“The Tremendous Products of a Son of the Gods.” Missa solemnis (Op. 123), Overture (Op. 124), and Ninth Symphony (Op. 125)

The premiere of Beethoven’s Ninth Symphony at the Kärntnertortheater in Vienna on May 7, 1824, is generally considered a milestone in music history. This article argues against the common characterization that Beethoven, in this, his (last) academy, programmed a monumental symphony and, perhaps with some embarrassment, a few filler pieces, but instead very consciously chose to highlight his three most recently composed orchestral works: the overture to the festival play Die Weihe des Hauses op. 124; Kyrie, Credo and Agnus Dei of the Missa solemnis op. 123; and the Ninth Symphony op. 125. Listening to these three works together opens up interesting perspectives on the expressive potential of Beethoven’s late orchestral works: despite the different occasions of composition and genre conventions, Beethoven implemented similar aesthetic ideas in them which manifest themselves, among other things, in numerous fugues, similar symbolic motifs, and interpolated war reminiscences

SeptiFast versus blood culture in clinical routine – A report on 3 years experience

Background In recent years a multiplex real-time PCR (SeptiFast) has been introduced, allowing detection of 25 common blood pathogens considerably faster than conventional blood culture. Methods SeptiFast was applied routinely in addition to blood culture in cases of critically ill patients with fever and other signs of severe systemic infections. In this study data of 470 episodes were retrospectively analysed to assess the impact of various parameters, such as clinical indications, assigning ward and antimicrobial treatment on test outcome using a multivariate logistic model. Results After exclusion of microorganisms classified as contaminants, the concordance between SeptiFast and blood culture was 85.5%. SeptiFast detected 98 out of 120, while blood culture merely found 63 out of 120 potential pathogens. In comparison to blood culture, SeptiFast showed considerably higher positivity rates in sepsis, pneumonia and febrile immunosuppression and a lower rate in endocarditis. The highest positivity and concordance between tests was shown in patients from the emergency room (P = 0.007). Conclusions The results obtained in this study are similar to those from prospective settings confirming the robustness of the SeptiFast assay in routine use. Our data suggest that SeptiFast is a valuable add-on to blood culture and may increase the diagnostic efficiency of a microbiological laboratory.(VLID)354527