Risk-sensitive investment in a finite-factor model

A new jump diffusion regime-switching model is introduced, which allows for linking jumps in asset prices with regime changes. We prove the existence and uniqueness of the solution to the risk-sensitive asset management criterion maximisation problem in this setting. We provide an ODE for the optimal value function, which may be efficiently solved numerically. Relevant probability measure changes are discussed in the appendix. The approach of Klebaner and Lipster (2014) is used to prove the martingale property of the relevant density processes.Comment: 23 pages, 1 figur

Early Science with the Large Millimeter Telescope: an energy-driven wind revealed by massive molecular and fast X-ray outflows in the Seyfert Galaxy IRAS 17020+4544

We report on the coexistence of powerful gas outflows observed in millimeter and X-ray data of the Radio-Loud Narrow Line Seyfert 1 Galaxy IRAS 17020+4544. Thanks to the large collecting power of the Large Millimeter Telescope, a prominent line arising from the 12CO(1-0) transition was revealed in recent observations of this source. The complex profile is composed by a narrow double-peak line and a broad wing. While the double-peak structure may be arising in a disk of molecular material, the broad wing is interpreted as the signature of a massive outflow of molecular gas with an approximate bulk velocity of -660 km/s. This molecular wind is likely associated to a multi-component X-ray Ultra-Fast Outflow with velocities reaching up to ~0.1c and column densities in the range 10^{21-23.9} cm^-2 that was reported in the source prior to the LMT observations. The momentum load estimated in the two gas phases indicates that within the observational uncertainties the outflow is consistent with being propagating through the galaxy and sweeping up the gas while conserving its energy. This scenario, which has been often postulated as a viable mechanism of how AGN feedback takes place, has so far been observed only in ULIRGs sources. IRAS 17020+4544 with bolometric and infrared luminosity respectively of 5X10^{44} erg/s and 1.05X10^{11} L_sun appears to be an example of AGN feedback in a NLSy1 Galaxy (a low power AGN). New proprietary multi-wavelength data recently obtained on this source will allow us to corroborate the proposed hypothesis.Comment: Accepted for publication on ApJ Letters, 9 pages, 4 figure

A Huge Drop in X-ray Luminosity of the Non-Active Galaxy RXJ1242.6-1119A, and First Post-Flare Spectrum - Testing the Tidal Disruption Scenario

It has been suggested that an unavoidable consequence of the existence of supermassive black holes, and the best diagnostic of their presence in non-active galaxies, would be occasional tidal disruption of stars captured by the black holes. These events manifest themselves in form of luminous flares powered by accretion of debris from the disrupted star into the black hole. Candidate events among optically non-active galaxies emerged in the past few years. For the first time, we have looked with high spatial and spectral resolution at one of these most extreme variability events ever recorded among galaxies. Here, we report measuring a factor ~200 drop in luminosity of the X-ray source RXJ 1242-1119 with the X-ray observatories Chandra and XMM-Newton, and perform key tests of the favored outburst scenario, tidal disruption of a star by a supermassive black hole. We show that the detected `low-state' emission has properties such that it must still be related to the flare. The power-law shaped post-flare X-ray spectrum indicates a `hardening' compared to outburst. The inferred black hole mass, the amount of liberated energy, and the duration of the event favor an accretion event of the form expected from the (partial or complete) tidal disruption of a star (abstract abbreviated).Comment: to appear in March 1 issue of ApJ Letters (submitted Nov. 10, accepted in Dec. 2003); background information available at http://www.xray.mpe.mpg.de/~skomossa

A characterization of the NGC 4051 soft X-ray spectrum as observed by XMM-Newton

Soft X-rays high resolution spectroscopy of obscured AGNs shows the existence of a complex soft $X$-ray spectrum dominated by emission lines of He and H-like transitions of elements from Carbon to Neon, as well as L-shell transitions due to iron ions. In this paper we characterize the XMM-Newton RGS spectrum of the Seyfert 1 galaxy NGC 4051 observed during a low flux state and infer the physical properties of the emitting and absorbing gas in the soft X-ray regime. X-ray high-resolution spectroscopy offers a powerful diagnostic tool since the observed spectral features strongly depend on the physical properties of matter (ionization parameter U, electron density n_e, hydrogen column density N_H), which in turn are tightly related to the location and size of the X-ray emitting clouds. We carried out a phenomenological study to identify the atomic transitions detected in the spectra. This study suggests that the spectrum is dominated by emission from a photoionised plasma. Then, we used the photoionization code Cloudy to produce synthetic models for the emission line component and the warm absorber observed during phases of high intrinsic luminosity. The low state spectrum cannot be described by a single photoionization component. A multi-ionization phase gas with ionization parameter in the range log U = 0.63-1.90 and column density log N_H = 22.10-22.72 cm^-2 is required, while the electron density n_e remains unconstrained. A warm absorber medium is required by the fit with parameters log U = 0.85, log N_H = 23.40 and log n_e \ut< 5. The model is consistent with an X-ray emitting regions at a distance > 5 x 10^-2 pc from the central engine.Comment: Accepted for publication on section 4 "Extragalactic astronomy" of Astronomy and Astrophysics, 2010, 12 pages, 8 Figures, 4 Tables, in printer format. A few typos corrected

