An Interesting Fitting of Quark Masses

In this note we show an empirical formula of quark masses, which is found by implementing a least squares fit. In this formula the measured QCD coupling is almost a "best fitting coupling".Comment: 5 pages, 2 figure

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways

Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of neurodevelopmental migratory pathways, possibly triggered by febrile seizures. This study aims to compare the proteomes of basal and dispersed granule cells in the hippocampus of eight MTLE patients with GCD to identify proteins that may mediate GCD in MTLE. Quantitative proteomics identified 1882 proteins, of which 29% were found in basal granule cells only, 17% in dispersed only and 54% in both samples. Bioinformatics analyses revealed upregulated proteins in dispersed samples were involved in developmental cellular migratory processes, including cytoskeletal remodelling, axon guidance and signalling by Ras homologous (Rho) family of GTPases (P<0.01). The expression of two Rho GTPases, RhoA and Rac1, was subsequently explored in immunohistochemical and in situ hybridisation studies involving eighteen MTLE cases with or without GCD, and three normal post mortem cases. In cases with GCD, most dispersed granule cells in the outer-granular and molecular layers have an elongated soma and bipolar processes, with intense RhoA immunolabelling at opposite poles of the cell soma, while most granule cells in the basal granule cell layer were devoid of RhoA. A higher density and percentage of cells expressing RhoA was observed in cases with GCD than without GCD (P<0.004). In GCD cases, the density and percentage of cells expressing RhoA was significantly higher in the inner molecular layer than granule cell layer (P<0.026), supporting proteomic findings. In situ hybridisation studies using probes against RHOA and RAC1 mRNAs revealed fine peri- and nuclear puncta in granule cells of all cases. The density of cells expressing RHOA mRNAs were significantly higher in the inner molecular layer of cases with GCD than without GCD(P=0.05). In summary, our study has found limited evidence for ongoing adult neurogenesis in the hippocampus of patients with MTLE, but evidence of differential dysmaturation between dispersed and basal granule cells has been demonstrated, and elevated expression of Rho GTPases in dispersed granule cells may contribute to the pathomechanisms underpinning GCD in MTLE

Design and Control of a Flight-Style AUV with Hovering Capability

The small flight-style Delphin AUV is designed to evaluate the performance of a long range survey AUV with the additional capability to hover and manoeuvre at slow speed. Delphin’s hull form is based on a scaled version of Autosub6000, and in addition to the main thruster and control surfaces at the rear of the vehicle, Delphin is equipped with four rim driven tunnel thrusters. In order to reduce the development cycle time, Delphin was designed to use commercial-off-the-shelf (COTS) sensors and thrusters interfaced to a standard PC motherboard running the control software within the MS Windows environment. To further simplify the development, the autonomy system uses the State-Flow Toolbox within the Matlab/Simulink environment. While the autonomy software is running, image processing routines are used for obstacle avoidance and target tracking, within the commercial Scorpion Vision software. This runs as a parallel thread and passes results to Matlab via the TCP/IP communication protocol. The COTS based development approach has proved effective. However, a powerful PC is required to effectively run Matlab and Simulink, and, due to the nature of the Windows environment, it is impossible to run the control in hard real-time. The autonomy system will be recoded to run under the Matlab Windows Real-Time Windows Target in the near future. Experimental results are used to demonstrating the performance and current capabilities of the vehicle are presented

Risk Spillovers in Oil-Related CDS, Stock and Credit Markets

This paper examines risk transmission and migration among six US measures of credit and market risk during the full period 2004-2011 period and the 2009-2011 recovery subperiod, with a focus on four sectors related to the highly volatile oil price. There are more long-run equilibrium risk relationships and short-run causal relationships among the four oil-related Credit Default Swaps (CDS) indexes, the (expected equity volatility) VIX index and the (swaption expected volatility) SMOVE index for the full period than for the recovery subperiod. The auto sector CDS spread is the most error-correcting in the long run and also leads in the risk discovery process in the short run. On the other hand, the CDS spread of the highly regulated, natural monopoly utility sector does not error correct. The four oil-related CDS spread indexes are responsive to VIX in the short- and long-run, while no index is sensitive to SMOVE which, in turn, unilaterally assembles risk migration from VIX. The 2007-2008 Great Recession seems to have led to “localization†and less migration of credit and market risk in the oil-related sectors.adjustments;MOVE;SMOVE;VIX;risk,;sectoral CDS

Enhanced Cluster Based Routing Protocol for MANETS

Mobile ad-hoc networks (MANETs) are a set of self organized wireless mobile nodes that works without any predefined infrastructure. For routing data in MANETs, the routing protocols relay on mobile wireless nodes. In general, any routing protocol performance suffers i) with resource constraints and ii) due to the mobility of the nodes. Due to existing routing challenges in MANETs clustering based protocols suffers frequently with cluster head failure problem, which degrades the cluster stability. This paper proposes, Enhanced CBRP, a schema to improve the cluster stability and in-turn improves the performance of traditional cluster based routing protocol (CBRP), by electing better cluster head using weighted clustering algorithm and considering some crucial routing challenges. Moreover, proposed protocol suggests a secondary cluster head for each cluster, to increase the stability of the cluster and implicitly the network infrastructure in case of sudden failure of cluster head.Comment: 6 page

