Dark matter allowed scenarios for Yukawa-unified SO(10) SUSY GUTs

Simple supersymmetric grand unified models based on the gauge group SO(10) require --in addition to gauge and matter unification-- the unification of t-b-\tau Yukawa couplings. Yukawa unification, however, only occurs for very special values of the soft SUSY breaking parameters. We perform a search using a Markov Chain Monte Carlo (MCMC) technique to investigate model parameters and sparticle mass spectra which occur in Yukawa-unified SUSY models, where we also require the relic density of neutralino dark matter to saturate the WMAP-measured abundance. We find the spectrum is characterizd by three mass scales: first/second generation scalars in the multi-TeV range, third generation scalars in the TeV range, and gauginos in the \sim 100 GeV range. Most solutions give far too high a relic abundance of neutralino dark matter. The dark matter discrepancy can be rectified by 1. allowing for neutralino decay to axino plus photon, 2. imposing gaugino mass non-universality or 3. imposing generational non-universality. In addition, the MCMC approach finds 4. a compromise solution where scalar masses are not too heavy, and where neutralino annihilation occurs via the light Higgs h resonance. By imposing weak scale Higgs soft term boundary conditions, we are also able to generate 5. low \mu, m_A solutions with neutralino annihilation via a light A resonance, though these solutions seem to be excluded by CDF/D0 measurements of the B_s\to \mu^+\mu^- branching fraction. Based on the dual requirements of Yukawa coupling unification and dark matter relic density, we predict new physics signals at the LHC from pair production of 350--450 GeV gluinos. The events are characterized by very high b-jet multiplicity and a dilepton mass edge around mz2-mz1 \sim 50-75 GeV.Comment: 35 pages with 21 eps figure

A critical review of the formation of mono- and dicarboxylated metabolic intermediates of alkylphenol polyethoxylates during wastewater treatment and their environmental significance

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 Taylor & Francis.Alkylphenoxyacetic acids, the metabolic biodegradation products of alkylphenol ethoxylates, are commonly found in wastewaters and sewage effluents. These persistent hydrophilic derivatives possess intrinsic estrogenic activity, which can mimic natural hormones. Their concentrations increase through the sewage treatment works as a result of biodegradation and biotransformation, and when discharged can disrupt endocrine function in fish. These acidic metabolites represent the dominant alkylphenolic compounds found in wastewater effluent and their presence is cause for concern as, potentially, through further biotransformation and biodegradation, they can act as sources of nonylphenol, which is toxic and estrogenic. The authors aim to assess the mechanisms of formation as well as elimination of alkylphenoxyacetic acids within conventional sewage treatment works with the emphasis on the activated sludge process. In addition, they evaluate the various factors influencing their degradation and formation in laboratory scale and full-scale systems. The environmental implications of these compounds are considered, as is the need for tertiary treatment processes for their removal

Mixed Higgsino Dark Matter from a Reduced SU(3) Gaugino Mass: Consequences for Dark Matter and Collider Searches

In gravity-mediated SUSY breaking models with non-universal gaugino masses, lowering the SU(3) gaugino mass |M_3| leads to a reduction in the squark and gluino masses. Lower third generation squark masses, in turn, diminish the effect of a large top quark Yukawa coupling in the running of the higgs mass parameter m_{H_u}^2, leading to a reduction in the magnitude of the superpotential mu parameter (relative to M_1 and M_2). A low | mu | parameter gives rise to mixed higgsino dark matter (MHDM), which can efficiently annihilate in the early universe to give a dark matter relic density in accord with WMAP measurements. We explore the phenomenology of the low |M_3| scenario, and find for the case of MHDM increased rates for direct and indirect detection of neutralino dark matter relative to the mSUGRA model. The sparticle mass spectrum is characterized by relatively light gluinos, frequently with m(gl)<<m(sq). If scalar masses are large, then gluinos can be very light, with gl->Z_i+g loop decays dominating the gluino branching fraction. Top squarks can be much lighter than sbottom and first/second generation squarks. The presence of low mass higgsino-like charginos and neutralinos is expected at the CERN LHC. The small m(Z2)-m(Z1) mass gap should give rise to a visible opposite-sign/same flavor dilepton mass edge. At a TeV scale linear e^+e^- collider, the region of MHDM will mean that the entire spectrum of charginos and neutralinos are amongst the lightest sparticles, and are most likely to be produced at observable rates, allowing for a complete reconstruction of the gaugino-higgsino sector.Comment: 35 pages, including 26 EPS figure

