Why Disability Studies Scholars Must Challenge Transmisogyny and Transphobia

We argue the need for coalition between trans and disability studies and activism, and that Disability Studies gives us the tools for this task. Our argument rests upon six facets. First and foremost, we explicitly acknowledge the existence of trans disabled people, arguing that Disability Studies must recognise the diversity of disabled people’s lives. Second, we consider how the homogenisation of womanhood, too often employed in transmisogonist arguments particularly when coming from those claiming to be feminists, harm both non-disabled trans women and cis disabled women. This leads to our third point, that Feminist Disability studies must be anti-reductive, exploring how gendered experiences rest upon other social positions (disability, queerness, race etc.) Fourth, we reflect upon the ways in which Disability Studies and feminism share a struggle for bodily autonomy, and that this should include trans people’s bodily autonomy. Finally, we argue that Trans and Disability Studies and activism share complex and critical relationships with medicine, making Disability and Trans Studies useful allies in the fight for better universal health care. We conclude by calling for our colleagues in Disability Studies to challenge transmisogony and transphobia and that transphobia is not compatible with Disability Studies perspectives

Infrared absorption in thin metallic films

Thesis (M.Sc.) -- University of Adelaide, Dept. of Physics, 197

3DStock: A new kind of three-dimensional model of the building stock of England and Wales, for use in energy analysis

This article describes the development of a new three-dimensional model of the British building stock, called ‘3DStock’. The model differs from other 3D urban and stock models, in that it represents explicitly and in detail the spatial relationships between ‘premises’ and ‘buildings’. It also represents the pattern of activities on different floors within buildings. The geometrical/geographical structure of the model is assembled automatically from two existing national data sets. Additional data from other sources including figures for electricity and gas consumption are then attached. Some sample results are given for energy use intensities. The first purpose of the model is in the analysis of energy use in the building stock. With actual energy data for very large numbers of premises, it is possible to take a completely new type of statistical approach, in which consumption can be related to a range of characteristics including activity, built form, construction and materials. Models have been built to date of the London Borough of Camden and the cities of Leicester, Tamworth and Swindon. Work is in progress to extend the modelling to other parts of Britain. Because of the coverage of the data, this will be limited however to England and Wales

Three-Dimensional High-Resolution Urban Thermal & Mechanical Large Eddy Simulation Interactive Physics Between Buildings, Land Cover And Trees

This paper describes the development of a 3D model of the non-domestic building stock of England and Wales. The model’s purpose is to assess energy use in the stock, and study conservation options. Previous stock models have used data on floor area by activities, and have not represented building geometry. The present model by contrast combines digital maps and property taxation data to build a 3D representation in which separate premises are located within buildings, with floor areas on each level. Sub-activities per floor are also represented in 2D. A case study of the London Borough of Camden is presented

[Letter to the editor] Telomere fusions associate with coding sequence and copy number alterations in CLL

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Pedagogical possibilities for unruly bodies

Project Re•Vision uses disability arts to disrupt stereotypical understandings of disability and difference that create barriers to healthcare. In this paper, we examine how digital stories produced through Re•Vision disrupt biopedagogies by working as body-becoming pedagogies to create nondidactic possibilities for living in/with difference. We engage in meaning making about eight stories made by women and trans people living with disabilities and differences, with our interpretations guided by the following considerations: what these stories ‘teach’ about new ways of living with disability; how these stories resist neoliberalism through their production of new possibilities for living; how digital stories wrestle with representing disability in a culture in which disabled bodies are on display or hidden away; how vulnerability and receptivity become ‘conditions of possibility’ for the embodiments represented in digital stories; and how curatorial practice allows disability-identified artists to explore possibilities of ‘looking back’ at ableist gazes

The vulnerability of refrigerated food to unstable power supplies

This paper describes a simplified model for estimating the vulnerability to spoilage of a number of refrigerated foods in households, resulting from interruptions to the electricity power grid. The tool is demonstrated on a sample of three foods (milk, chicken and fish) in India, which historically has suffered significant interruptions. The effect of interruptions is quantified in terms of tonnage and monetary value of potential losses, in a number of simple scenarios. These losses are estimated for rural and urban areas of each Indian state. Our model indicates that extensions to the duration of power supply interruptions increases potential losses in domestic refrigerators, and that these losses are considerable when compared to losses expected in previous stages of the food supply chain. The current model’s estimation of weight of food lost may be converted to a nutritional value, which opens an opportunity for new multidisciplinary areas of research

Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4

Telomeres shorten with each cell division and can ultimately become substrates for non-homologous end-joining repair, leading to large-scale genomic rearrangements of the kind frequently observed in human cancers. We have characterised over 1400 telomere fusion events at the single-molecule level, using a combination of high-throughput sequence analysis together with experimentally-induced telomeric double-stranded DNA breaks. We show that a single chromosomal dysfunctional telomere can fuse with diverse non-telomeric genomic loci, even in the presence of an otherwise stable genome, and that fusion predominates in coding regions. Fusion frequency was markedly increased in the absence of TP53 checkpoint control and significantly modulated by the cellular capacity for classical, versus alternative, non-homologous end joining (NHEJ). We observed a striking reduction in inter-chromosomal fusion events in cells lacking DNA ligase 4, in contrast to a remarkably consistent profile of intra-chromosomal fusion in the context of multiple genetic knockouts, including DNA ligase 3 and 4 double-knockouts. We reveal distinct mutational signatures associated with classical NHEJ-mediated inter-chromosomal, as opposed to alternative NHEJ-mediated intra-chromosomal telomere fusions and evidence an unanticipated sufficiency of DNA ligase 1 for these intra-chromosomal events. Our findings have implications for mechanisms driving cancer genome evolution

17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors

Clinical observations imply that female cocaine addicts experience enhanced relapse vulnerability compared with males, an effect tied to elevated estrogen phases of the ovarian hormone cycle. Although estrogens can enhance drug-seeking behavior, they do not directly induce reinstatement on their own. To model this phenomenon, we tested whether an estrogen could augment drug-seeking behavior in response to an ordinarily subthreshold reinstatement trigger. Following cocaine self-administration and extinction, female rats were ovariectomized to isolate estrogen effects on reinstatement. Although neither peak proestrus levels of the primary estrogen 17β-estradiol (E2; 10 μg/kg, i.p., 1-h pretreatment) nor a subthreshold cocaine dose (1.25 mg/kg, i.p.) alone were sufficient to reinstate drug-seeking behavior, pretreatment with E2 potentiated reinstatement to the ordinarily subthreshold cocaine dose. Furthermore, E2 microinfusions revealed that E2 (5 μg/0.3 μl, 15-min pretreatment) acts directly within the prelimbic prefrontal cortex (PrL-PFC) to potentiate reinstatement. As E2 has been implicated in endocannabinoid mobilization, which can disinhibit PrL-PFC projection neurons, we investigated whether cannabinoid type-1 receptor (CB1R) activation is necessary for E2 to potentiate reinstatement. The CB1R antagonist AM251 (1 or 3 mg/kg, i.p., 30-min pretreatment) administered prior to E2 and cocaine suppressed reinstatement in a dose-dependent manner. Finally, PrL-PFC AM251 microinfusions (300 ng/side, 15-min pretreatment) also suppressed E2-potentiated reinstatement. Together, these results suggest that E2 can augment reactivity to an ordinarily subthreshold relapse trigger in a PrL-PFC CB1R activation-dependent manner