2,439 research outputs found

    Parental bonding and parent-child relationship among tertiary students

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    Parental bonding is an important predictor that gives a lot of insight into parent-child relationship. Studies have demonstrated the importance of parent child relationship for adjustment, ranging from attachment during infancy, indiscipline style during childhood and adolescence to parenting style during adulthood. This paper aims to investigate the relationship between parental bonding and parent-child relationship among tertiary level students in which gender and cultural effects were also taken into consideration. A survey with two valid inventories?Parental Bonding Inventory (PBI) and Parent-Child Relationship Survey (PCRS) was carried out on 160 tertiary level students from Selangor. Results indicate that stronger parental bonding promotes better parent-child relationship. Besides, females were found to have better parental bonding as well as parent-child relationship compared to males. From a cultural aspect, there is no difference among races in terms of parental bonding and parent-child relationship

    C1q/TNF-related protein 3 (CTRP3) and 9 (CTRP9) concentrations are decreased in patients with heart failure and are associated with increased morbidity and mortality.

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    BACKGROUND: Biochemical marker has revolutionized the approach to the diagnosis of heart failure. However, it remains difficult to assess stability of the patient. As such, novel means of stratifying disease severity are needed. C1q/TNF-Related Protein 3 (CTRP3) and C1q/TNF-Related Protein 9 (CTRP9) are novel adipokines that contribute to energy homeostasis with additional anti-inflammatory and anti-ischemic properties. The aim of our study is to evaluate concentrations of CTRP3 and CTRP9 in patients with HFrEF (heart failure with reduced ejection fraction) and whether associated with mortality. METHODS: Clinical data and plasma were obtained from 176 healthy controls and 168 patients with HFrEF. CTRP3 and CTRP9 levels were evaluated by enzyme-linked immunosorbent assay. RESULTS: Both CTRP3 and CTRP9 concentrations were significantly decreased in the HFrEF group compared to the control group (p \u3c 0.001). Moreover, patients with higher New York Heart Association class had significantly lower CTRP3 or CTRP9 concentrations. Correlation analysis revealed that CTRP3 and CTRP9 levels were positively related with LVEF% (CTRP3, r = 0.556, p \u3c 0.001; CTRP9, r = 0.526, p \u3c 0.001) and negatively related with NT-proBNP levels (CTRP3, r = - 0.454, p \u3c 0.001; CTRP9, r = - 0.483, p \u3c 0.001). After a follow up for 36 months, after adjusted for age, LVEF and NT-proBNP, we observed that CTRP3 or CTRP9 levels below the 25th percentile was a predictor of total mortality (CTRP3,HR:1.93,95%CI1.03~3.62,P = 0.042;CTRP9,HR:1.98,95%CI:1.02~3.85,P = 0.044) and hospitalizations (CTRP3,HR:2.34,95% CI:1.43~3.82,P = 0.001;CTRP9,HR:2.67,95%CI:1.58~4.50,P \u3c 0.001). CONCLUSIONS: CTRP3 and CTRP9 are decreased in patients with HFrEF, proportionate to disease severity, and each is associated with increased morbidity and mortality. TRIAL REGISTRATION: NCT01372800 . Registered May 2011

    Exploring the ‘middle ground’ between state and market: the example of China

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    Studies of housing systems lying in the ‘middle ground’ between state and market are subject to three important shortcomings. First, the widely used Esping-Andersen (EA) approach assesses only a subset of the key housing outcomes and may be less helpful for describing changes in housing policy regimes. Second, there is too much emphasis on tenure transitions, and an assumed close correspondence between tenure labels and effective system functioning may not be valid. Third, due attention has not been given to the spatial dimensions in which housing systems operate, in particular when housing policies have a significant devolved or localised emphasis. Updating EA’s framework, we suggest a preliminary list of housing system indicators in order to capture the nature of the housing systems being developed and devolved. We verified the applicability of this indicator system with the case of China. This illustrates clearly the need for a more nuanced and systematic basis for categorising differences and changes in welfare and housing policies

    Repenser la gestion des espèces végétales exotiques envahissantes au site patrimonial du Mont-Royal avec le concept de nouvel écosystème

