Let the consumer decide? The regulation of commercial genetic testing.

Objectives—The development of predictive genetic tests provides a new area where consumers can gain knowledge of their health status and commercial opportunities. "Over-the-counter" or mail order genetic tests are most likely to provide information on carrier status or the risk of developing a multifactorial disease. The paper considers the social and ethical implications of individuals purchasing genetic tests and whether genetic information is different from other types of health information which individuals can obtain for themselves. Design—The discussion is illustrated by findings from a questionnaire survey of university students as potential consumers. Topics covered included what health tests they had already used, expectations of genetic tests, willingness to pay, who should have access to the results and whether there need to be restrictions on such tests. Sample—Six hundred and fifteen first-year students in the universities of Leuven, Cardiff, Central Lancashire, Vienna and Nijmegen studying either medicine or a non-science subject. Results—Students were enthusiastic about genetic tests and had high expectations of their accuracy and usefulness but most thought they should be available through the health service and a minority thought that some tests, for example for sex selection, should not be available at all. There were few differences in responses by sex or subject of study but some by country. The paper also considers ethical and social issues outside the scope of a questionnaire survey of this type. Conclusion—To address some of these issues the sale of genetic tests to individuals can be made subject to ethical guidelines or codes of practice, for example to protect vulnerable groups, but there are fundamental social and ethical questions which such guidelines cannot address

An optimised scalable synthesis of H2O@C60and a new synthesis of H2@C60

New high-yielding synthetic routes to the small-molecule endofullerenes H2O@C60, D2O@C60 and H2@C60 are described. The use of high temperatures and pressures for the endohedral molecule incorporation are avoided. A new partial closure step using PPh3, and final suturing using a novel Diels–Alder/retro-Diels–Alder sequence are amongst the advances reported

Compressive Fourier Transform Spectroscopy

We describe an approach based on compressive-sampling which allows for a considerable reduction in the acquisition time in Fourier-transform spectroscopy. In this approach, an N-point Fourier spectrum is resolved from much less than N time-domain measurements using a compressive-sensing reconstruction algorithm. We demonstrate the technique by resolving sparse vibrational spectra using <25% of the Nyquist rate samples in single-pulse CARS experiments. The method requires no modifications to the experimental setup and can be directly applied to any Fourier-transform spectroscopy measurement, in particular multidimensional spectroscopy

Tree-irreducible automorphisms of free groups

We introduce a new class of automorphisms $\varphi$ of the non-abelian free group $F_N$ of finite rank $N \geq 2$ which contains all iwips (= fully irreducible automorphisms), but also any automorphism induced by a pseudo-Anosov homeomorphism of a surface with arbitrary many boundary components. More generally, there may be subgroups of $F_N$ of rank $\geq 2$ on which $\varphi$ restricts to the identity. We prove some basic facts about such {\em tree-irreducible} automorphisms, and show that, together with Dehn twist automorphisms, they are the natural basic building blocks from which any automorphism of \FN can be constructed in a train track set-up. We then show: {\bf Theorem:} {\it Every tree-irreducible automorphism of $F_N$ has induced North-South dynamics on the Thurston compactification $\bar{\rm CV}_N$ of Outer space.} Finally, we define a "blow-up" construction on the vertices of a train track map, which, starting from iwips, produces tree-irreducible automorphisms which in general are not iwip

Some major impacts of the national space program. 3 - Astronomy as an example of scientific impacts

Impact of space exploration on astronomy and human cultur

Non-Markovian entanglement dynamics in the presence of system-bath coherence

A complete treatment of the entanglement of two-level systems, which evolves through the contact with a thermal bath, must include the fact that the system and the bath are not fully separable. Therefore, quantum coherent superpositions of system and bath states, which are almost never fully included in theoretical models, are invariably present when an entangled state is prepared experimentally. We show their importance for the time evolution of the entanglement of two qubits coupled to independent baths. In addition, our treatment is able to handle slow and low-temperature thermal baths.Comment: Accepted for publication in Phys. Rev. Lett

Fault tolerant architectures for integrated aircraft electronics systems

Work into possible architectures for future flight control computer systems is described. Ada for Fault-Tolerant Systems, the NETS Network Error-Tolerant System architecture, and voting in asynchronous systems are covered

Congressional Distributive Politics and State Economic Performance

This paper tests several theories of the effects of congressional representation on state economic growth. States that were represented by very senior Democratic congressmen grew more quickly during the 1953-1990 period than states that were represented by more junior congressional delegations. We find some, but weaker, evidence that states with a high fraction of their delegation on particularly influential committees also exhibit above-average growth. We also test partisan models of distributive politics by studying the relationship between a state's degree of political competition and its growth rate. Our findings support both nonpartisan and partisan models of congressional distributive politics. In spite of our findings with respect to economic growth, we can not detect any substantively important association between congressional delegation seniority, the degree of state political competition, and the geographic distribution of federal funds. The source of the growth relationships we identify therefore remains an open question.

ELSA: An Integrated, Semi-Automated Nebular Abundance Package

We present ELSA, a new modular software package, written in C, to analyze and manage spectroscopic data from emission-line objects. In addition to calculating plasma diagnostics and abundances from nebular emission lines, the software provides a number of convenient features including the ability to ingest logs produced by IRAF's splot task, to semi-automatically merge spectra in different wavelength ranges, and to automatically generate various data tables in machine-readable or LaTeX format. ELSA features a highly sophisticated interstellar reddening correction scheme that takes into account temperature and density effects as well as He II contamination of the hydrogen Balmer lines. Abundance calculations are performed using a 5-level atom approximation with recent atomic data, based on R. Henry's ABUN program. Improvements planned in the near future include use of a three-region ionization model, similar to IRAF's nebular package, error propagation, and the addition of ultraviolet and infrared line analysis capability. Detailed documentation for all aspects of ELSA are available at http://www.williams.edu/Astronomy/research/PN .Comment: 2 pages, contributed paper, IAU Symp. 234, Planetary Nebulae in Our Galaxy and Beyon