A Single‐Cell Perspective of the Mammalian Liver in Health and Disease

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154943/1/hep31149_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154943/2/hep31149.pd

Optical sensor based on hybrid LPG/FBG in D-fiber for simultaneous refractive index and temperature measurement

A dual-parameter optical sensor has been realized by UV-writing a long-period and a Bragg grating structure in D-fiber. The hybrid configuration permits the detection of the temperature from the latter and measuring the external refractive index from the former responses, respectively. The employment of the D-fiber allows as effective modification and enhancement of the device sensitivity by cladding etching. The grating sensor has been used to measure the concentrations of aqueous sugar solutions, demonstrating the potential capability to detect concentration changes as small as 0.01%

hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154982/1/hep30921-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154982/2/hep30921.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154982/3/hep30921_am.pd

Mass Ratio Distribution of Hierarchical Triple Systems from the LAMOST-MRS Survey

Hierarchical triple-star systems consists of three components organised into an inner binary ($M_{1}$,$M_{2}$) and a more distant outer tertiary ($M_{3}$) star. The LAMOST Medium-Resolution Spectroscopic Survey (LAMOST-MRS) has offered a great sample for the study of triple system populations. We used the Peak Amplitude Ratio (PAR) method to obtain the mass ratio ($q_\mathrm{{in}}$, $q_\mathrm{{out}}$) of a triple system from its normalised spectrum. By calculating Cross-Correlation Function (CCF), we determined the correlation between the mass ratio $q_\mathrm{{out}}$ ($M_{3}$/($M_{1}$+$M_{2}$)) and the amplitude ratio ($A_{3}$/($A_{1}$+$A_{2}$)). We derived $q_\mathrm{{in}}$ of $0.5-1.0$ and $q_\mathrm{{out}}$ between 0.2 and 0.8. By fitting a power-law function of the corrected $q_\mathrm{{in}}$ distribution, the $\gamma_\mathrm{{in}}$ are estimated to be $-0.654\pm2.915$, $4.304\pm1.125$ and $11.371\pm1.309$ for A, F and G type stars. The derived $\gamma_\mathrm{{in}}$-values increase as the mass decrease, indicating that less massive stars are more likely to have companion stars with similar masses. By fitting a power-law function of the corrected $q_\mathrm{{out}}$ distribution, the ${\gamma_\mathrm{{out}}}$ are estimated to be $-2.016\pm0.172$, $-1.962\pm0.853$ and $-1.238\pm0.141$ for G, F and A type stars, respectively. The ${\gamma_\mathrm{{out}}}$-values show a trend of growth toward lower primary star masses

Research Progress of Hydrogen Production by Methanol Reforming for Fuel Cell Power Generation

Proton exchange membrane fuel cells take advantages of high efficiency, no pollution and good fuel adaptability. The green energy network formed by combining fuel cells with reliable hydrogen production is an effective way to achieve carbon neutrality. It is expected to promote the technological research and upgrading of new energy vehicles, unmanned air vehicles, ships and other industries those use fuel cells as electricity and thermal power source. However, a safe and stable hydrogen supply technology is a major bottleneck limiting the development of fuel cell power generation applications in mobile scenarios. Hydrogen production by in-situ methanol reforming is hopeful to make a breakthrough in mobile hydrogen source technology based on fuel cell. In this paper, the research progress of methanol reforming hydrogen production, the research progress of reactors for methanol reforming hydrogen production and the application of methanol reforming fuel cell power generation system were reviewed to provide reference and guidance for promoting the commercial development and application of methanol reforming fuel cell in the field of new energy

Study on optical fiber multi-parameter sensor

Based on the principle of fiber Bragg grating detection,an optical fiber sensor for detecting wind speed and temperature and humidity in underground space was designed.The designed optical fiber wind speed sensor was based on the thermal flow detection method,which has high sensitivity to low wind speed.For the speed rising from 0 to 0.5 m/s,the wavelength variation is about 800 pm.For the demodulator with sensitivity of 1 pm,the speed resolution is 0.7 mm/s.Fiber optic humidity sensor was fabricated by uniform surface coating of FBG element in polyimide solution,and detection sensitivity of 4.2 pm/% RH was achieved with accuracy less than ± 3% RH

