Aharonov-Bohm interference in the presence of metallic mesoscopic cylinders

This work studies the interference of electrons in the presence of a line of magnetic flux surrounded by a normal-conducting mesoscopic cylinder at low temperature. It is found that, while there is a supplementary phase contribution from each electron of the mesoscopic cylinder, the sum of these individual supplementary phases is equal to zero, so that the presence of a normal-conducting mesoscopic ring at low temperature does not change the Aharonov-Bohm interference pattern of the incident electron. It is shown that it is not possible to ascertain by experimental observation that the shielding electrons have responded to the field of an incident electron, and at the same time to preserve the interference pattern of the incident electron. It is also shown that the measuring of the transient magnetic field in the region between the two paths of an electron interference experiment with an accuracy at least equal to the magnetic field of the incident electron generates a phase uncertainty which destroys the interference pattern.Comment: 15 pages, 5 Postscript figure

Sustainable land use in mountain regions under global change: synthesis across scales and disciplines

Mountain regions provide essential ecosystem goods and services (EGS) for both mountain dwellers and people living outside these areas. Global change endangers the capacity of mountain ecosystems to provide key services. The Mountland project focused on three case study regions in the Swiss Alps and aimed to propose land-use practices and alternative policy solutions to ensure the provision of key EGS under climate and land-use changes. We summarized and synthesized the results of the project and provide insights into the ecological, socioeconomic, and political processes relevant for analyzing global change impacts on a European mountain region. In Mountland, an integrative approach was applied, combining methods from economics and the political and natural sciences to analyze ecosystem functioning from a holistic human-environment system perspective. In general, surveys, experiments, and model results revealed that climate and socioeconomic changes are likely to increase the vulnerability of the EGS analyzed. We regard the following key characteristics of coupled human-environment systems as central to our case study areas in mountain regions: thresholds, heterogeneity, trade-offs, and feedback. Our results suggest that the institutional framework should be strengthened in a way that better addresses these characteristics, allowing for (1) more integrative approaches, (2) a more network-oriented management and steering of political processes that integrate local stakeholders, and (3) enhanced capacity building to decrease the identified vulnerability as central elements in the policy process. Further, to maintain and support the future provision of EGS in mountain regions, policy making should also focus on project-oriented, cross-sectoral policies and spatial planning as a coordination instrument for land use in general

Dataset on the activation of Muller cells through macrophages upon hypoxia in the retina

The dataset presented in this article complements the article entitled “Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells” (C. Nürnberg, N. Kociok, C. Brockmann, T. Lischke, S. Crespo-Garcia, N. Reichhart, S. Wolf, R. Baumgrass, S.A. Eming, S. Beer- Hammer, and A.M. Joussen). This complementary dataset provides further insight into the experimental validation of the VEGFfl/fl LysMCre (here named VEGFmcko) knockout model used in the main article through genomic and quantitative Real-Time PCR in various murine tissues as well as additional flow cytometry data and immunohistochemical stainings. By providing these data, we aim to enable researcher to reproduce and critically analyze our data

Improving mentalizing deficits in older age with region-specific transcranial direct current stimulation.

Older adults have difficulties to detect the intentions, thoughts, and feelings of others, indicating an age-associated decline of socio-cognitive abilities that are known as "mentalizing". These deficits in mental state recognition are driven by neurofunctional alterations in brain regions that are implicated in mentalizing, such as the right temporo-parietal junction (rTPJ) and the dorso-medial prefrontal cortex (dmPFC). We tested whether focal transcranial current stimulation (tDCS) of the rTPJ and dmPFC has the potential to eliminate mentalizing deficits in older adults. Mentalizing deficits were assessed with a novel mindreading task that required the recognition of mental states in child faces. Older adults (n = 60) performed worse than younger adults (n = 30) on the mindreading task, indicating age-dependent deficits in mental state recognition. These mentalizing deficits were ameliorated in older adults who received sham-controlled andodal tDCS over the rTPJ (n = 30) but remained unchanged in older adults who received sham-controlled andodal tDCS over the dmPFC (n = 30). We, thus, showed for the first time that anodal tDCS over the rTPJ has the potential to remediate age-dependent mentalizing deficits in a region-specific way. This provides a rationale for exploring stimulation-based interventions targeting mentalizing deficits in older age. [Abstract copyright: © 2024. The Author(s).

Oxytocin receptor gene polymorphisms are associated with human directed social behavior in dogs (Canis familiaris)

The oxytocin system has a crucial role in human sociality; several results prove that polymorphisms of the oxytocin receptor gene are related to complex social behaviors in humans. Dogs' parallel evolution with humans and their adaptation to the human environment has made them a useful species to model human social interactions. Previous research indicates that dogs are eligible models for behavioral genetic research, as well. Based on these previous findings, our research investigated associations between human directed social behaviors and two newly described (−212AG, 19131AG) and one known (rs8679684) single nucleotide polymorphisms (SNPs) in the regulatory regions (5′ and 3′ UTR) of the oxytocin receptor gene in German Shepherd (N = 104) and Border Collie (N = 103) dogs. Dogs' behavior traits have been estimated in a newly developed test series consisting of five episodes: Greeting by a stranger, Separation from the owner, Problem solving, Threatening approach, Hiding of the owner. Buccal samples were collected and DNA was isolated using standard protocols. SNPs in the 3′ and 5′ UTR regions were analyzed by polymerase chain reaction based techniques followed by subsequent electrophoresis analysis. The gene–behavior association analysis suggests that oxytocin receptor gene polymorphisms have an impact in both breeds on (i) proximity seeking towards an unfamiliar person, as well as their owner, and on (ii) how friendly dogs behave towards strangers, although the mediating molecular regulatory mechanisms are yet unknown. Based on these results, we conclude that similarly to humans, the social behavior of dogs towards humans is influenced by the oxytocin system