Using fractional exhaled nitric oxide (FeNO) to diagnose steroid-responsive disease and guide asthma management in routine care

Acknowledgements We thank Robin Taylor for his informative thinking and publications on FeNO, which have helped to influence and direct the thinking of the authors. Funding Extraction of the real-life dataset was funded by Research in Real Life Limited, the analysis of the dataset and the writing of this manuscript were co-funded (50:50) by Research in Real Life Limited and Aerocrine.Peer reviewedPublisher PD

Treating tobacco dependence in older adults: a survey of primary care clinicians’ knowledge, attitudes, and practice

BACKGROUND: The benefits of smoking cessation among older people are well documented. Despite this, evidence suggests that older smokers are rarely engaged in smoking cessation efforts, and that existing tobacco dependence treatments require further tailoring to the specific needs of older smokers. This study assesses the knowledge, attitudes, and clinical practice of primary care clinicians in relation to addressing tobacco dependence among older people. METHODS: A cross-sectional survey of 427 NHS primary care clinicians in a large English city was conducted using modified version of a previously validated questionnaire. RESULTS: One hundred and seventy one clinicians (40 % response rate) completed the survey. While the majority (90.0 %) of respondents reported enquiring regularly about older patients’ smoking status, just over half (59.1 %) reported providing older patients with smoking cessation support. A lack of awareness in relation to the prevalence and impact of smoking in later life were apparent: e.g. only 47 % of respondents were aware of that approximately 10 life years are lost due to smoking related disease, and only 59 % knew that smoking can reduce the effectiveness of medication prescribed for conditions common in later life. Self-reported attendance at smoking-related training was significantly associated with proactive clinical practice. CONCLUSIONS: There is a need to improve clinicians’ knowledge, in relation to smoking and smoking cessation in older patients and to build clinician confidence in seizing teachable moments. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12875-015-0317-7) contains supplementary material, which is available to authorized users

Children's play space and safety management: rethinking the role of play equipment standards

The provision of stimulating and engaging play space for children and young people is increasingly recognized as an important societal goal, not the least because it provides the young with opportunities to develop and gain experience in experimenting with risk. Research in several disciplines now suggests that achievement of this goal has however been impeded in recent decades, and reasons commonly cited have included fear of injury and avoidance of litigation. International standards on play equipment have also been promulgated and justified in terms of securing young people’s “safety,” most usually narrowly defined as injury reduction. There appears to be a widespread presumption that measures aimed at injury prevention are necessarily beneficial overall for young people’s welfare. In this article, we subject European standards for play equipment and surfacing to scrutiny. In particular, we examine underlying motives, consistency of purpose, use of evidence, philosophical leanings, scope, practicalities of application, systems of management, and legal ramifications. From this, we identify a number of fundamental issues that suggest that as a consequence of compartmentalized thinking and misunderstandings, these standards have invaded areas of decision making beyond their legitimate territory. The consequence of this is that play provision is skewed away from what are properly play provision objectives. In such circumstances, local decision makers are often disempowered, and their ability to provide optimal play spaces thereby circumscribed

Computer-based technology and student engagement: a critical review of the literature

Computer-based technology has infiltrated many aspects of life and industry, yet there is little understanding of how it can be used to promote student engagement, a concept receiving strong attention in higher education due to its association with a number of positive academic outcomes. The purpose of this article is to present a critical review of the literature from the past 5 years related to how web-conferencing software, blogs, wikis, social networking sites (Facebook and Twitter), and digital games influence student engagement. We prefaced the findings with a substantive overview of student engagement definitions and indicators, which revealed three types of engagement (behavioral, emotional, and cognitive) that informed how we classified articles. Our findings suggest that digital games provide the most far-reaching influence across different types of student engagement, followed by web-conferencing and Facebook. Findings regarding wikis, blogs, and Twitter are less conclusive and significantly limited in number of studies conducted within the past 5 years. Overall, the findings provide preliminary support that computer-based technology influences student engagement, however, additional research is needed to confirm and build on these findings. We conclude the article by providing a list of recommendations for practice, with the intent of increasing understanding of how computer-based technology may be purposefully implemented to achieve the greatest gains in student engagement. © 2017, The Author(s)

Framework and indicator testing protocol for developing and piloting quality indicators for the UK quality and outcomes framework

