep HST/ACS field of UGC 10214

(Abridged) We study the internal color properties of a morphologically selected sample of spheroidal galaxies taken from HST/ACS ERO program of UGC 10214 (``The Tadpole''). By taking advantage of the unprecedented high resolution of the ACS in this very deep dataset we are able to characterize spheroids at sub-arcseconds scales. Using the V_606W and I_814W bands, we construct V-I color maps and extract color gradients for a sample of spheroids at I_814W < 24 mag. We investigate the existence of a population of morphologically classified spheroids which show extreme variation in their internal color properties similar to the ones reported in the HDFs. These are displayed as blue cores and inverse color gradients with respect to those accounted from metallicity variations. Following the same analysis we find a similar fraction of early-type systems (~30%-40%) that show non-homologous internal colors, suggestive of recent star formation activity. We present two statistics to quantify the internal color variation in galaxies and for tracing blue cores, from which we estimate the fraction of non-homogeneous to homogeneous internal colors as a function of redshift up to z<1.2. We find that it can be described as about constant as a function of redshift, with a small increase with redshift for the fraction of spheroids that present strong color dispersions. The implications of a constant fraction at all redshifts suggests the existence of a relatively permanent population of evolving spheroids up to z~1. We discuss the implications of this in the context of spheroidal formation.Comment: Fixed URL for high resolution version. 13 Pages, 10 Figures. Accepted for Publication in ApJ. Sep 1st issue. Higher resolution version and complete table3B at http://acs.pha.jhu.edu/~felipe/e-prints/Tadpol