Total synthesis of squalamine dessulfate. Conjugate addition to Ru(II) complexes of styrenes.

Total synthesis of squalamine dessulfate. Conjugate addition to Ru(II) complexes of styrenes

When Cybersecurity Meets Accessibility: A Holistic Development Architecture for Inclusive Cyber-Secure Web Applications and Websites

In today’s technology-centric era, digital transformation has made accessibility and cybersecurity critical components for developing inclusive web applications that are essential in daily operations. However, current development models often treat accessibility and cybersecurity separately, leading to solutions that may excel in one area while lacking in the other. This paper addresses this gap by proposing the Holistic Security and Accessibility Layered Architecture (HSALA), a novel architectural model that integrates accessibility and cybersecurity throughout the development process. HSALA consists of five interconnected layers, each paired with a corresponding security layer, ensuring that both accessibility and security are embedded at every level. We conduct a theoretical and analytical case study comparing HSALA with the traditional three-layered architecture, demonstrating HSALA’s superiority in addressing contemporary challenges related to accessibility, cybersecurity, scalability, and user experience. The findings indicate that HSALA provides a robust framework for developing secure and inclusive web applications, promoting a more equitable digital ecosystem. We outline a roadmap for future work, including empirical validation and practical implementation strategies. HSALA represents a significant advancement in web application development, fostering inclusivity and trust in an increasingly digital society

Accessible IoT Dashboard Design with AI-Enhanced Descriptions for Visually Impaired Users

The proliferation of the Internet of Things (IoT) has led to an abundance of data streams and real-time dashboards in domains such as smart cities, healthcare, manufacturing, and agriculture. However, many current IoT dashboards emphasize complex visualizations with minimal textual cues, posing significant barriers to users with visual impairments who rely on screen readers or other assistive technologies. This paper presents AccessiDashboard, a web-based IoT dashboard platform that prioritizes accessible design from the ground up. The system uses semantic HTML5 and WAI-ARIA compliance to ensure that screen readers can accurately interpret and navigate the interface. In addition to standard chart presentations, AccessiDashboard automatically generates long descriptions of graphs and visual elements, offering a text-first alternative interface for non-visual data exploration. The platform supports multi-modal data consumption (visual charts, bullet lists, tables, and narrative descriptions) and leverages Large Language Models (LLMs) to produce context-aware textual representations of sensor data. A privacy-by-design approach is adopted for the AI integration to address ethical and regulatory concerns. Early evaluation suggests that AccessiDashboard reduces cognitive and navigational load for users with vision disabilities, demonstrating its potential as a blueprint for future inclusive IoT monitoring solutions

Electrochemical Detection of Glyphosate in Surface Water Samples Based on Modified Screen-Printed Electrodes

This study addresses the necessity to monitor the presence of glyphosate (Gly) in waters, highlighting the need for on-site detection of Gly by using electrochemical sensors in environmental and agricultural monitoring programs. Two approaches were employed: (1) modification with graphene decorated with gold nanoparticles (AuNPs-Gr) and dispersed in either dimethylformamide (DMF) or a solution containing Nafion and isopropanol (NAF), and (2) molecularly imprinted polymers (MIPs) based on polypyrrole (PPy) deposited on gold SPEs (AuSPE). Electrochemical characterization revealed that sensors made of AuNPs-Gr/SPCE exhibited enhanced conductivity, larger active area, and improved charge transfer kinetics compared to unmodified SPEs and SPEs modified with graphene alone. However, the indirect detection mechanism of Gly via complex formation with metallic cations in AuNPs-Gr-based sensors introduces complexities and compromises sensitivity and selectivity. In contrast, MIPPy/AuSPE sensors demonstrated superior performance, offering enhanced reliability and sensitivity for Gly analysis. The MIPPy/AuSPE sensor allowed the detection of Gly concentrations as low as 5 ng/L, with excellent selectivity and reproducibility. Moreover, testing in real surface water samples from the Olt River in Romania showed recovery rates ranging from 90% to 99%, highlighting the effectiveness of the detection method. Future perspectives include expanding the investigation to monitor Gly decomposition in aquatic environments over time, providing insights into the decomposition’s long-term effects on water quality and ecosystem health, and modifying regulatory measures and agricultural practices for mitigating its impact. This research contributes to the development of robust and reliable electrochemical sensors for on-site monitoring of Glyphosate in environmental and agricultural settings