Evidence for anisotropic final state interactions in the two-photon ionization of rare gases

Synopsis Anisotropic final state interactions are exhibited most clearly in the angular momentum dependent position of Cooper minima in the photoionization partial cross section and angular distribution asymmetry parameter. We show first indication of this effect in two-photon ionization of rare gases

ARIADNE: A scientific navigator to find your way through the resource labyrinth of psychological sciences

Performing high-quality research is a challenging endeavor, especially for early career researchers, in many fields of psychological science. Most research is characterized by experiential learning, which can be time-consuming, error-prone, and frustrating. Although most institutions provide selected resources to help researchers with their projects, these resources are often expensive, spread out, hard to find, and difficult to compare with one another in terms of reliability, validity, usability, and practicability. A comprehensive overview of resources that are useful for researchers in psychological science is missing. To address this issue, we created ARIADNE: a living and interactive resource navigator that helps to use and search a dynamically updated database of resources (https://igor-biodgps.github.io/ARIADNE). In this tutorial, we aim to guide researchers through a standard research project using ARIADNE along the way. The open-access database covers a growing list of resources useful for each step of a research project, from the planning and designing of a study, over the collection and analysis of the data, to the writing and disseminating of the findings. We provide (a) a step-by-step guide on how to perform a research project (in the fields of biological psychology and neuroscience as a case example but with broad application to neighboring fields) and (b) an overview of resources that are useful at different project steps. By explicitly highlighting open-access and open-source resources, we level the playing field for researchers from underprivileged countries or institutions, thereby facilitating open, fair, and reproducible research in the psychological sciences

ICOS regulates the generation and function of human CD4+ Treg in a CTLA-4 dependent manner

Inducible co-stimulator (ICOS) is a member of CD28/Cytotoxic T-lymphocyte Antigen-4 (CTLA-4) family and broadly expressed in activated CD4+ T cells and induced regulatory CD4+ T cells (CD4+ iTreg). ICOS-related signal pathway could be activated by the interaction between ICOS and its ligand (ICOSL). In our previous work, we established a cost-effective system to generate a novel human allo-antigen specific CD4hi Treg by co-culturing their naïve precursors with allogeneic CD40-activated B cells in vitro. Here we investigate the role of ICOS in the generation and function of CD4hi Treg by interrupting ICOS-ICOSL interaction with ICOS-Ig. It is found that blockade of ICOS-ICOSL interaction impairs the induction and expansion of CD4hi Treg induced by allogeneic CD40-activated B cells. More importantly, CD4hi Treg induced with the addition of ICOS-Ig exhibits decreased suppressive capacity on alloantigen-specific responses. Dysfunction of CD4hi Treg induced with ICOS-Ig is accompanied with its decreased exocytosis and surface CTLA-4 expression. Through inhibiting endocytosis with E64 and pepstatin A, surface CTLA-4 expression and suppressive functions of induced CD4hi Treg could be partly reversed. Conclusively, our results demonstrate the beneficial role of ICOS-ICOSL signal pathway in the generation and function of CD4hi Treg and uncover a novel relationship between ICOS and CTLA-4. © 2013 zheng et al.published_or_final_versio

Men's empathy toward children's emotions across the transition to fatherhood.

We investigated whether men's affective and cognitive empathy toward children's emotions changes across the transition to fatherhood. Specifically, we were interested in whether empathy increases with fathering experience. In two preregistered online studies (N = 1,046, primarily from the United Kingdom and the United States), participants' task was to rate their affective responses to emotional pictures of children (affective empathy) and to recognize children's emotions from pictures of the eye area (cognitive empathy). In Study 1 (N = 530), we compared childless men, expecting fathers, and fathers. Expecting fathers displayed greater affective empathy toward children than childless men, but they did not differ significantly from fathers. Unexpectedly, fathers exhibited lower cognitive empathy than expecting fathers. Study 2 (N = 516) extended these findings by investigating the impact of different levels of fathering experience among first-time fathers and those with prior parenting experience. Fathers of infants showed more affective empathy than childless men, regardless of prior parenting experience. Fathers with older children had lower cognitive empathy compared to childless men and fathers with infants. These results suggest that expecting fathers and fathers with a new infant may exhibit increased affective empathy to children's emotions. More experienced fathers and fathers of older children may have become accustomed to childcare, necessitating less intensive engagement to child signals. Future longitudinal studies are needed to determine whether empathy toward children's emotions shows within-person fluctuations during the transition to fatherhood instead of steadily increasing. (PsycInfo Database Record (c) 2024 APA, all rights reserved).Education and Child Studie