DESAIN FASADE CERDAS UNTUK SEKOLAH DASAR DI SURABAYA TIMUR

Pendidikan memainkan peran besar untuk pengembangan kreativitas kota serta bangsa. Di sisi lain, fasilitas pendidikan dasar seringkali tidak dirancang mempertimbangkan langkah-langkah estetika. Untuk menghasilkan ruang pendidikan kreatif, salah satu strategi adalah elaborasi fasade. Fasad bangunan pendidikan dianalisis berdasarkan prinsip komposisi Ching (2008) dan kemudian modul fasad kreatif diusulkan dengan pertimbangan fungsional dan ekonomis. Façade diusulkan berdasarkan kegiatan belajar berbasis siswa dan pengajaran klasik dengan penggunaan LCD. Oleh karena itu, komposisi façade terdiri dari 30% area jendela dan 70% luas dinding. Sementara itu, bahan kaca cerdas terpilih untuk memfasilitasi pencahayaan untuk kegiatan siswa atau menghalangi pencahayaan tersebut itu untuk sesi presentasi LCD

Curvature model for nanoparticle size effects on peptide fibril stability and molecular dynamics simulation data

Nanostructured surfaces are widespread in nature and are being further developed in materials science. This makes them highly relevant for biomolecules, such as peptides. In this data article, we present a curvature model and molecular dynamics (MD) simulation data on the influence of nanoparticle size on the stability of amyloid peptide fibrils related to our research article entitled “Mechanistic insights into the size-dependent effects of nanoparticles on inhibiting and accelerating amyloid fibril formation” (John et al., 2022) [1]. We provide the code to perform MD simulations in GROMACS 4.5.7 software of arbitrarily chosen biomolecule oligomers adsorbed on a curved surface of chosen nanoparticle size. We also provide the simulation parameters and data for peptide oligomers of Aß40, NNFGAIL, GNNQQNY, and VQIYVK. The data provided allows researchers to further analyze our MD simulations and the curvature model allows for a better understanding of oligomeric structures on surfaces

Neutrophil Function in Elderly Patients Hospitalized with Community- Acquired Pneumonia

Background: Advanced age is associated with immunosenescence as well as increased risk for poor outcomes during episodes of community-acquired pneumonia (CAP). Data on neutrophil function in hospitalized elderly patients with CAP is lacking. In this study we compared neutrophil function in elderly and non-elderly hospitalized patients with CAP. Methods: Prospective study of healthy controls (HC) and patients hospitalized with CAP nonelderly (NE-CAP) and elderly (E-CAP). Blood samples were obtained on the day of hospitalization. The following neutrophil functional assays were performed: degranulation of secretory vesicles (CD35), degranulation of specific granules (CD66b), phagocytosis, and hydrogen peroxide (H2O2) production. The Mann-Whitney U-test was used to compare differences in neutrophil function. Results: A total of 12 HC, 28 NE-CAP, and 12 E-CAP were evaluated. There were no significant differences between NE-CAP and E-CAP patients in regard to CD35 expression (p=0.465), CD66b expression (p=0.601), phagocytosis (p=0.654), or H2O2 production (p=0.541) Conclusions: We failed to demonstrate any significant difference in neutrophil function in nonelderly versus elderly patients hospitalized with CAP in relation to membrane expression of CD35 and CD66b, phagocytosis, and respiratory burst. Abnormal neutrophil function is unlikely to be an important component of the immunosenescence described in elderly patients with CAP

Neutrophil function in elderly patients hospitalized with community-acquired pneumonia.

Background: Advanced age is associated with immunosenescence as well as increased risk for poor outcomes during episodes of community-acquired pneumonia (CAP). Data on neutrophil function in hospitalized elderly patients with CAP is lacking. In this study we compared neutrophil function in elderly and non-elderly hospitalized patients with CAP. Methods: Prospective study of healthy controls (HC) and patients hospitalized with CAP nonelderly (NE-CAP) and elderly (E-CAP). Blood samples were obtained on the day of hospitalization. The following neutrophil functional assays were performed: degranulation of secretory vesicles (CD35), degranulation of specific granules (CD66b), phagocytosis, and hydrogen peroxide (H2O2) production. The Mann-Whitney U-test was used to compare differences in neutrophil function. Results: A total of 12 HC, 28 NE-CAP, and 12 E-CAP were evaluated. There were no significant differences between NE-CAP and E-CAP patients in regard to CD35 expression (p=0.465), CD66b expression (p=0.601), phagocytosis (p=0.654), or H2O2 production (p=0.541) Conclusions: We failed to demonstrate any significant difference in neutrophil function in nonelderly versus elderly patients hospitalized with CAP in relation to membrane expression of CD35 and CD66b, phagocytosis, and respiratory burst. Abnormal neutrophil function is unlikely to be an important component of the immunosenescence described in elderly patients with CAP

Detección de anomalías en grandes volúmenes de datos

El desarrollo de la era digital ha traído como consecuencia un incremento considerable de los volúmenes de datos. A estos grandes volúmenes de datos se les ha denominado big data ya que exceden la capacidad de procesamiento de sistemas de bases de datos convencionales. Diversos sectores consideran varias oportunidades y aplicaciones en la detección de anomalías en problemas de big data.  Para realizar este tipo de análisis puede resultar muy útil el empleo de técnicas de minería de datos porque permiten extraer patrones y relaciones desde grandes cantidades de datos. El procesamiento y análisis de estos volúmenes de datos, necesitan de herramientas capaces de procesarlos como Apache Spark y Hadoop. Estas herramientas no cuentan con algoritmos específicos para la detección de anomalías. El objetivo del trabajo es presentar un nuevo algoritmo para la detección de anomalías basado en vecindad para de problemas big data. A partir de un estudio comparativo se seleccionó el algoritmo KNNW por sus resultados, con el fin de diseñar una variante big data. La implementación del algoritmo big data se realizó en la herramienta Apache Spark, utilizando el paradigma de programación paralela MapReduce. Posteriormente se realizaron diferentes experimentos para analizar el comportamiento del algoritmo con distintas configuraciones. Dentro de los experimentos se compararon los tiempos de ejecución y calidad de los resultados entre la variante secuencial y la variante big data. La variante big data obtuvo mejores resultados con diferencia significativa. Logrando que la variante big data, KNNW-BigData, pueda procesar grandes volúmenes de datos

Reconstructing genome evolution in historic samples of the Irish potato famine pathogen

Responsible for the Irish potato famine of 1845–49, the oomycete pathogen Phytophthora infestans caused persistent, devastating outbreaks of potato late blight across Europe in the 19th century. Despite continued interest in the history and spread of the pathogen, the genome of the famine-era strain remains entirely unknown. Here we characterize temporal genomic changes in introduced P. infestans. We shotgun sequence five 19th-century European strains from archival herbarium samples—including the oldest known European specimen, collected in 1845 from the first reported source of introduction. We then compare their genomes to those of extant isolates. We report multiple distinct genotypes in historical Europe and a suite of infection-related genes different from modern strains. At virulence-related loci, several now-ubiquitous genotypes were absent from the historical gene pool. At least one of these genotypes encodes a virulent phenotype in modern strains, which helps explain the 20th century’s episodic replacements of European P. infestans lineages