Systemic Predictive Safety Analysis of Pedestrian Crashes for Montgomery County’s Vision Zero Program

The goal of Vision Zero is the prevention of all traffic fatalities and serious injuries. Although traditional transportation planning is reactive to locations where serious crashes occur, some agencies are taking a more proactive approach to safety to improve locations with high expected crashes before someone is seriously injured or killed. This paper presents the results of a systemic safety analysis that produced two pedestrian-related safety performance functions for Montgomery County, MD, including 1) motor vehicle crashes with pedestrians at intersections at night and 2) through-movement motor vehicle crashes with pedestrians at road sections. These models were built using negative binomial regression of police-reported crash data collected from 2015 to 2019 for most of the county road network integrated with land use-, demographic-, and roadway variables collected by the Montgomery County Planning Department for 16,387 intersections (stop-controlled and signalized) and 29,715 segments (all functional classifications except freeways). Both models identified key transportation-related exposure variables, including motor vehicle and pedestrian volumes, proximity to transit, and crosswalk locations; they also presented land use contexts that may explain where pedestrians are likely to walk and be exposed to crash risks. These results build on current systemic safety literature and demonstrate the data collection and analysis methods that can be used in a county-level Vision Zero context to improve safety for all who walk. This paper summarizes the analysis approach, including exposure modeling, crash modeling, and applications for identifying both high-risk locations and potential mitigations. Considerations for equity and long-term planning are also discussed

New England Food Vision: Healthy Food for All, Sustainable Farming and Fishing, Thriving Communities

A New England Food Vision proposes changes in food production, distribution, and consumption reaching from the most rural areas to the densest cities—across the entire food system. The New England Food Vision Writing Team has been working since 2011 to produce a bold vision that calls for our region to build the capacity to produce at least 50% of clean, fair, accessible and just food for New Englanders by 2060. The Vision includes a set of guiding assumptions and calculations that sketch a future in which diverse local and state food systems are supported by and in turn support a regional sustainable food system. The roles of the writing team include production of a New England Food Vision document, including input from regional stakeholders at the annual New England Food Summits, discussions at various meetings, presentations, and via an online survey

Myocardial Infarction Accelerates Atherosclerosis

During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a high risk of recurrent events for unknown reasons. Here we show that the systemic response to ischemic injury aggravates chronic atherosclerosis. After myocardial infarction or stroke, apoE$^{−/−}$ mice developed larger atherosclerotic lesions with a more advanced morphology. This disease acceleration persisted over many weeks and was associated with markedly increased monocyte recruitment. When seeking the source of surplus monocytes in plaque, we found that myocardial infarction liberated hematopoietic stem and progenitor cells from bone marrow niches via sympathetic nervous system signaling. The progenitors then seeded the spleen yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression

Work Zone Intrusion Report Interface Design

While necessary for roadways, work zones present a safety risk to crew. Half of road workers deaths between 2005 and 2010 were due to collisions with motorists intruding on the work zone. Therefore, addressing intrusions is an important step for ensuring a safe work environment for crewmembers. However, a recent research synthesis at the Minnesota Department of Transportation found that few states had an explicit method for systematically collecting work zone intrusion data. The purpose of this work zone intrusion interface design project was to design an efficient, comprehensive, and user-friendly reporting system for intrusions in work zones. A user-centric, iterative design process was employed to design an adaptable web-based and paper report to account for simple documentation of intrusions not deemed a threat to worker safety and a detailed report for more thorough documentation of serious intrusion events. Final recommendations include organizational changes and support to encourage workers to complete the form and provide valuable data to the state

Circulating neutrophil-related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study.

AIMS: Neutrophil activity contributes to adverse cardiac remodelling in experimental acute cardiac injury and is modifiable with pharmacologic agents like colchicine. METHODS AND RESULTS: Neutrophil activity-related plasma proteins known to be affected by colchicine treatment were measured at Visit 3 (1993-1995) and Visit 5 (2011-2013) of the ARIC cohort study. A protein-based neutrophil activity score was derived from 10 candidate proteins using LASSO Cox regression. Associations with incident heart failure (HF) and with cardiac function using Cox proportional hazards regression and linear regression models, respectively. The mean ages at Visits 3 and 5 were 60 ± 6 and 75 ± 5 years, respectively, and 54% and 57% were women, respectively. Each 1-standard deviation increase in the neutrophil activity score was associated with a higher risk of incident HF in mid-life (hazard ratio [HR] 1.31, 95% confidence interval [CI] 1.25-1.37) and late-life (HR 1.23, 95% CI 1.14-1.34), with a higher HR for HF with preserved than reduced ejection fraction (HR 1.30, 95% CI 1.16-1.47 vs. HR 1.13, 95% CI 0.98-1.30). Higher neutrophil activity was associated with greater left ventricular end-diastolic volume index, mass index and diastolic and systolic dysfunction. CONCLUSIONS: Plasma proteins related to neutrophil function associate with incident HF in mid- and late-life and with adverse cardiac remodelling. Therapies that modify these proteins, such as colchicine, may represent promising targets for the prevention or treatment of HF

