The child as held in the mind of the mother: The influence of prenatal maternal representations on parenting behaviors

Using a longitudinal design, this study examined the relationship of a mother’s prenatal representation of her child and her parenting behavior with that child at one-year-of-age in a sample of women who were either exposed or not exposed to intimate partner violence (IPV) (n = 164; mean child age = 1.1 years, sd = .11 years; 52% male). Controlling for prenatal IPV, a MANCOVA analysis revealed that prenatal representational typology was significantly related to parenting behavior one year post-partum. Mothers whose representations were affectively deactivated (disengaged) were more behaviorally controlling with their children. Mothers whose representations were affectively overactivated (distorted) were more hostile with their children. Mothers with balanced representations demonstrated more positive parenting. Exposure to IPV did not moderate this relationship. There was no direct association between pre-natal or post-natal IPV and parenting behavior. These findings suggest that prenatal representations influence postnatal parenting behavior in significant and theoretically consistent ways and that this relationship functions similarly for both abused and non-abused women. Results add to the growing literature that internal representations serve to guide behavior throughout development and suggest that maternal working models may be one important link in the intergenerational transmission of attachment relationships

Physiological Response of Elasmobrachs During Propofol Immersion

Sensory experiments require anesthesia so the animal is immobilized, however fish anesthetics have shown to depress sensory responses. Newer anesthetics may offer similar anesthetic relief, but differ in means of action so sensory responses may be unaffected. Propofol has been used intravenously on small elasmobranchs but may provide prolonged effects if used as an immersion anesthetic. Objectives of this study were 1. Determine appropriate concentration of anesthetic to minimize induction and recovery for animals anesthetized at a surgical plane of anesthesia and 2. Measure physiological response of the pupil to light stimuli during anesthetic immersion. To address these objectives, I used the coral catshark (Atelomycterus marmoratus) and the Atlantic stingray (Hypanus sabinus). Ventilation rate and reflex responses were recorded to measure induction and recovery in increasing concentrations of tricaine and propofol. Appropriate concentrations of anesthetics are approximately 160 and 1.4, and 140 and 0.7 mg L-1of tricaine and propofol in A. marmoratus and H. sabinus, respectively. After 1.5 hours of dark adaptation in anesthetic (50, 100, or 150 mg L-1 tricaine or 0.5, 1, or 1.5 mg L-1 propofol) or no anesthesia (control), tricaine 100 mg L-1 trials show reduction in percent pupil constriction (p-1 trials in Atlantic stingrays (p-1 of propofol (p anesthetized using 1.5 mg L-1of propofol (

Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids

Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To advance informed vaccine design, it is critical that we understand the cellular dynamics underlying responses to different antigen formats. Here, we sought to understand how antigen-specific B and T cells were activated and participated in adaptive immune responses within the mucosal site. Using a human tonsil organoid model, we tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities. Each antigen format elicited distinct B and T cell responses, including differences in their magnitude, diversity, phenotype, function, and breadth. These differences culminated in substantial changes in the corresponding antibody response. A major source of antigen format-related variability was the ability to recruit naive vs. memory B and T cells to the response. These findings have important implications for vaccine design and the generation of protective immune responses in the upper respiratory tract

Introduction to the Special Section on Complex Posttraumatic Stress Disorder (CPTSD): The Evolution of a Disorder

The inclusion of complex posttraumatic stress disorder (CPTSD) in the 11th revision of the International Classification of Diseases is an important development in the field of psychotraumatology. Complex PTSD was developed as a response to a clinical need to describe difficulties commonly associated with exposure to traumatic stressors that are predominantly of an interpersonal nature. With this special section, we bring attention to this common condition following exposure to traumatic stressors that only recently has been designated an official diagnosis. In this introduction, we review the history of CPTSD as a new condition and we briefly introduce the papers for the special section in the present issue of the Journal of Traumatic Stress. It is our hope that the work presented in the special section will add to an ever?expanding evidence base. We also hope that this work inspires further research on the cultural validity of CPTSD, its assessment, and treatment

