Characterization of the complications associated with plasma exchange for thrombotic thrombocytopaenic purpura and related thrombotic microangiopathic anaemias: a single institution experience.

Plasma exchange (PEX) is a life-saving therapeutic procedure in patients with thrombotic thrombocytopaenic purpura (TTP) and other thrombotic microangiopathic anaemias (TMAs). However, it may be associated with significant complications, exacerbating the morbidity and mortality in this patient group

EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013 . Scientific opinion on Dietary Reference Values for fluoride

Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for fluoride, which are provided as Adequate Intake (AI) from all sources, including non-dietary sources. Fluoride is not an essential nutrient. Therefore, no Average Requirement for the performance of essential physiological functions can be defined. Nevertheless, the Panel considered that the setting of an AI is appropriate because of the beneficial effects of dietary fluoride on prevention of dental caries. The AI is based on epidemiological studies (performed before the 1970s) showing an inverse relationship between the fluoride concentration of water and caries prevalence. As the basis for defining the AI, estimates of mean fluoride intakes of children via diet and drinking water with fluoride concentrations at which the caries preventive effect approached its maximum whilst the risk of dental fluorosis approached its minimum were chosen. Except for one confirmatory longitudinal study in US children, more recent studies were not taken into account as they did not provide information on total dietary fluoride intake, were potentially confounded by the use of fluoride-containing dental hygiene products, and did not permit a conclusion to be drawn on a dose-response relationship between fluoride intake and caries risk. The AI of fluoride from all sources (including non-dietary sources) is 0.05 mg/kg body weight per day for both children and adults, including pregnant and lactating women. For pregnant and lactating women, the AI is based on the body weight before pregnancy and lactation. Reliable and representative data on the total fluoride intake of the European population are not available

Using a Contextual Effects Measurement Approach to Understand the Influence of Community on Individual Behavior

A social organization perspective identifies processes operating in the community that may influence an individual’s behavior. To understand such processes, researchers can apply a contextual effects measurement approach, which is used to assess the influence of group-level effects on lower level outcomes. However, few community studies employ this approach. The purpose of this article is to present and evaluate the merits of the contextual effects measurement approach

Cyber Insurance: recent advances, good practices & challenges

The aim of this ENISA report is to raise awareness for the most impact to market advances, by shortly identifying the most significant cyber insurance developments for the past four years – during 2012 to 2016 – and to capture the good practices and challenges during the early stages of the cyber insurance lifecycle, i.e. before an actual policy is signed, laying the ground for future work in the area

An analysis of the structure of Saturn's magnetic field using charged particle absorption signatures

A new technique is derived for determining the structure of Saturn's magnetic field. This technique uses the observed positions of charged particle absorption signatures due to the satellites and rings of Saturn to determine the parameters of an axially symmetric, spherical harmonic model of the magnetic field using the method of least squares. Absorption signatures observed along the Pioneer 11, Voyager 1, and Voyager 2 spacecraft trajectories are used to derive values for the orientation of the magnetic symmetry axis relative to Saturn's axis of rotation, the axial displacement of the center of the magnetic dipole from the center of Saturn, and the magnitude of the external field component. Comparing these results with the magnetic field model parameters deduced from analyses of magnetometer data leads us to prefer models that incorporate a northward offset of the dipole center by about 0.05 R_s

Compassionate pedagogy: the ethics of care in early childhood professionalism

This paper builds upon an earlier attempt (Taggart, 2011) to articulate a rationale for professional training in early childhood education and care (ECEC) which is ethical as opposed to one which is purely instrumental or rooted in a patriarchal notion of women’s supposed unique suitability. The argument proposes that a feminist approach to ethics, as both socially critical and psychologically affective or flexible, has a particular relevance to professional identity in ECEC. In particular, compassion, as a concept which has both sociological and psychological connotations, foregrounds the ethical dimension of the work whilst overcoming false dichotomies between discourses of ‘children’s rights’ and ‘care’. The implications for the training and professional identity of practitioners are discussed

Plasma exchange for COVID-19 thrombo-inflammatory disease.

Severe COVID-19 disease is a hyperinflammatory, pro-thrombotic state. We undertook plasma exchange (PEX) to determine its effects on organ function and thrombo-inflammatory markers. Seven critically ill adults with severe COVID-19 respiratory failure (PaO2:FiO2 ratio 800 IU/L and D-dimer >1000 μg/L (or doubling from baseline) received PEX, daily, for a minimum of 5 days. No other immunomodulatory medications were initiated during this period. Seven patients matched for age and baseline biochemistry were a comparator group. Coagulation screening revealed no evidence of coagulopathy. However, von Willebrand Factor (VWF) activity, antigen and VWF antigen: ADAMTS13 ratio, Factor VIII and D-dimers were all elevated. Following 5 days of PEX, plasma levels of all the above, and ferritin levels, were significantly reduced (P < .05) while lymphocyte counts normalized (P < .05). The PaO2:FiO2 ratio increased from a median interquartile range (IQR) of 11.6 (10.8-19.7) kPa to 18.1 (16.0-25.9) kPa (P < .05). Similar improvements were not observed in controls. Acute kidney injury (AKI) occurred among five patients in the control arm but not in patients receiving PEX. PEX improved oxygenation, decreased the incidence of AKI, normalized lymphocyte counts and reduced circulating thrombo-inflammatory markers including D-Dimer and VWF Ag:ADAMTS13 ratio

Registration of six disease resistant, high protein, induced allotetraploids derived from Arachis duranensis and A. ipaënsis, the genome progenitors of peanut.

The allotetraploid legume peanut (Arachis hypogaea L.) has low genetic diversity due to the single origin and ploidy barrier with its wild relatives, which are mostly diploid. This lack of genetic diversity hinders breeding and genetic gains. Wild peanut relatives harbor known resistances to pests and diseases and genetic variation that can contribute to adaptation to diverse environments and a changing climate. The ploidy barrier between the wild relatives and the cultigen can be surpassed by the production of induced allotetraploids using parents with genomes that are compatible to those of peanut. Here, we crossed seven accessions of six Arachis species. All combinations carried at least one of the peanut progenitors, A. ipaënsis and A. duranensis, crossed with a species of complementary genome. The original hybrids were treated with colchicine for recovery of fertility, observed by pollen viability and seed production. Six new allotetraploids were produced; they were named WPL-BatDur1 (Reg. no. GP-248, PI 707934), WPL-BatDur2 (Reg. no. GP-249, PI 707936), WPL-MagDur1 (Reg. no. GP-253, PI 707942), WPL-IpaCor1 (Reg. no. GP-251, PI 707938), WPL-IpaDur1 (Reg. no. GP-250, PI 707937), and WPL-IpaVillo1 (Reg. no. GP-252, PI 707941), released by the University of Georgia. Cytogenetic analyses confirmed the tetraploid plants had 20 A-type and 20 B- or K-type chromosomes. All these allotetraploids have surprisingly high protein content. They also show moderate to strong resistance to the main peanut fungal diseases (late and early leaf spot and rust) and Southern stem rot, are compatible with cultivated peanut, and are being used in breeding programs in the United States, Senegal, and Brazil for the development of resilient peanut cultivars.Na publicação: A. C. G. Araujo