Phase relations in the Ta2O5-WO3-SiO2 system

Subsolidus relations and liquidus boundaries in the TaO-WO-SiO system at temperatures ranging from 1200 °C to 1500 °C were investigated. Phase diagrams were constructed. Compounds with stoichiometries of TaWO, TaWO and TaWO formed in the TaO-WO subsystem at 1200 °C. SiO was compatible with each of the compounds. A solid solution with a formula of (1 − x) TaO·xWO formed on the TaO-WO line in the compositional range of TaO:WO > 11:4. SiO had a maximum solubility of 25% SiO in the solid solution. Liquid phase first appeared in the WO-rich corner at 1300 °C. As the temperature was increased up to 1500 °C, the liquidus area boundary gradually expanded towards the SiO- and the TaO-rich corners

Chinese herbal medicine promotes growth by improving nutrient utilization and rumen microbiota in suckling lambs

This study investigated the effects of compound Chinese herbal medicine (CCHM) on nutrient digestibility, rumen fermentation parameters, and microbial structure in suckling lambs. Sixty Lambs born as twins (from the same ewe), each 8 days old, were randomly assigned to two groups. The control and treatment groups received 0 and 0.2% CCHM in the basal diet, respectively. Digestion experiments were conducted during the trial. Rumen fluid samples were collected from slaughtered lambs in the final week for microbiome analysis. The results indicated that average daily gain and average daily feed intake were significantly improved by CCHM. The apparent digestibility of dry matter and acid detergent fiber also increased significantly. CCHM supplementation elevated Ammonia nitrogen (NH3-N), total volatile fatty acids (TVFAs), acetate, and propionate concentrations in the rumen. The relative abundance of Firmicutes, Actinobacteria, Patescibacteria, Succiniclasticum, Selenomonas, Olsenella, and Shuttleworthia increased in the treatment group. Linear discriminant analysis Effect Size (LEfSe) revealed ten bacterial groups significantly enriched in the treatment group. These included Patescibacteria (Phylum), Negativicutes and Saccharimonadia (Class), Saccharimonadia and Rhodobacterales (Order), Saccharimonadiahe and Rhodobacteraceae (Family), and Prevotell-9, Saccharimonadales, and Limosilicobacillus (Genus). Thirteen CAZyme families were detected. Two enzyme families, GH34-5 and CBM4, were enriched in the control group, while eleven families were enriched in the treatment group: GT14, GH89, GH84, GH63, GH5-36, CBM58, PL37, GH85, GH165, GH110, and GH50. Correlation analysis between rumen bacteria, carbohydrate enzymes, and fermentation parameters showed a positive correlation between Saccharimonadales and GH63. Limosilactobacillus showed a positive correlation with CBM58. Negative correlations were found between Romboutsia and both GT14 and PL37. GH84, GH165, GH85, and GH50 were positively correlated with NH3-N concentration. CBM58, GT14, GH89, GH110, GH50, and PL37 showed positive associations with TVFAs. This study demonstrates that dietary supplementation with CCHM during the suckling period improves growth performance, enhances nutrient digestibility, increases rumen fermentation capacity, modulates microbial abundance, and promotes lamb development in Hu sheep

Preclinical pharmacokinetics, distribution, metabolism and excretion of disitamab vedotin

Background and purpose: Disitamab vedotin is an antibody-drug conjugate (ADC) composed of a humanized IgG1 monoclonal antibody (mAb) targeting HER2 conjugated to monomethyl auristatin E(MMAE) via a cleavable dipeptide linker. Experimental approach: The pharmacokinetics, distribution, catabolism/meta-bolism and elimination properties of disitamab vedotin and its payload MMAE were characterized in rats and tumour-bearing mice. Key results: The configured mAb and total antibody showed linear dynamic characteristics. Moreover, the molecular structure of disitamab vedotin effectively reduces the exposure of MMAE, which has a fast clearance. Two radiolabeled probes were developed to track the fate of different components of the disitamab vedotin, including 125I labelled antibody and 3H labelled MMAE payload of the ADC. Following a single intravenous administration of the radiolabeled probes to the tumour-bearing mice and rats, blood, various tissues, and excreta samples were collected and analyzed for radioactivity and to characterize the metabolites/catabolites. Disitamab vedotin and free MMAE (FM) were majorly distributed in tissues and organs with rich blood flow. Moreover, both disitamab vedotin and MMAE have higher and longer exposure in tumour tissue. Disitamab vedotin was mainly eliminated through renal excretion, while the FM was mainly eliminated through the biliary faecal route (>70 %) and a small fraction (<10 %) was eliminated through renal excretion in the form of catabolites/metabolites, among which, MMAE was identified as the major species, along with 10 other minor species. Conclusion: These studies provided significant insight into disitamab vedotin pharmacokinetics, distribution, metabolism and elimination properties, which supports the clinical development of disitamab vedotin

Exploring Query Understanding for Amazon Product Search

Online shopping platforms, such as Amazon, offer services to billions of people worldwide. Unlike web search or other search engines, product search engines have their unique characteristics, primarily featuring short queries which are mostly a combination of product attributes and structured product search space. The uniqueness of product search underscores the crucial importance of the query understanding component. However, there are limited studies focusing on exploring this impact within real-world product search engines. In this work, we aim to bridge this gap by conducting a comprehensive study and sharing our year-long journey investigating how the query understanding service impacts Amazon Product Search. Firstly, we explore how query understanding-based ranking features influence the ranking process. Next, we delve into how the query understanding system contributes to understanding the performance of a ranking model. Building on the insights gained from our study on the evaluation of the query understanding-based ranking model, we propose a query understanding-based multi-task learning framework for ranking. We present our studies and investigations using the real-world system on Amazon Search

Hello, is anyone in there? : Connecting with the self

The self, such a difficult word to define, also an easy word to understand. This thesis analyzes the self from transpersonal psychology, such as four major archetypes and science of consciousness; attachment theory, such as different attachment styles and their influences, trauma and field of neuroscience; plus the traditional Chinese concepts of Qi and breathing meditation. It is a work with the combination of psychology, neuroscience and phiolosophy.Limeng ChenArbeit an der Bibliothek noch nicht eingelangt - Daten nicht gepr\ufcftMasterarbeit Universit\ue4t Innsbruck 202

Hello, is anyone in there? : Connecting with the self

The self, such a difficult word to define, also an easy word to understand. This thesis analyzes the self from transpersonal psychology, such as four major archetypes and science of consciousness; attachment theory, such as different attachment styles and their influences, trauma and field of neuroscience; plus the traditional Chinese concepts of Qi and breathing meditation. It is a work with the combination of psychology, neuroscience and phiolosophy.Limeng ChenArbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprüftMasterarbeit Universität Innsbruck 202

Hello, is anyone in there? : Connecting with the self

The self, such a difficult word to define, also an easy word to understand. This thesis analyzes the self from transpersonal psychology, such as four major archetypes and science of consciousness; attachment theory, such as different attachment styles and their influences, trauma and field of neuroscience; plus the traditional Chinese concepts of Qi and breathing meditation. It is a work with the combination of psychology, neuroscience and phiolosophy.Limeng ChenArbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprüftMasterarbeit Universität Innsbruck 202