Changing the intellectual climate

Calls for more broad-based, integrated, useful knowledge now abound in the world of global environmental change (GEC) science. They evidence many scientists’ desire to help humanity confront the momentous biophysical implications of its own actions. But they also reveal a limited conception of social science and virtually ignore the humanities. They thereby endorse a stunted conception of ‘human dimensions’ at a time when the challenges posed by GEC are increasing in magnitude, scale and scope. Here we make the case for a richer conception predicated on broader intellectual engagement. We then identify some of its practical preconditions. Interdisciplinary dialogue, we suggest, should engender plural representations of Earth’s present and future reflective of divergent human values and aspirations. In turn, this might insure publics and decision makers against overly narrow conceptions of what is possible and desirable as they consider the profound questions raised by GEC

Rapid and High-Throughput pan-Orthopoxvirus Detection and Identification using PCR and Mass Spectrometry

The genus Orthopoxvirus contains several species of related viruses, including the causative agent of smallpox (Variola virus). In addition to smallpox, several other members of the genus are capable of causing human infection, including monkeypox, cowpox, and other zoonotic rodent-borne poxviruses. Therefore, a single assay that can accurately identify all orthopoxviruses could provide a valuable tool for rapid broad orthopovirus identification. We have developed a pan-Orthopoxvirus assay for identification of all members of the genus based on four PCR reactions targeting Orthopoxvirus DNA and RNA helicase and polymerase genes. The amplicons are detected using electrospray ionization-mass spectrometry (PCR/ESI-MS) on the Ibis T5000 system. We demonstrate that the assay can detect and identify a diverse collection of orthopoxviruses, provide sub-species information and characterize viruses from the blood of rabbitpox infected rabbits. The assay is sensitive at the stochastic limit of PCR and detected virus in blood containing approximately six plaque-forming units per milliliter from a rabbitpox virus-infected rabbit

Alzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals

Background: Both Alzheimer’s disease (AD) genetic risk factors and indices of cognitive reserve (CR) influence risk of cognitive decline, but it remains unclear whether they interact. This study examined whether a CR index score modifies the relationship between AD genetic risk factors and long-term cognitive trajectories in a large sample of individuals with normal cognition. Methods: Analyses used data from the Preclinical AD Consortium, including harmonized data from 5 longitudinal cohort studies. Participants were cognitively normal at baseline (M baseline age = 64 years, 59% female) and underwent 10 years of follow-up, on average. AD genetic risk was measured by (i) apolipoprotein-E (APOE) genetic status (APOE-ε2 and APOE-ε4 vs. APOE-ε3; N = 1819) and (ii) AD polygenic risk scores (AD-PRS; N = 1175). A CR index was calculated by combining years of education and literacy scores. Longitudinal cognitive performance was measured by harmonized factor scores for global cognition, episodic memory, and executive function. Results: In mixed-effects models, higher CR index scores were associated with better baseline cognitive performance for all cognitive outcomes. APOE-ε4 genotype and AD-PRS that included the APOE region (AD-PRSAPOE) were associated with declines in all cognitive domains, whereas AD-PRS that excluded the APOE region (AD-PRSw/oAPOE) was associated with declines in executive function and global cognition, but not memory. There were significant 3-way CR index score × APOE-ε4 × time interactions for the global (p = 0.04, effect size = 0.16) and memory scores (p = 0.01, effect size = 0.22), indicating the negative effect of APOE-ε4 genotype on global and episodic memory score change was attenuated among individuals with higher CR index scores. In contrast, levels of CR did not attenuate APOE-ε4-related declines in executive function or declines associated with higher AD-PRS. APOE-ε2 genotype was unrelated to cognition. Conclusions: These results suggest that APOE-ε4 and non-APOE-ε4 AD polygenic risk are independently associated with global cognitive and executive function declines among individuals with normal cognition at baseline, but only APOE-ε4 is associated with declines in episodic memory. Importantly, higher levels of CR may mitigate APOE-ε4-related declines in some cognitive domains. Future research is needed to address study limitations, including generalizability due to cohort demographic characteristics