A Miniaturized High-Gain Router Antenna Pair for 2.4 GHz and 5.0 GHz Frequency Bands

In this paper, we propose a printed circuit board (PCB)-based planar antenna pair, operating at 2.4 GHz and 5.0 GHz frequency bands, respectively, for dual-band routers. The antennas are both rectangular and consist of twisted radiating elements and microstrips etched on an FR4 dielectric substrate. Etching slots on the radiating elements and adjusting the serpentine microstrips influence surface current distribution and therefore effectively reduce antenna size and enhance antenna gain. The proposed antenna features a compact size compared to general router antennas and demonstrates high gain characteristics compared to dipole antennas. In the 2.3–2.5 GHz band, the simulated S11 of the 2.4 GHz antenna was lower than −10 dB, while the gain was 3.9 dBi at 2.4 GHz. In the 5.1–5.9 GHz band, the simulated S11 of the 5.0 GHz antenna was lower than −10 dB, and the gain was greater than 4.8 dBi. The proposed antenna has potential for application to router antennas

Prognostic and therapeutic implications of iron-related cell death pathways in acute myeloid leukemia

Acute myeloid leukemia (AML) is a blood cancer that is diverse in terms of its molecular abnormalities and clinical outcomes. Iron homeostasis and cell death pathways play crucial roles in cancer pathogenesis, including AML. The objective of this study was to examine the clinical significance of genes involved in iron-related cell death and apoptotic pathways in AML, with the intention of providing insights that could have prognostic implications and facilitate the development of targeted therapeutic interventions. Gene expression profiles, clinical information, and molecular alterations were integrated from multiple datasets, including TCGA-LAML and GSE71014. Our analysis identified specific molecular subtypes of acute myeloid leukemia (AML) displaying varying outcomes, patterns of immune cell infiltration, and profiles of drug sensitivity for targeted therapies based on the expression of genes involved in iron-related apoptotic and cell death pathways. We further developed a risk model based on four genes, which demonstrated promising prognostic value in both the training and validation cohorts, indicating the potential of this model for clinical decision-making and risk stratification in AML. Subsequently, Western blot analysis showed that the expression levels of C-Myc and CyclinD1 were significantly reduced after CD4 expression levels were knocked down. The findings underscore the potential of iron-related cell death pathways as prognostic biomarkers and therapeutic targets in AML, paving the way for further research aimed at understanding the molecular mechanisms underlying the correlation between iron balance, apoptosis regulation, and immune modulation in the bone marrow microenvironment

Comprehensive RNA-seq reveals molecular changes in kidney malignancy among people living with HIV

To heighten the awareness of kidney malignancy in patients with HIV infection to facilitate the early diagnosis of kidney cancer, the differentially expressed mRNAs were analyzed in this malignant tumor using RNA sequencing. We identified 2,962 protein-coding transcripts in HIV-associated kidney cancer. KISS1R, CAIX, and NPTX2 mRNA expression levels were specifically increased in HIV-associated kidney cancer while UMOD and TMEM213 mRNA were decreased in most cases based on real-time PCR analyses. These findings were similar to those noted for the general population with renal cell carcinoma. Immunohistochemical staining analysis also showed that a total of 18 malignant kidney cases among the people living with HIV (PLWH) exhibited positive staining for KISS1R and CAIX. Pathway analysis of the differentially expressed mRNAs in HIV-associated kidney cancer revealed that several key pathways were involved, including vascular endothelial growth factor-activated receptor activity, IgG binding, and lipopolysaccharide receptor activity. Altogether, our findings reveal the identified molecular changes in kidney malignancy, which may offer a helpful explanation for cancer progression and open up new therapeutic avenues that may decrease mortality after a cancer diagnosis among PLWH.</p