Depolarization-activated potentiation of the T fiber synapse in the blue crab

The blue crab T fiber synapse, associated with the stretch receptor of the swimming leg, has a nonspiking presynaptic element that mediates tonic transmission. This synapse was isolated and a voltage clamp circuit was used to control the membrane potential at the release sites. The dependence of transmitter release on extracellular calcium, [Ca]o, was studied over a range of 2.5-40 mM. A power relationship of 2.7 was obtained between excitatory postsynaptic potential (EPSP) rate of rise and [Ca]o. Brief presynaptic depolarizing steps, 5-10 ms, presented at 0.5 Hz activated EPSP's of constant amplitude. Inserting a 300-ms pulse (conditioning pulse) between these test pulses potentiated the subsequent test EPSPs. This depolarization-activated potentiation (DAP) lasted for 10-20 s and decayed with a single exponential time course. The decay time course remained invariant with test pulse frequencies ranging from 0.11 to 1.1 Hz. The magnitude and decay time course of DAP were independent of the test pulse amplitudes. The magnitude of DAP was a function of conditioning pulse amplitudes. Large conditioning pulses activated large potentiations, whereas the decay time constants were not changed. The DAP is a Ca-dependent process. When the amplitude of conditioning pulses approached the Ca equilibrium potential, the magnitude of potentiation decreased. Repeated application of conditioning pulses, at 2-s intervals, did not produce additional potentiation beyond the level activated by the first conditioning pulse. Comparison of the conditioning EPSP waveforms activated repetitively indicated that potentiation lasted transiently, 100 ms, during a prolonged release. Possible mechanisms of the potentiation are discussed in light of these new findings.The blue crab T fiber synapse, associated with the stretch receptor of the swimming leg, has a nonspiking presynaptic element that mediates tonic transmission. This synapse was isolated and a voltage clamp circuit was used to control the membrane potential at the release sites. The dependence of transmitter release on extracellular calcium, [Ca]o, was studied over a range of 2.5-40 mM. A power relationship of 2.7 was obtained between excitatory postsynaptic potential (EPSP) rate of rise and [Ca]o. Brief presynaptic depolarizing steps, 5-10 ms, presented at 0.5 Hz activated EPSP's of constant amplitude. Inserting a 300-ms pulse (conditioning pulse) between these test pulses potentiated the subsequent test EPSPs. This depolarization-activated potentiation (DAP) lasted for 10-20 s and decayed with a single exponential time course. The decay time course remained invariant with test pulse frequencies ranging from 0.11 to 1.1 Hz. The magnitude and decay time course of DAP were independent of the test pulse amplitudes. The magnitude of DAP was a function of conditioning pulse amplitudes. Large conditioning pulses activated large potentiations, whereas the decay time constants were not changed. The DAP is a Ca-dependent process. When the amplitude of conditioning pulses approached the Ca equilibrium potential, the magnitude of potentiation decreased. Repeated application of conditioning pulses, at 2-s intervals, did not produce additional potentiation beyond the level activated by the first conditioning pulse. Comparison of the conditioning EPSP waveforms activated repetitively indicated that potentiation lasted transiently, 100 ms, during a prolonged release. Possible mechanisms of the potentiation are discussed in light of these new findings.NS-07942 - NINDS NIH HHS; NS-13742 - NINDS NIH HH

Binding energies of hydrogen-like impurities in a semiconductor in intense terahertz laser fields

A detailed theoretical study is presented for the influence of linearly polarised intense terahertz (THz) laser radiation on energy states of hydrogen-like impurities in semiconductors. The dependence of the binding energy for 1s and 2p states on intensity and frequency of the THz radiation has been examined.Comment: 14 pages, 4 figure

Axisymmetric Dynamic Response of Spherical and Cylindrical Shells

Axisymmetric dynamic response of spherical and cylindrical shell

Directed percolation near a wall

Series expansion methods are used to study directed bond percolation clusters on the square lattice whose lateral growth is restricted by a wall parallel to the growth direction. The percolation threshold $p_c$ is found to be the same as that for the bulk. However the values of the critical exponents for the percolation probability and mean cluster size are quite different from those for the bulk and are estimated by $\beta_1 = 0.7338 \pm 0.0001$ and $\gamma_1 = 1.8207 \pm 0.0004$ respectively. On the other hand the exponent $\Delta_1=\beta_1 +\gamma_1$ characterising the scale of the cluster size distribution is found to be unchanged by the presence of the wall. The parallel connectedness length, which is the scale for the cluster length distribution, has an exponent which we estimate to be $\nu_{1\parallel} = 1.7337 \pm 0.0004$ and is also unchanged. The exponent $\tau_1$ of the mean cluster length is related to $\beta_1$ and $\nu_{1\parallel}$ by the scaling relation $\nu_{1\parallel} = \beta_1 + \tau_1$ and using the above estimates yields $\tau_1 = 1$ to within the accuracy of our results. We conjecture that this value of $\tau_1$ is exact and further support for the conjecture is provided by the direct series expansion estimate $\tau_1= 1.0002 \pm 0.0003$.Comment: 12pages LaTeX, ioplppt.sty, to appear in J. Phys.