QuantiDOPA: A Quantification Software for Dopaminergic Neurotransmission SPECT

Quantification of neurotransmission Single-Photon Emission Computed Tomography (SPECT) studies of the dopaminergic system can be used to track, stage and facilitate early diagnosis of the disease. The aim of this study was to implement QuantiDOPA, a semi-automatic quantification software of application in clinical routine to reconstruct and quantify neurotransmission SPECT studies using radioligands which bind the dopamine transporter (DAT). To this end, a workflow oriented framework for the biomedical imaging (GIMIAS) was employed. QuantiDOPA allows the user to perform a semiautomatic quantification of striatal uptake by following three stages: reconstruction, normalization and quantification. QuantiDOPA is a useful tool for semi-automatic quantification inDAT SPECT imaging and it has revealed simple and flexibl

Exome sequencing in a consanguineous family clinically diagnosed with early-onset Alzheimer's disease identifies a homozygous CTSF mutation

We have previously reported the whole genome genotyping analysis of 2 consanguineous siblings clinically diagnosed with early onset Alzheimer's disease (AD). In this analysis, we identified several large regions of homozygosity shared between both affected siblings, which we suggested could be candidate loci for a recessive genetic lesion underlying the early onset AD in these cases. We have now performed exome sequencing in one of these siblings and identified the potential cause of disease: the CTSF c.1243G>A:p.Gly415Arg mutation in homozygosity. Biallelic mutations in this gene have been shown to cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis with some cases resembling the impairment seen in AD

Comparison of methods for the analysis of Phase Sensitivity Inversion Recovery Images in the Assessment of Myocardial Infarction

Métodos estadísticos para análisis de MRI PSI

Asymmetric data acquisition system for an endoscopic PET-US detector

According to current prognosis studies of pancreatic cancer, survival rate nowadays is still as low as 6% mainly due to late detections. Taking into account the location of the disease within the body and making use of the level of miniaturization in radiation detectors that can be achieved at the present time, EndoTOFPET-US collaboration aims at the development of a multimodal imaging technique for endoscopic pancreas exams that combines the benefits of high resolution metabolic information from time-of- flight (TOF) positron emission tomography (PET) with anatomical information from ultrasound (US). A system with such capabilities calls for an application-specific high-performance data acquisition system (DAQ) able to control and readout data from different detectors. The system is composed of two novel detectors: a PET head extension for a commercial US endoscope placed internally close to the region-of-interest (ROI) and a PET plate placed over the patient's abdomen in coincidence with the PET head. These two detectors will send asymmetric data streams that need to be handled by the DAQ system. The approach chosen to cope with these needs goes through the implementation of a DAQ capable of performing multi-level triggering and which is distributed across two different on-detector electronics and the off-detector electronics placed inside the reconstruction workstation. This manuscript provides an overview on the design of this innovative DAQ system and, based on results obtained by means of final prototypes of the two detectors and DAQ, we conclude that a distributed multi-level triggering DAQ system is suitable for endoscopic PET detectors and it shows potential for its application in different scenarios with asymmetric sources of data

A new PET prototype for proton therapy: comparison of data and Monte Carlo simulations

Ion beam therapy is a valuable method for the treatment of deep-seated and radio-resistant tumors thanks to the favorable depth-dose distribution characterized by the Bragg peak. Hadrontherapy facilities take advantage of the specific ion range, resulting in a highly conformal dose in the target volume, while the dose in critical organs is reduced as compared to photon therapy. The necessity to monitor the delivery precision, i.e. the ion range, is unquestionable, thus different approaches have been investigated, such as the detection of prompt photons or annihilation photons of positron emitter nuclei created during the therapeutic treatment. Based on the measurement of the induced β+ activity, our group has developed various in-beam PET prototypes: the one under test is composed by two planar detector heads, each one consisting of four modules with a total active area of 10 × 10 cm2. A single detector module is made of a LYSO crystal matrix coupled to a position sensitive photomultiplier and is read-out by dedicated frontend electronics. A preliminary data taking was performed at the Italian National Centre for Oncological Hadron Therapy (CNAO, Pavia), using proton beams in the energy range of 93–112 MeV impinging on a plastic phantom. The measured activity profiles are presented and compared with the simulated ones based on the Monte Carlo FLUKA package