Inverse regression for longitudinal data

Sliced inverse regression (Duan and Li [Ann. Statist. 19 (1991) 505-530], Li [J. Amer. Statist. Assoc. 86 (1991) 316-342]) is an appealing dimension reduction method for regression models with multivariate covariates. It has been extended by Ferr\'{e} and Yao [Statistics 37 (2003) 475-488, Statist. Sinica 15 (2005) 665-683] and Hsing and Ren [Ann. Statist. 37 (2009) 726-755] to functional covariates where the whole trajectories of random functional covariates are completely observed. The focus of this paper is to develop sliced inverse regression for intermittently and sparsely measured longitudinal covariates. We develop asymptotic theory for the new procedure and show, under some regularity conditions, that the estimated directions attain the optimal rate of convergence. Simulation studies and data analysis are also provided to demonstrate the performance of our method.Comment: Published in at http://dx.doi.org/10.1214/13-AOS1193 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org). With Correction

Neutron Density Distributions of Neutron-Rich Nuclei Studied with the Isobaric Yield Ratio Difference

The isobaric yield ratio difference (IBD) between two reactions of similar experimental setups is found to be sensitive to nuclear density differences between projectiles. In this article, the IBD probe is used to study the density variation in neutron-rich $^{48}$Ca. By adjusting diffuseness in the neutron density distribution, three different neutron density distributions of $^{48}$Ca are obtained. The yields of fragments in the 80$A$ MeV $^{40, 48}$Ca + $^{12}$C reactions are calculated by using a modified statistical abrasion-ablation model. It is found that the IBD results obtained from the prefragments are sensitive to the density distribution of the projectile, while the IBD results from the final fragments are less sensitive to the density distribution of the projectile.Comment: 3 figure

Slow in Motion but Smart in Learning and Memory: Behavioral Changes in Adult NR3A Knockout Mice

The expression of NMDA receptor subunit NR3A is high in the neonatal brain but low in adults. However, its functional role in the adult brain is obscure. Using wild-type (WT) and NR3A knockout (KO) mice, we show here that NR3A plays imperative roles in multiple behavioral functions in adults. NR3A deletion produced a slow locomotor phenotype with enhanced memory capacities. Hippocampal slices from juvenile and adult NR3A KO mice showed greater long-term potentiation (LTP) compared to WT slices. NR3A deletion resulted in increased expression and phosphorylation of calmodulin-dependent kinase II (CaMKII). CaMKII inhibition abrogated the enhanced LTP in NR3A KO slices. NR3A KO mice were also more sensitive to acute and chronic pain. These data reveal for the first time that NR3A, despite its low expression, plays several critical roles in behavioral activities in adults and may be a therapeutic target for modulating behaviors under normal and pathological conditions

Thermal performance of loop heat pipes with smooth and rough porous copper fiber sintered sheets

Smooth and rough porous copper fiber sintered sheets, employed here as wicks for loop heat pipes for the first time, were fabricated using a low-temperature solid-phase sintering method. The capillary performance of these porous copper fiber sintered sheets were analyzed and discussed. The influence of the surface morphology, filling ratio, and working fluid on the thermal resistance, evaporator wall temperature, and start-up time of the loop heat pipes were investigated. The results showed that the capillary pumping amount of working fluid for both smooth and rough porous copper fiber sintered sheets initially increases rapidly, and then gradually attains a stable state. The curve of the capillary pumping amount of working fluid can be described as a function that increases exponentially over time. When rough porous copper fiber sintered sheets are used as wicks and deionized water is used as the working fluid, the capillary pumping amount is maximized. Compared to smooth porous copper fiber sintered sheets, loop heat pipes with rough porous copper fiber sintered sheets exhibit a shorter start-up time, lower thermal resistance, and lower evaporator wall temperature. For a filling ratio in the range of 15–45%, loop heat pipes with rough porous copper fiber sintered sheets and a 30% filling ratio show lower thermal resistance and a lower evaporator wall temperature. Ultimately, the use of deionized water as the working fluid with a 30% filling ratio enables loop heat pipes with rough porous copper fiber sintered sheets to be stably operated at a heat load of 200 W