Dynamic Epistasis under Varying Environmental Perturbations

Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current knowledge for epistatic dynamics under multiple conditions is limited by the technological difficulties in experimentally screening epistatic relations among genes. We explored this issue by applying flux balance analysis to simulate epistatic landscapes under various environmental perturbations. Specifically, we looked at gene-gene epistatic interactions, where the mutations were assumed to occur in different genes. We predicted that epistasis tends to become more positive from glucose-abundant to nutrient-limiting conditions, indicating that selection might be less effective in removing deleterious mutations in the latter. We also observed a stable core of epistatic interactions in all tested conditions, as well as many epistatic interactions unique to each condition. Interestingly, genes in the stable epistatic interaction network are directly linked to most other genes whereas genes with condition-specific epistasis form a scale-free network. Furthermore, genes with stable epistasis tend to have similar evolutionary rates, whereas this co-evolving relationship does not hold for genes with condition-specific epistasis. Our findings provide a novel genome-wide picture about epistatic dynamics under environmental perturbations.Comment: 22 pages, 9 figure

Field-dependent quantum nucleation of antiferromagnetic bubbles

The phenomenon of quantum nucleation is studied in a nanometer-scale antiferromagnet with biaxial symmetry in the presence of a magnetic field at an arbitrary angle. Within the instanton approach, we calculate the dependence of the rate of quantum nucleation and the crossover temperature on the orientation and strength of the field for bulk solids and two-dimensional films of antiferromagnets, respectively. Our results show that the rate of quantum nucleation and the crossover temperature from thermal-to-quantum transitions depend on the orientation and strength of the field distinctly, which can be tested with the use of existing experimental techniques.Comment: 21 pages, 5 figures, Final version and accepted by Eur. Phys. J

Local Entanglement and quantum phase transition in spin models

Due to the phase interference of electromagnetic wave, one can recover the total image of one object from a small piece of holograph, which records the interference pattern of two laser light reflected from it. Similarly, the quantum superposition principle allows us to derive the global phase diagram of quantum spin models by investigating a proper local measurement. In the present paper, we study the two-site entanglement in the antifferomagnetic spin models with both spin-1/2 and 1. We show that its behaviors reveal some important information on the global properties and the quantum phase transition of these systems.Comment: 6 pages, 7 figure