Unraveling breast cancer prognosis: a novel model based on coagulation-related genes

ObjectiveBreast cancer is highly heterogeneous, presenting challenges in prognostic assessment. Developing a universally applicable prognostic model could simplify clinical decision-making. This study aims to develop and validate a novel breast cancer prognosis model using coagulation-related genes with broad clinical applicability.MethodsA total of 203 genes related to coagulation were obtained from the KEGG database, and the mRNA data of 1,099 tumor tissue samples and 572 samples of normal tissue were retrieved from the TCGA-BRCA cohort and GTEx databases. The R package “limma” was utilized to detect variations in gene expression related to coagulation between the malignancies and normal tissue. A model was constructed in the TCGA cohort through a multivariable Cox regression analysis, followed by validation using the GSE42568 dataset as the testing set. Constructing a nomogram incorporating clinical factors to enhance the predictive capacity of the model. Utilizing the ESTIMATE algorithm to investigate the immune infiltration levels in groups with deferent risk. Performing drug sensitivity analysis using the “oncoPredict” package.ResultsA risk model consisting of six coagulation-associated genes (SERPINA1, SERPINF2, C1S, CFB, RASGRP1, and TLN2) was created and successfully tested for validation. Identified were 6 genes that serve as protective factors in the model’s development. Kaplan-Meier curves revealed a worse prognosis in the high-risk group compared to the low-risk group. The ROC analysis showed that the model accurately forecasted the overall survival (OS) of breast cancer patients at 1, 3, and 5 years. Nomogram accompanied by calibration curves can also provide better guidance for clinical decision-making. The low-risk group is more likely to respond well to immunotherapy, whereas the high-risk group may show improved responses to Gemcitabine treatment. Furthermore, individuals in distinct risk categories displayed different responses to various medications within the identical therapeutic category.ConclusionWe established a breast cancer prognostic model incorporating six coagulation-associated genes and explored its clinical utility. This model offers valuable insights for clinical decision-making and drug selection in breast cancer patients, contributing to personalized and precise treatment advancements

Edge Computing-Enabled Wireless Sensor Networks for Multiple Data Collection Tasks in Smart Agriculture

At present, precision agriculture and smart agriculture are the hot topics, which are based on the efficient data collection by using wireless sensor networks (WSNs). However, agricultural WSNs are still facing many challenges such as multitasks, data quality, and latency. In this paper, we propose an efficient solution for multiple data collection tasks exploiting edge computing-enabled wireless sensor networks in smart agriculture. First, a novel data collection framework is presented by merging WSN and edge computing. Second, the data collection process is modeled, including a plurality of sensors and tasks. Next, according to each specific task and correlation between task and sensors, on the edge computing server, a double selecting strategy is established to determine the best node and sensor network that fulfills quality of data and data collection time constraints of tasks. Furthermore, a data collection algorithm is designed, based on set values for quality of data. Finally, a simulation environment is constructed where the proposed strategy is applied, and results are analyzed and compared to the traditional methods. According to the comparison results, the proposal outperforms the traditional methods in metrics.</jats:p