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

This work was funded by Wellcome Senior Fellowship 095062, Wellcome Trust grants 094090, 099149 and 097945. ALH was funded by an EMBO long term fellowship ALTF 380–2015 co-funded by the European Commission (LTFCOFUND2013, GA-2013–609409).ATP-dependent chromatin remodelling proteins represent a diverse family of proteins that share ATPase domains that are adapted to regulate protein-DNA interactions. Here, we present structures of the Saccharomyces cerevisiae Chd1 protein engaged with nucleosomes in the presence of the transition state mimic ADP-beryllium fluoride. The path of DNA strands through the ATPase domains indicates the presence of contacts conserved with single strand translocases and additional contacts with both strands that are unique to Snf2 related proteins. The structure provides connectivity between rearrangement of ATPase lobes to a closed, nucleotide bound state and the sensing of linker DNA. Two turns of linker DNA are prised off the surface of the histone octamer as a result of Chd1 binding, and both the histone H3 tail and ubiquitin conjugated to lysine 120 are re-orientated towards the unravelled DNA. This indicates how changes to nucleosome structure can alter the way in which histone epitopes are presented.Publisher PDFPeer reviewe

The impact of psychopathology associated with childhood trauma on quality of life in Portuguese adolescents: a two-wave longitudinal study

Introduction: The aim of this study was to explore the mediating effect of psychopathology between childhood adversity and trauma and quality of life (QOL) in adolescents. The second aim of the study was testing the moderation by social support of this mediation effect.Methods: Self-reports of childhood adversity and trauma, QOL, social support, and psychopathology were collected from 150 Portuguese adolescents' who had been exposed to at least one traumatic event or one childhood adversity (M-age = 16.89, SD = 1.32). The surveys were administered at two time points with an approximate time interval of 1 year.Results: Indirect effects were observed for depression (B = -0.33, CI [-0.62, -0.11]), somatization (B = -0.52, CI [-0.82, -0.23]), and post-traumatic stress symptoms (PTSS) (B = -0.23, CI [-0.45, -0.01]), but not for anxiety (B = 0.20, CI [-0.08, 0.50]). A moderated mediation was found between social support and depression (B = -0.10, CI [-16, -0.04]), and PTSS (B = 0.03, CI [-0.1, -0.05]), but not for somatization (B = -0.02, CI [-0.8, 0.05]).Conclusions: We found that depression and somatization were strong mediators of the relationship between adversity/trauma and QOL, whereas PTSS was moderately mediated this relationship. Anxiety did not mediate this relationship. The moderated-mediation effect of social support was only found for depression and PTSS. The improvement of QOL in adolescents exposed to childhood adversity and trauma should include the assessment of psychopathology symptoms and social support, with the aim of identifying risk and protective factors.- (undefined

Child's Play? Children and Young People's Resistances to Domestic Violence and Abuse

Children and young people's (CYP) space to play can be constrained in families affected by domestic violence and abuse (DVA), potentially impacting their development. Play also has the potential to strengthen CYP's capacity to resist controlling and abusive dynamics in the family. Interviews were conducted with 107 CYP aged 8–18, and were analysed using interpretive interactionism. Three themes relevant to children's experiences of play were identified: Play and Coercive Control; Play Re‐makes the World and Play and Relationality. This article highlights the potential for play to enable children to retain a sense of relational connectedness and agency, despite violence and control; we argue for more opportunities for children to play away from the gaze of adults and advocate for more dedicated services for families who experience DVA

Intimate Partner Violence, Mental Health, and HPA Axis Functioning

Research results are mixed as to whether stress exerts its damaging effects via under- or over-production of diurnal cortisol. Facets of the stressor itself as well as the mental health sequelae that follow have been put forward as important considerations in determining levels of cortisol secretion. We hypothesized that the contradictory findings in the literature were the result of variable-oriented methods masking the presence of distinctive subgroups of individuals. Using person-oriented methods, we explored whether there were classes of women who exhibited unique profiles of cortisol secretion, stress, and mental health by assessing 182 community women, many of whom had experienced intimate partner violence. The best fitting model in a latent profile analysis had 5 groups, each with distinct profiles of intimate partner violence stress (pregnancy and postpartum), cortisol secretion [cortisol awakening response (CAR) and diurnal slope], and mental health (posttraumatic stress, depressive, and anxiety symptoms). These were a Physiologically Under-Responsive group, a Healthy group, a Problematic CAR group, a Highest Stress/Normal Diurnal Slope group, and a Moderate Psychopathology/Normal Diurnal Slope group. Except for the Healthy group, the specific patterns of stress, mental health symptoms, and cortisol secretion identified in the literature were not found. The profiles were validated using variables that, in prior research, had shown relationships with the variables used to constitute the profiles—three types of parenting (neglectful, sensitive, and harsh), antisocial behavior, and physical health. We concluded that there is heterogeneity in women’s responses to stress. Current theories focused on the under- or over-production of diurnal cortisol in relation to stress and mental health symptoms are simplistic and fail to account for the significant subgroups of women who show unique biological and psychological responses. best free football betting tips uk oddslot latest football accumulator predictions u