Neutrinoless double-beta decay with three or four neutrino mixing

Considering the scheme with mixing of three neutrinos and a mass hierarchy that can accommodate the results of solar and atmospheric neutrino experiments, it is shown that the results of solar neutrino experiments imply a lower bound for the effective Majorana mass in neutrinoless double-beta decay, under the natural assumptions that massive neutrinos are Majorana particles and there are no unlikely fine-tuned cancellations among the contributions of the different neutrino masses. Considering the four-neutrino schemes that can accommodate also the results of the LSND experiment, it is shown that only one of them is compatible with the results of neutrinoless double-beta decay experiments and with the measurement of the abundances of primordial elements produced in Big-Bang Nucleosynthesis. It is shown that in this scheme, under the assumptions that massive neutrinos are Majorana particles and there are no cancellations among the contributions of the different neutrino masses, the results of the LSND experiment imply a lower bound for the effective Majorana mass in neutrinoless double-beta decay.Comment: 18 pages including 2 figures, RevTe

Cultural differences in intimacy: The influence of gender-role ideology and individualism-collectivism

Two studies examined emotional intimacy in European Canadian and Chinese Canadian dating relationships. Cultural differences in gender-role ideology and individualism–collectivism were hypothesized to differentially contribute to selfdisclosure and responsiveness, and in turn, intimacy. Study 1 revealed that Chinese Canadians’ lower intimacy relative to European Canadians was mediated by their greater gender-role traditionalism but not by their individualism or collectivism. Study 2 further linked greater gender-role traditionalism to lower self-disclosure, and in turn, lower intimacy. Results also revealed that Chinese Canadians’ lower intimacy mediated their lower relationship satisfaction and higher rate of relationship termination in Study 1, but that Chinese Canadians were not any more likely to terminate their relationships in Study 2

Leading-Order Actions of Goldstino Fields

This paper starts with a self-contained discussion of the so-called Akulov-Volkov action S_AV, which is traditionally taken to be the leading-order action of Goldstino field. Explicit expressions for S_AV and its chiral version S_AV^ch are presented. We then turn to the issue on how these actions are related to the leading-order action S_NL proposed in the newly proposed constrained superfield formalism. We show that S_NL may yield S_AV/S_AV^ch or a totally different action S_KS, depending on how the auxiliary field in the former is integrated out. However, S_KS and S_AV/S_AV^ch always yield the same S-matrix elements, as one would have expected from general considerations in quantum field theory.Comment: Minor changes, version to appear in European Physical Journal

Microheated substrates for patterning cells and controlling development

Here, we seek to control cellular development by devising a means through which cells can be subjected to a microheated environment in standard culture conditions. Numerous techniques have been devised for controlling cellular function and development via manipulation of surface environmental cues at the micro- and nanoscale. It is well understood that temperature plays a significant role in the rate of cellular activities, migratory behavior (thermotaxis), and in some cases, protein expression. Yet, the effects and possible utilization of micrometer-scale temperature fields in cell cultures have not been explored. Toward this end, two types of thermally isolated microheated substrates were designed and fabricated, one with standard backside etching beneath a dielectric film and another with a combination of surface and bulk micromachining and backside etching. The substrates were characterized with infrared microscopy, finite element modeling, scanning electron microscopy, stylus profilometry, and electrothermal calibrations. Neuron culture studies were conducted on these substrates to 1) examine the feasibility of using a microheated environment to achieve patterned cell growth and 2) selectively accelerate neural development on regions less than 100$mu m$wide. Results show that attached neurons, grown on microheated regions set at 37$~^circ C$, extended processes substantially faster than those incubated at 25$~^circ C$on the same substrate. Further, unattached neurons were positioned precisely along the length of the heater filament (operating at 45$~^circ C$) using free convection currents. These preliminary findings indicate that microheated substrates may be used to direct cellular development spatially in a practical manner.$hfillhbox[1414]

Low-temperature anomalous specific heat without tunneling modes: a simulation for a-Si with voids

Using empirical potential molecular dynamics we compute dynamical matrix eigenvalues and eigenvectors for a 4096 atom model of amorphous silicon and a set of models with voids of different size based on it. This information is then employed to study the localization properties of the low-energy vibrational states, calculate the specific heat C(T) and examine the low-temperature properties of our models usually attributed to the presence of tunneling states in amorphous silicon. The results of our calculations for C(T) and "excess specific heat bulge" in the C(T)/T^3 vs. T graph for voidless a-Si appear to be in good agreement with experiment; moreover our investigation shows that the presence of localized low-energy excitations in the vibrational spectrum of our models with voids strongly manifests itself as a sharp peak in C(T)/T^3 dependence at T < 3K. To our knowledge this is the first numerical simulation that provides adequate agreement with experiment for the very low-temperature properties of specific heat in disordered systems within the limits of harmonic approximation.Comment: 5 pages with 2 ps figures, submitted to PR