Partially Penalized Immersed Finite Element Methods for Elliptic Interface Problems

This article presents new immersed finite element (IFE) methods for solving the popular second order elliptic interface problems on structured Cartesian meshes even if the involved interfaces have nontrivial geometries. These IFE methods contain extra stabilization terms introduced only at interface edges for penalizing the discontinuity in IFE functions. With the enhanced stability due to the added penalty, not only these IFE methods can be proven to have the optimal convergence rate in the H1-norm provided that the exact solution has sufficient regularity, but also numerical results indicate that their convergence rates in both the H1-norm and the L2-norm do not deteriorate when the mesh becomes finer which is a shortcoming of the classic IFE methods in some situations. Trace inequalities are established for both linear and bilinear IFE functions that are not only critical for the error analysis of these new IFE methods, but also are of a great potential to be useful in error analysis for other IFE methods

Control of Soybean Aphids with Super Low-Dose Spraying: Efficacy and Labor Savings

The soybean aphid (Aphis glycines Mats.) is a major insect pest in soybean production areas, with annual occurrences causing serious damage to the soybean crops. The purpose of this experiment was to compare the control effect on soybean aphid and working efficacy of two methods of spraying with Dimethoate, namely, super-low volume spraying and conventional volume spraying, carried on the back with a manual compression operation. The results obtained are as follows.Originating text in Chinese.Citation: Li, Yong, Lin, Peili, Liu, Yanping. (1989). Control of Soybean Aphids with Super Low-Dose Spraying: Efficacy and Labor Savings. Agricultural Sciences [in Heilongjiang Province], 1, 34-35

Site-specific relapse pattern of the triple negative tumors in Chinese breast cancer patients

BACKGROUND: It has been reported that triple negative phenotype is characterized by aggressive clinical history in Western breast cancer patients, however its pattern of metastatic spread had never been reported in the Chinese population. Considering racial disparities, we sought to analyze the spread pattern for different sites of first recurrence in Chinese triple negative breast cancers. METHODS: A retrospective study of 1662 patients was carried out from a large database of breast cancer patients undergoing surgery between January 1, 2000 and March 31, 2004 at the Cancer Hospital, Fudan University, Shanghai, China. Survival curves were generated using the Kaplan-Meier method and annual relapse hazards were estimated by the hazard function. RESULTS: We found a statistically significant difference in relapse-free survival (RFS) for locoregional and visceral recurrence (P = 0.007 and P = 0.025, respectively) among the triple negative, ERBB2+ and HR+/ERBB2- subgroups in univariate analysis. In the multivariate Cox proportional hazards regression analysis, RFS for either locoregional or visceral relapse in the triple negative category was inferior to that in HR+/ERBB2- patients (P = 0.027 and P = 0.005, respectively), but comparable to that in ERBB2+ women (both P >0.05). Furthermore, the early relapse peak appeared later in the triple negative group than that in the ERBB2+ counterpart for both locoregional and visceral relapse. On the other hand, when compared with triple negative breast cancers, a significantly lower risk of developing bone relapse was discerned for ERBB2+ women (P = 0.048; HR = 0.384, 95% CI 0.148-0.991), with the borderline significance for HR+/ERBB2- breast cancers (P = 0.058; HR = 0.479, 95% CI 0.224-1.025). In terms of bone metastasis, the hazard rate remained higher for the triple negative category than that for the ERBB2+ subtype. CONCLUSION: Based on the site-specific spread pattern in different subgroups, the triple negative category of breast cancers in the Chinese population exhibits a different pattern of relapse, which indicates that different organotropism may be due to the different intrinsic subtypes. A better knowledge of the triple negative category is warranted for efficacious systemic regimens to decrease and/or delay the relapse hazard

Graduate Recital: Yanping Lin

Kemp Recital HallMarch 25, 2012Sunday Evening7: 00 p.m

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory responses. The functional significance of chromatin in the cytoplasm is unclear. Here we show that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS-STING (cyclic GMP-AMP synthase linked to stimulator of interferon genes) pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer. The cytoplasmic chromatin-cGAS-STING pathway promotes the senescence-associated secretory phenotype in primary human cells and in mice. Mice deficient in STING show impaired immuno-surveillance of oncogenic RAS and reduced tissue inflammation upon ionizing radiation. Furthermore, this pathway is activated in cancer cells, and correlates with pro-inflammatory gene expression in human cancers. Overall, our findings indicate that genomic DNA serves as a reservoir to initiate a pro-inflammatory pathway in the cytoplasm in senescence and cancer. Targeting the cytoplasmic chromatin-mediated pathway may hold promise in treating inflammation-related disorders