Cycloaddition of Aryldiazoacetates With Terminal Alkynes and Nitriles via a Bioinspired Cobalt Complex

In this study, we present a novel method for the efficient cycloaddition of aryl diazoacetates with both terminal alkynes and nitriles, employing a bioinspired cobalt complex as a catalyst. Our findings indicate that terminal alkynes react with aryl diazoacetates to yield a cyclopropenation product through a 2+1 cycloaddition reaction. Meanwhile, nitriles react with aryl diazoacetates to produce an oxazole product via a 2+3 cycloaddition reaction. These results have significant implications for the development of new synthetic routes towards cyclopropenation and oxazole compounds

Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila

Information processing relies on precise patterns of synapses between neurons. The cellular recognition mechanisms regulating this specificity are poorly understood. In the medulla of the Drosophila visual system, different neurons form synaptic connections in different layers. Here, we sought to identify candidate cell recognition molecules underlying this specificity. Using RNA sequencing (RNA-seq), we show that neurons with different synaptic specificities express unique combinations of mRNAs encoding hundreds of cell surface and secreted proteins. Using RNA-seq and protein tagging, we demonstrate that 21 paralogs of the Dpr family, a subclass of immunoglobulin (Ig)-domain containing proteins, are expressed in unique combinations in homologous neurons with different layer-specific synaptic connections. Dpr interacting proteins (DIPs), comprising nine paralogs of another subclass of Ig-containing proteins, are expressed in a complementary layer-specific fashion in a subset of synaptic partners. We propose that pairs of Dpr/DIP paralogs contribute to layer-specific patterns of synaptic connectivity

Promptus: Can Prompts Streaming Replace Video Streaming with Stable Diffusion

With the exponential growth of video traffic, traditional video streaming systems are approaching their limits in compression efficiency and communication capacity. To further reduce bitrate while maintaining quality, we propose Promptus, a disruptive novel system that streaming prompts instead of video content with Stable Diffusion, which converts video frames into a series of "prompts" for delivery. To ensure pixel alignment, a gradient descent-based prompt fitting framework is proposed. To achieve adaptive bitrate for prompts, a low-rank decomposition-based bitrate control algorithm is introduced. For inter-frame compression of prompts, a temporal smoothing-based prompt interpolation algorithm is proposed. Evaluations across various video domains and real network traces demonstrate Promptus can enhance the perceptual quality by 0.111 and 0.092 (in LPIPS) compared to VAE and H.265, respectively, and decreases the ratio of severely distorted frames by 89.3% and 91.7%. Moreover, Promptus achieves real-time video generation from prompts at over 150 FPS. To the best of our knowledge, Promptus is the first attempt to replace video codecs with prompt inversion and the first to use prompt streaming instead of video streaming. Our work opens up a new paradigm for efficient video communication beyond the Shannon limit

Solving dynamic multi-objective optimization problems via support vector machine

Dynamic Multi-objective Optimization Problems (DMOPs) refer to optimization problems that objective functions will change with time. Solving DMOPs implies that the Pareto Optimal Set (POS) at different moments can be accurately found, and this is a very difficult job due to the dynamics of the optimization problems. The POS that have been obtained in the past can help us to find the POS of the next time more quickly and accurately. Therefore, in this paper we present a Support Vector Machine (SVM) based Dynamic Multi-Objective Evolutionary optimization Algorithm, called SVM-DMOEA. The algorithm uses the POS that has been obtained to train a SVM and then take the trained SVM to classify the solutions of the dynamic optimization problem at the next moment, and thus it is able to generate an initial population which consists of different individuals recognized by the trained SVM. The initial populuation can be fed into any population based optimization algorithm, e.g., the Nondominated Sorting Genetic Algorithm II (NSGA-II), to get the POS at that moment. The experimental results show the validity of our proposed approach