23,314 research outputs found

    Overview of permanent-magnet brushless drives for electric and hybrid electric vehicles

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    With ever-increasing concerns on our environment, there is a fast growing interest in electric vehicles (EVs) and hybrid EVs (HEVs) from automakers, governments, and customers. As electric drives are the core of both EVs and HEVs, it is a pressing need for researchers to develop advanced electric-drive systems. In this paper, an overview of permanent-magnet (PM) brushless (BL) drives for EVs and HEVs is presented, with emphasis on machine topologies, drive operations, and control strategies. Then, three major research directions of the PM BL drive systems are elaborated, namely, the magnetic-geared outer-rotor PM BL drive system, the PM BL integrated starter-generator system, and the PM BL electric variable-transmission system. © 2008 IEEE.published_or_final_versio

    Cancer gene therapy targeting angiogenesis: An updated review

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    Since the relationship between angiogenesis and tumor growth was established by Folkman in 1971, scientists have made efforts exploring the possibilities in treating cancer by targeting angiogenesis. Inhibition of angiogenesis growth factors and administration of angiogenesis inhibitors are the basics of anti-angiogenesis therapy. Transfer of anti-angiogenesis genes has received attention recently not only because of the advancement of recombinant vectors, but also because of the localized and sustained expression of therapeutic gene product inside the tumor after gene transfer. This review provides the up-to-date information about the strategies and the vectors studied in the field of anti-angiogenesis cancer gene therapy. © 2006 The WJG Press. All rights reserved.published_or_final_versio

    Constructing power system restoration strategies

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    System restoration is an integral part of the overall defense system against catastrophic outages. The nature of system restoration problem involves status assessment, optimization of generation capability and load pickup. The optimization problem needs to take into numerous practical considerations and, therefore, it cannot be formulated as one single optimization problem. The other critical consideration for the development of decision support tools is its generality, i.e., the tools should be portable from a system to another with minimal customization. This presentation will provide a comprehensive methodology for construction of system restoration strategies. The strategy adopted by each power system differs, depending on the system characteristics and policies. A new method based on the concept of "generic restoration milestones" and "generic restoration actions" has been developed. A specific restoration strategy can be synthesized by a combination of the milestones and actions based on the actual system conditions. The decision support tool is expected to reduce the restoration time, thereby improving the system reliability.published_or_final_versionThe 6th International Conference on Electrical and Electroincs Engineering (ELECO 2009), Bursa, Turkey, 5-8 November 2009. In Proceedings of the International Conference on Electrical and Electronics Engineering, 2009, p. I8-I1

    Computation of milestones for decision support during system restoration

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    System restoration involves status assessment, optimization of generation capability, and load pickup. The optimization problem needs to take complex constraints into consideration, and therefore, it is not practical to formulate the problem as one single optimization problem. The other critical consideration for the development of decision support tools is its generality, i.e., the tools should be portable from a system to another with minimal customization. This paper reports a practical methodology for construction of system restoration strategies. The strategy adopted by each power system differs, depending on system characteristics and policies. A new method based on the concept of generic restoration milestones (GRMs) is proposed. A specific restoration strategy can be synthesized by a combination of GRMs based on the actual system conditions. The decision support tool is expected to reduce the restoration time, thereby improving system reliability. The proposed decision support tool has been validated with cases based on a simplified Western Electricity Coordinating Council (WECC) 200-Bus system and Hawaiian Electric Company system. © 2011 IEEE.published_or_final_versio

    Epidemiology of acute primary angle-closure glaucoma in the Hong Kong Chinese population: prospective study.

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    OBJECTIVES: To determine the incidence of acute primary angle-closure glaucoma in the Hong Kong Chinese population, and to identify risk factors for this condition. DESIGN: Prospective study. SETTING: University teaching hospital, Hong Kong. PARTICIPANTS: Patients with acute primary angle-closure glaucoma presenting between 1 March 1998 and 29 February 2000. MAIN OUTCOME MEASURES: Demographic data, presenting symptoms and signs, temporal details of the presentation, and precipitating factors. The crude regional incidence was calculated according to the Hong Kong population census of 1991 and the age-specific incidence was calculated. RESULTS: Seventy-two cases (72 eyes of 72 patients) of acute primary angle-closure glaucoma were recruited. The crude incidence was 10.4 per 100,000 per year in the population aged 30 years and older. Patients at higher risk of attacks were those aged 70 years or older (age-specific incidence, 58.7 per 100,000 per year) and females, who had a relative risk of 3.8 compared with males (95% confidence interval, 1.7-8.4). Only four (5.6%) patients had a positive family history of acute primary angle-closure glaucoma. Seventeen (23.6%) patients were noted to have an upper respiratory tract infection before the attack, and 25 (34.7%) patients had taken antitussive agents. There was a statistically significant inverse correlation between the monthly attack rate and the monthly rate of influenza (Spearman's rank correlation coefficient = -0.388; P=0.031). CONCLUSION: There is a high incidence of acute primary angle-closure glaucoma among Chinese residents of Hong Kong, with elderly females at highest risk. A significant proportion of patients reported upper respiratory tract infection or the use of antitussive medication prior to attacks.published_or_final_versio

    Comparison of hybrid-excitation fault-tolerant in-wheel motor drives for electric vehicles

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    Paper no. DS2-23Hybrid-excitation in-wheel motor drive receives the attractive merit for its fault-tolerant operation. This paper gives the performance comparison of three types of hybrid-excitation in-wheel motor drives in electric vehicles (EVs) for their fault-tolerant operations. By using finite-time element analysis, the torque output is utilized as the fault indicator to investigate the performances of each motor drive under normal, faulty, and remedial operations.published_or_final_versio

    Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae

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    Poster presentation - Theme 3: Development & stem cellsThe Sonic Hedgehog pathway plays important roles in mammalian inner ear development. Mutations of Shh, Smo and Gli3 lead to severe defects in mouse inner ear morphogenesis. However, knockout of Gli2 does not affect inner ear morphology or cochlear hair cell differentiation, suggesting that the Gli repressor function may be required for Hedgehog signaling during inner ear development. Sufu is a negative regulator of Hedgehog signaling and it functions to repress Gli activator and enhance Gli repressor ...postprin

    Transperineal endoscopic drainage of a presacral and paraspinal abscess

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