Stress: A Burning Issue of Today’s Era - An Integrative Review with Ayurvedic Insight

Stress has emerged as a global public health concern, affecting individuals across age groups and professions. It contributes significantly to physical, emotional, and behavioral disorders. This article explores the multifaceted nature of stress, including its etiology, physiological mechanisms, impacts across different life domains, and current evidence-based management strategies. Emphasis is placed on the urgent need for comprehensive and integrative approaches to mitigate stress and its cascading effects, including insights from Ayurveda

Seroprevalence of HIV in blood donors at tertiary care center, M.Y.H. Indore, India

Background: Transfusion of blood has become an important mode of transmission of infections such as human immunodeficiency virus and hepatitis B to the recipients. Blood transfusion is a boon in medical era if properly screened. The aim of study was to determine the seroprevalence of HIV donors in blood bank at M.Y.H. Indore.Methods: The study was conducted in the blood bank, M.Y.H. Hospital, Indore. Total 115775 donors attending blood bank were included in the study. All the donor samples were screened for detection of antibodies for human immunodeficiency virus by microwell Enzyme Linked Immunosorption Assay (ELISA) method. The seroprevalence of HIV infection among the donors was determined over a period of five years since January 2013 to December 2017.Results: Total 115775 blood donors were recorded. Out of total 115775 blood donors included in the study, replacement donor were 10766 (9.29%) while voluntary donor were 105009 (90.70%). In the duration of five-year study period, total 80 cases (0.06%) were reactive to HIV. Out of total 115775 blood donors included in the study, maximum cases i.e. 22 (0.08%) cases were found to be positive for HIV infection in year 2017. Out of 10766 replacement donors included in the study, 64 cases (0.59%) were reactive to HIV infection. While out of 105009 voluntary donors, 16 cases (0.01%) were found to be reactive to HIV infection. Voluntary donors are more as compared to the replacement donors. Number of HIV positive patients were found to more in replacement donor as compared to the voluntary donors.Conclusions: The seroprevalence of HIV is low in this study and hence it is concluded that the more the number of voluntary donors, the less the number of HIV positive cases. Voluntary donors can be motivated by proper health education and high quality screening programs

Bone marrow evaluation of patients having pancytopenia at tertiary care center, M. Y. hospital, Indore, India: one-year study

Background: Pancytopenia is reduction of all three formed elements of blood below the normal reference range leading to anemia, leucopenia, thrombocytopenia. Bone marrow aspiration is extremely helpful in evaluating the cause of pancytopenia by cellularity and cytology in order to prevent grave complications and mortality as the underlying pathology determines the management and prognosis of the patients. Aim of research study was to evaluate the patients having pancytopenia at tertiary care center, M.Y.H. Hospital, Indore, India.Methods: The present study was carried out over a period of one year from 2017 to 2018, in the Department of Pathology, M. Y. Hospital, Indore. During this period, a total of 109 bone marrow smears were examined. Out of these, 42 cases had the clinical presentation of pancytopenia. A detailed study was done regarding clinical examination and hematological and radiological investigations.Results: In this study 42 cases of pancytopenia were examined over a period of one year. The commonest cause of pancytopenia was megaloblastic anemia (33.34%) followed by aplastic anemia (19.05%). Others includes myelodysplastic syndrome (MDS), acute leukemia, erythroid hyperplasia and plasmacytosis.Conclusions: Bone marrow aspiration can diagnose majority of the cases of pancytopenia. Megaloblastic anemia and aplastic anemia are the commonest causes of pancytopenia

Power Transformer Monitoring System

Monitoring and diagnosis of power as well as distribution transformer is the most important process for extending the life of transformer. A transformer monitoring system is already developed by Siemens which is based on SCADA system. But that system can’t be used in small scale industry because most of the industry lacks in automation. This paper presents the details of a monitoring system which is a standalone device equipped on every transformer individually and this device is able to detect phase failure, unbalanced voltage, and earth fault. Apart from these, the device can also monitor the oil level and oil temperature. The main aim of research is to develop this product and make available on economic rates.

SYNTHESIS AND ANTIOXIDANT ACTIVITY OF NOVEL 2-ARYL SUBSTITUTED BENZOTHIAZOLE DERIVATIVES

Objective: A series of 2-aryl substituted benzothiazole was designed and synthesized with various substituted benzoic acid. 2-mercaptobenzothiazole and thionyl chloride also used to get carbothiaote. The present study was carried to assess the pharmacological potential towards antioxidant activity of 2-aryl substituted benzothiazole derivatives. Methods: The antioxidant activity of the synthesized compounds was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH), and superoxide radical scavenging assay methods. Results: Compounds showed significant radical scavenging potential due to the presence of electron donating substituent. Conclusion: These indicate that benzothiazole derivatives showed the defence mechanism to prevent formation of excess free radicals

Connectify: An Interactive Social Media App with Personalization

This research paper presents the design, development, and deployment process of a modern social media application aimed at facilitating digital interaction and content sharing among users. The application features a userfriendly interface, secure authentication, post creation, real-time updates, and user engagement features such as likes and comments. Using modern web technologies and frameworks like the MERN stack (MongoDB, Express, React, and Node.js), the application offers scalability, performance, and interactivity. This paper also discusses the challenges encountered, solutions implemented, and future scope for improvement

Palladium- and base-free synthesis of conjugated ynones by cross-coupling reactions of alkynylboronates with acid chlorides mediated by CuCl

Alkynylboronates can be employed as a practical and versatile precursor for a variety of pi-conjugated organic compounds. In the presence of Cu(I) salt, cross-coupling reactions of acid chlorides with alkynylboronates giving rise to the corresponding conjugated ynones takes place readily in aprotic polar solvents such as DMI under neutral conditions

Cyclocarbonylative Sonogashira Reactions of 1-Ethynylbenzyl Alcohols: Synthesis of 1-Carbonylmethylene-1,3-Dihydroisobenzofurans

In this work, we present a carbonylative Sonogashira reaction of o-ethynyl benzyl alcohols and aryl iodides, followed by a cyclization process to selectively give carbonylmethylene isobenzofurans in high yields and in an atom-economic fashion. The reaction can be carried out in the absence of CuI, with a small amount of PdCl2(PPh3)2 (0.2–0.5 mol-%), using aryl iodides bearing both electron-withdrawing and electron-donating groups. Of the two possible stereoisomeric products, Z-isobenzofuran derivatives were obtained as major products. But, when the reaction was extended to a secondary alcohol, an interesting switch in stereoselectivity was observed