Unusual Tunneling Characteristics of Double-quantum-well Heterostructures

We report tunneling phenomena in double In$_{0.53}$Ga$_{0.47}$As quantum-well structures that are at odds with the conventional parallel-momentum-conserving picture of tunneling between two-dimensional systems. We found that the tunneling current was mostly determined by the correlation between the emitter and the state in one well, and not by that between those in both wells. Clear magnetic-field-dependent features were first observed before the main resonance, corresponding to tunneling channels into the Landau levels of the well near the emitter. These facts provide evidence of the violation of in-plane momentum conservation in two-dimensional systems.Comment: Submitted to ICPS-27 conference proceeding as a contributed pape

Formation time distribution of dark matter haloes: theories versus N-body simulations

This paper uses numerical simulations to test the formation time distribution of dark matter haloes predicted by the analytic excursion set approaches. The formation time distribution is closely linked to the conditional mass function and this test is therefore an indirect probe of this distribution. The excursion set models tested are the extended Press-Schechter (EPS) model, the ellipsoidal collapse (EC) model, and the non-spherical collapse boundary (NCB) model. Three sets of simulations (6 realizations) have been used to investigate the halo formation time distribution for halo masses ranging from dwarf-galaxy like haloes ($M=10^{-3} M_*$, where $M_*$ is the characteristic non-linear mass scale) to massive haloes of $M=8.7 M_*$. None of the models can match the simulation results at both high and low redshift. In particular, dark matter haloes formed generally earlier in our simulations than predicted by the EPS model. This discrepancy might help explain why semi-analytic models of galaxy formation, based on EPS merger trees, under-predict the number of high redshift galaxies compared with recent observations.Comment: 7 pages, 5 figures, accepted for publication in MNRA

Two-dimensional matrix algorithm using detrended fluctuation analysis to distinguish Burkitt and diffuse large B-cell lymphoma

Copyright © 2012 Rong-Guan Yeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.A detrended fluctuation analysis (DFA) method is applied to image analysis. The 2-dimensional (2D) DFA algorithms is proposed for recharacterizing images of lymph sections. Due to Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL), there is a significant different 5-year survival rates after multiagent chemotherapy. Therefore, distinguishing the difference between BL and DLBCL is very important. In this study, eighteen BL images were classified as group A, which have one to five cytogenetic changes. Ten BL images were classified as group B, which have more than five cytogenetic changes. Both groups A and B BLs are aggressive lymphomas, which grow very fast and require more intensive chemotherapy. Finally, ten DLBCL images were classified as group C. The short-term correlation exponent α1 values of DFA of groups A, B, and C were 0.370 ± 0.033, 0.382 ± 0.022, and 0.435 ± 0.053, respectively. It was found that α1 value of BL image was significantly lower (P < 0.05) than DLBCL. However, there is no difference between the groups A and B BLs. Hence, it can be concluded that α1 value based on DFA statistics concept can clearly distinguish BL and DLBCL image.National Science Council (NSC) of Taiwan the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan (also sponsored by National Science Council)

Photon Echoes Produced by Switching Electric Fields

We demonstrate photon echoes in Eu$^{3+}$:Y$_{2}$SiO$_{5}$ by controlling the inhomogeneous broadening of the Eu$^{3+}$ $^{7}$F$_{0}\leftrightarrow^{5}$D$_{0}$ optical transition. This transition has a linear Stark shift and we induce inhomogeneous broadening by applying an external electric field gradient. After optical excitation, reversing the polarity of the field rephases the ensemble, resulting in a photon echo. This is the first demonstration of such a photon echo and its application as a quantum memory is discussed.Comment: improved introduction, including theoretical outline of the relvant quantum memory proposa

Further development of a method for computing three-dimensional subsonic viscous flows in turbofan lobe mixers

Procedure for computing subsonic, turbulent flow in turbofan lobe mixers was extended to allow consideration of flow fields in which a swirl component of velocity may be present. Additional, an optional k-lambda turbulence model was added to the procedure. The method of specifying the initial flow field was also modified, allowing parametric specification or radial secondary flow velocities, and making it possible to consider initial flow fields which have significant inlet secondary flow vorticity. A series of example calculations was performed which demonstrate the various capabilities of the modified code. These calculations demonstrate the effects of initial secondary flows of various magnitudes, the effects of swirl, and the effects of turbulence model on the mixing process. The results of these calculations indicate that the initial secondary flows, presumed to be generated within the lobes, play a dominant role in the mixing process, and that the predicted results are relatively insensitive to the turbulence model used