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    Généralement, les plantes exotiques envahissantes sont perçues comme une menace pour la biodiversité. Cependant, peu de celles ayant été introduites dans l’est du Canada ont eu des effets négatifs sur la faune et la flore indigène. Certains chercheurs se questionnent donc quant à cette perception négative des espèces végétales exotiques envahissantes et suggèrent de modifier cette vision en intégrant le concept de nouvel écosystème (novel ecosystem. Ce dernier permet non seulement de réfléchir et de repenser la place des EVEE au sein des écosystèmes, mais également de redéfinir les objectifs entourant leur gestion pour qu’ils soient mieux adaptés aux contextes biophysiques et paysagers en place. L’objectif principal de cet essai est donc de proposer une démarche intégrant le concept de nouvel écosystème dans la gestion des espèces végétales exotiques envahissantes au Québec, et plus particulièrement au site patrimonial du Mont-Royal, appelé communément la montagne. Pour ce faire, plusieurs caractéristiques de l’écosystème de la montagne ont été évaluées à l’aide d’un cadre décisionnel. Les résultats de l’analyse montrent que l’écosystème du site patrimonial du Mont-Royal correspond à un nouvel écosystème, car la composition du milieu diffère de ce qui prévalait historiquement et qu’il n’y a pas de possibilité que l’écosystème puisse se rétablir sans intervention. En effet, les transformations du paysage en lien avec l’urbanisation et les pratiques horticoles en place ont profondément modifié la dynamique écologique naturelle du mont Royal. De plus, certains obstacles au rétablissement d’ordre économique, social et environnemental continuent d’exercer des pressions sur le milieu, notamment l’épidémie d’agrile du frêne, le développement immobilier et les changements climatiques. De ce fait, une priorisation des actions à mettre en place est essentielle pour assurer une gestion durable des espèces végétales exotiques envahissantes. Pour ce faire, les espèces ayant un potentiel d’envahissement élevé doivent être ciblées, alors que la présence de celles comportant moins de risques de devenir nuisibles doit être acceptée. L’Index of alien impact (IAI utilisé pour sélectionner les espèces pouvant engendrer le plus d’effets négatifs sur le milieu montre que les espèces prioritaires sont la renouée du Japon (Reynoutria japonica, le brome inerme (Bromus inermis, le dompte-venin de Russie (Vincetoxicum rossicum, le nerprun cathartique (Rhamnus cathartica et le roseau commun (Phragmites australis subsp. australis. Les objectifs et les méthodes de contrôle doivent être adaptés en fonction de chaque espèce, et doivent prendre en considération la superficie d’envahissement ainsi que le niveau d’implantation de la plante sur l’ensemble du site patrimonial du Mont-Royal. Des recommandations plus générales pour parvenir à une gestion optimale des espèces végétales exotiques envahissantes incluent la mise en place de méthodes de prévention, l’implantation de suivis et d’inventaires floristiques annuels et la coordination des actions entre les parties prenantes

    Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase

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    Indexación: ScopusNovel bone regeneration approaches aim to obtain immature osteoblasts from somatic stem cells. Umbilical cord Wharton's jelly mesenchymal stem cells (WJ-MSCs) are an ideal source for cell therapy. Hence, the study of mechanisms involved in WJ-MSC osteoblastic differentiation is crucial to exploit their developmental capacity. Here, we have assessed epigenetic control of the Runt-related transcription factor 2 (RUNX2) osteogenic master regulator gene in WJ-MSC. We present evidence indicating that modulation of RUNX2 expression through preventing Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase activity is relevant to enhance WJ-MSC osteoblastic potential. Hence, JARID1B loss of function in WJ-MSC results in increased RUNX2/p57 expression. Our data highlight JARID1B activity as a novel target to modulate WJ-MSC osteoblastic differentiation with potential applications in bone tissue engineering. Stem Cells 2017;35:2430–2441. © 2017 AlphaMed Presshttps://academic-oup-com.recursosbiblioteca.unab.cl/stmcls/article/36/4/631/645310

    Testing Heteroscedasticity in Nonparametric Regression Based on Trend Analysis

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    We first propose in this paper a new test method for detecting heteroscedasticity of the error term in nonparametric regression. Some simulation experiments are then conducted to evaluate the performance of the proposed methodology. A real-world data set is finally analyzed to demonstrate the application of the method
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