Retrospektive monozentrische Studie zur Anwendung von Ruxolitinib bei akuter, chronischer und \ufcberlappender Graft-versus-Host-Disease (GVHD), einschlie flich GVHD im Zusammenhang mit Spender-Lymphozyten-Infusionen

Hematopoietic stem cell transplantation (HSCT) is an established method for the treatment of malignant and non-malignant hematological diseases. It is frequently considered the only potential curative therapy but is linked to a high transplant-associated morbidity and mortality. A particularly feared complication is Graft versus Host Disease (GVHD), in which the transplanted donor immune cells recognize the recipient's body as foreign and subsequently trigger a complex immune response that can lead to inflammation, apoptosis, and fibrosis. Depending on the symptoms and the temporal relationship of occurrence, GVHD can be classified as acute, chronic, and overlap GVHD. To prevent or reduce the intensity of this disease, immunosuppressive prophylaxis is started after allogeneic stem cell transplantation. However, about 50% of transplant recipients develop GVHD. Steroids are usually started as first-line treatment. If this fails, there is no established and standardized therapy approved as second line. Ruxolitinib (RUX) has demonstrated safety and efficacy in both acute and chronic GVHD. Official approval for both indications is expected from the Food and Drug Administration (FDA) and the European Drug Agency (EMA). However, overlap GVHD and GVHD induced by interventional (including preemptive) donor lymphocyte infusion (DLI), which were also included in this retrospective data analysis, were excluded from the pivotal prospective trials that showed a good response to RUX. The aim of this work was to show and compare the best, current response, and the overall survival (OS) of patients with acute, chronic but also those with overlap and DLI induced GVHD to RUX.Author Raphael LoislAbweichender Titel laut cbersetzung der Verfasserin/des VerfassersMasterarbeit Universit\ue4t Linz 202

"Ich sah in Verzückung ein Gesicht". Zur Prophetie in der Erzähllogik der Apg am Beispiel der Petrusvision (10,9-16; 11,5-10)

Prophecy plays an important part in the unfolding of events in Acts – a part, not only acted out by those, who are explicitly called προφῆται. Peter, for example, experiences an ecstatic vision (10:9‒16; 11:5‒10), which shows remarkable similarities to prophetic visions of the O.T. Also other protagonists to some extent seem to be characterised after a prophetic model. This impression is strengthened by a key-passage for the comprehension of the meaning and function of prophecy in Acts: Peter opens his speech at Pentecost with a quotation from Joel 3:1‒5 (Acts 2:17‒21), stating that, after receiving the gift of the Spirit, all the people of God will prophesy, see visions and dreams – an announcement fulfilled in the narrative of Acts

High-resolution seismic reflection data acquisition and interpretation, Lake Neusiedl, Austria, northwest Pannonian Basin

A combined 400+ km of single- and multichannel seismic reflection data were acquired on Lake Neusiedl in northeast Austria in May 2013. This geophysical campaign was a multinational academic effort among the Universities of Vienna, Budapest, Bremen, and Southampton. Lake Neusiedl is an exceptionally shallow lake, with an average water depth of only approximately 1.4 m. Although high-resolution single-channel seismic reflection data have been collected before on this lake, the multichannel seismic acquisition, towing a 60 m cable and an air gun behind a retrofitted ferry boat, was a completely new approach in this area. The quality of the multichannel data turned out to be exceptionally good; i.e., the high-frequency data illuminated the subsurface of the lake for the first time, down to the pre-Cenozoic basement at approximately 600 m depth. The most prominent findings of the new data include (1) a consistent southeasterly dip of erosionally truncated Late Miocene (Pannonian) sediments beneath a very thin Holocene mud layer, (2) the presence of major throughgoing fault systems (including a positive flower structure), (3) at least one Pannonian progradational sequence defined by seismic clinoforms indicating a paleowater depth of approximately 40–80 m, (4) flat spots in several locations of the study area corresponding to possibly biogenic gas in a few hundred meters depth beneath the lake, (5) vertical data wipeouts, which are interpreted as gas chimneys reaching the lake bottom, and (6) definition of the pre-Cenozoic basement. Interestingly, the gas chimneys are interpreted to correspond to the well-known gas seeps (“Kochbrunnen”) in Lake Neusiedl, which were originally described as subaqueous water springs on the lake floor responsible for ice-free areas in the lake ice cover during winter. </jats:p

Shoreline configurations affect dispersal patterns of fish larvae in a large river

Abstract The dispersal patterns of marked larvae of the nase carp (Chondrostoma nasus L.) were observed alongside dissimilar shoreline configurations in the main channel of the free-flowing Austrian Danube and compared with those of floating particles to investigate the mode of dispersal (active–passive). Individuals of different larval stages and floats at similar densities were released at an artificial rip-rap with groynes and a rehabilitated gravel bar. In both habitats, marked individuals were recaptured during the sampling period of 4 d after release. Relevant shoreline attributes for larval dispersal, such as the accessibility of nursery habitats, connectivity between adjacent habitats, and retention potential, were more pronounced at the gravel bar than at the rip-rap. At the gravel bar, larvae moved upstream and downstream within the connected bankside nurseries and displayed longer residence times. Larvae settled in groyne fields along the rip-rap as well; however, longitudinal dispersal was disrupted by groynes, forcing larvae to enter the main channel. Rather than settling in subsequent groyne fields, we assume that these larvae are displaced downstream and potentially lost from the local population.</jats:p

The Danube so colourful: A potpourri of plastic litter outnumbers fish larvae in Europe's second largest river

AbstractPrevious studies on plastic pollution of aquatic ecosystems focused on the world's oceans. Large rivers as major pathways for land-based plastic litter, has received less attention so far. Here we report on plastic quantities in the Austrian Danube. A two year survey (2010, 2012) using stationary driftnets detected mean plastic abundance (n = 17,349; mean ± S.D: 316.8 ± 4664.6 items per 1000 m−3) and mass (4.8 ± 24.2 g per 1000 m−3) in the river to be higher than those of drifting larval fish (n = 24,049; 275.3 ± 745.0 individuals. 1000 m−3 and 3.2 ± 8.6 g 1000 m−3). Industrial raw material (pellets, flakes and spherules) accounted for substantial parts (79.4%) of the plastic debris. The plastic input via the Danube into the Black Sea was estimated to 4.2 t per day