Contains fulltext : 96936.pdf (publisher's version ) (Open Access)BACKGROUND: Quality measures should be subjected to a testing protocol before being used in practice using key attributes such as acceptability, feasibility and reliability, as well as identifying issues derived from actual implementation and unintended consequences. We describe the methodologies and results of an indicator testing protocol (ITP) using data from proposed quality indicators for the United Kingdom Quality and Outcomes Framework (QOF). METHODS: The indicator testing protocol involved a multi-step and methodological process: 1) The RAND/UCLA Appropriateness Method, to test clarity and necessity, 2) data extraction from patients' medical records, to test technical feasibility and reliability, 3) diaries, to test workload, 4) cost-effectiveness modelling, and 5) semi-structured interviews, to test acceptability, implementation issues and unintended consequences. Testing was conducted in a sample of representative family practices in England. These methods were combined into an overall recommendation for each tested indicator. RESULTS: Using an indicator testing protocol as part of piloting was seen as a valuable way of testing potential indicators in 'real world' settings. Pilot 1 (October 2009-March 2010) involved thirteen indicators across six clinical domains and twelve indicators passed the indicator testing protocol. However, the indicator testing protocol identified a number of implementation issues and unintended consequences that can be rectified or removed prior to national roll out. A palliative care indicator is used as an exemplar of the value of piloting using a multiple attribute indicator testing protocol - while technically feasible and reliable, it was unacceptable to practice staff and raised concerns about potentially causing actual patient harm. CONCLUSIONS: This indicator testing protocol is one example of a protocol that may be useful in assessing potential quality indicators when adapted to specific country health care settings and may be of use to policy-makers and researchers worldwide to test the likely effect of implementing indicators prior to roll out. It builds on and codifies existing literature and other testing protocols to create a field testing methodology that can be used to produce country specific quality indicators for pay-for-performance or quality improvement schemes

The Law of Society: Governance Through Contract

This paper focuses on contract law as a central field in contemporary regulatory practice. In recent years, governance by contract has emerged as the central concept in the context of domestic privatization, domestic and transnational commercial relations and law-and-development projects. Meanwhile, as a result of the neo-formalist attack on contract law, governance of contract through contract adjudication, consumer protection law and judicial intervention into private law relations has come under severe pressure. Building on early historical critique of the formalist foundations of an allegedly private law of the market, the paper assesses the current justifications for contractual governance and posits that only an expanded legal realist perspective can adequately explain the complex nature of contractual agreements in contemporary practice. The paper argues for an understanding of contracts as complex societal arrangements that visibilize and negotiate conflicting rationalities and interests. Institutionally, contractual governance has been unfolding in a complex, historically grown and ideologically continually contested regulatory field. Governance through contract, then, denotes a wide field of conflicting concepts, ideas and symbols, that are themselves deeply entrenched in theories of society, market and the state. From this perspective, we are well advised to study contracts in their socio-economic, historical and cultural context. A careful reading of scholars such as Henry Sumner Maine, Morris Cohen, Robert Hale, Karl Llewellyn, Stewart Macaulay and Ian Macneil offers a deeper understanding of the institutional and normative dimensions of contractual governance. Their analysis is particularly helpful in assessing currently ongoing shifts away from a welfare state based regulation (governance) of contractual relations. Such shifts are occurring on two levels. First, they take place against the backdrop of a neo-liberal critique of government interference into allegedly private relations. Secondly, the increasingly influential return to formalism in contract law, which privileges a functionalist, purportedly technical and autonomous design and execution of contractual agreements over the view of regulated contracts, is linked to a particular concept of sovereignty. The ensuing revival of freedom of contract occurs in remarkable neglect of the experiences of welfare state adjudication of private law adjudication and a continuing contestation of the political in private relationships. The paper takes up the Legal Realists\u27 search for the \u27basis of contract\u27, but seeks to redirect the focus from the traditional perspective on state vs. market to a disembedded understanding of contractual governance as delineating multipolar and multirational regulatory regimes. Where Globalization has led to a fragmentation, disembeddedness and transnationalization of contexts and, thus, has been challenging traditional understanding of embeddedness, the task should no longer be to try applying a largely nation-state oriented Legal Realist perspective and critique to the sphere of contemporary contractual governance, but - rather - to translate its aims into a more reflexive set of instruments of legal critique. Even if Globalization has led to a dramatic denationalization of many regulatory fields and functions, it is still not clear, whether and how Globalization replaces, complements or aggravates transformations of societal governance, with and through contract