Prozessorientiertes Qualitätsmanagement (an der Fachhochschule Münster)

Je weiter entwickelt Qualitätsüberlegungen in einer Hochschule sind, desto stärker muss eine Verzahnung mit dem hochschulweiten Management erfolgen. Gezeigt wird am Beispiel der Fachhochschule Münster, wie dies gelingen kann, wenn Qualitätsziele systematisch aus den Hochschulzielen abgeleitet werden und zudem Prozessqualität als weitere Dimension neben der Ergebnis- und Strukturqualität in den Blick genommen wird. Im Vordergrund steht dabei der Bereich Studium und Lehre, für den gezeigt wird, wie einerseits durch Systematisieren und Konkretisieren - etwa durch den Einsatz einer Academic Scorecard - strategische Managementideen zu pragmatischen Vorgaben für das Alltagshandeln aller Hochschulakteure werden. Andererseits wird deutlich, wie mit Hilfe von Prozessbeschreibungen Arbeitsabläufe qualitätsgesteuert abgewickelt werden können. Dank dieser Vorgehensweise ist eine Übertragung aus dem Bereich Studium und Lehre auf alle Handlungsfelder der Hochschule möglich; um zu einem hochschulweiten Qualitätsmanagementsystem zu kommen, muss dies der nächste Schritt sein. (DIPF/Orig.

Unbalanced tree search on a manycore system using the GPI programming model

The recent developments in computer architectures progress towards systems with large core count (Manycore) which expose more parallelism to applications. Some applications named irregular and unbalanced applications demand a dynamic and asynchronous load balance implementation to utilize the full performance a Manycore system. For example, the recently established Graph500 benchmark aims at such applications. The UTS benchmark characterizes the performance of such irregular and unbalanced computations with a tree-structured search space that requires continuous dynamic load balancing. GPI is a PGAS API that delivers the full performance of RDMA-enabled networks directly to the application. Its programming model focuses the use of one-sided asynchronous communication, overlapping computation and communication. In this paper we address the dynamic load balancing requirements of unbalanced applications using the GPI programming model. Using the UTS benchmark, we detail the implementation of a work stealing algorithm using GPI and present the performance results. Our performance evaluation shows significant improvements when compared with the optimized MPI version with a maximum performance of 9.5 billion nodes per second on 3072 cores

A Linear Multiplexed Electrospray Thin Film Deposition System

Liquid spray is essential to industries requiring processes such as spray coating, spray drying, spray pyrolysis, or spray cooling. This thesis reports the design, fabrication, and characterization of a thin film deposition system which utilizes a linear multiplexed electrospray (LINES) atomizer. First, a thorough review of the advantages and limitations of prior multiplexed electrospray systems leads to discussion of the design rationale for this work. Next, the line of charge model was extended to prescribe the operating conditions for the experiments and to estimate the spray profile. The spray profile was then simulated using a Lagrangian model and solved using a desktop supercomputer based on Graphics Processing Units (GPUs). The simulation was extended to estimate the droplet number density flux during deposition. Pure ethanol was electrosprayed in the cone-jet mode from a 51-nozzle aluminum LINES atomizer with less than 3% relative standard deviation in the D10 average droplet diameter as characterized using Phase Doppler Interferometry (PDI). Finally a 25-nozzle LINES was integrated into a thin film deposition system with a heated, motion controlled stage, to deposit TiO2 thin films onto silicon wafers from an ethanol based nanoparticle suspension. The resulting deposition pattern was analyzed using SEM, optical profilometry, and macro photography and compared with the numerical simulation results. The LINES tool developed here is a step forward to enabling the power of electrospray for industrial manufacturing applications in clean energy, health care, and electronic

In vitro modeling of neuronal ceroid lipofuscinosis (NCL): Patient fibroblasts and their reprogrammed derivatives as human models of NCL

The discovery of resetting human somatic cells via introduction of four transcription factors into an embryonic stem cell-like state that enables the generation of any cell type of the human body has revolutionized the field of medical science. The generation of patient-derived iPSCs and the subsequent differentiation into the cells of interest has been, nowadays, widely used as model system for various inherited diseases. The aim of this thesis was to generate iPSCs and to subsequently derive NPCs which can be differentiated into neurons in order to model the two most common forms of the NCLs: LINCL which is caused by mutations within the TPP1 gene, encoding a lysosomal enzyme, and JNCL which is caused by mutations within the CLN3 gene, affecting a lysosomal transmembrane protein. It was shown that patient-derived fibroblasts can be successfully reprogrammed into iPSCs by using retroviral vectors that introduced the four transcription factors POU5F1, SOX2, KLF4 and MYC. The generated iPSCs were subsequently differentiated into expandable NPCs and finally into mature neurons. Phenotype analysis during the different stages, namely pluripotent iPSCs, multipotent NPCs and finally differentiated neurons, revealed a genotype-specific progression of the disease. The earliest events were observed in organelle disruption such as mitochondria, Golgi and ER which preceded the accumulation of subunit c of the mitochondrial ATPase complex that was only apparent in neurons. However, none of these events led to neurodegeneration in vitro. The established disease models recapitulate phenotypes reported in other NCL disease models such as mouse, dog and sheep model systems. More importantly, the hallmark of the NCLs, accumulation of subunit c in neurons, could be reproduced during the course of disease modeling which demonstrates the suitability of the established system. Moreover, the derived expandable NPC populations can be used for further applications in drug screenings. Their robust phenotypes such as low levels of TPP1 activity in LINCL patient-derived NPCs or cytoplasmic vacuoles, containing storage material, observed in CLN3 mutant NPCs, should serve as possible phenotypic read-outs

The Role of Landmarks in Territory Maintenance by the Black Saddlebags Dragonfly, Tramea lacerata

Territoriality can reduce competition for resources, but territorial defense can be costly. Therefore any behavior that reduces territorial costs may increase the net benefit of territoriality. Some species will align their territory boundaries with conspicuous landmarks that may serve to reduce defense costs. Dragonflies, including black saddlebags (Tramea lacerata), defend territories at breeding sites, keeping rival males away to allow themselves access to females. We used three treatments to investigate whether T. lacerata used landmarks: constraining landmarks (an object that provided a physical barrier to flight), non-constraining landmarks (an object of the same dimensions and construction that did not impede flight), and a control without landmarks. We observed patrolling male black saddlebags and recorded the locations of turns at their territory boundary and interactions with other dragonflies. When either type of landmark was present, individuals placed their boundary at the landmark far more often than any other location. In addition, individuals that used landmarks had a significantly narrower range of tum locations than those that did not. Unlike other studies the use of a landmark did not seem to reduce defense costs, and interestingly not all individuals used landmarks when they were provided. The lack of an observed reduction in defensive costs could be due to the collection of data during territory maintenance rather than territory establishment, when the costs may have been higher, or landmarks may be important as part of a spatial reference system that aids male dragonflies in efficiently searching for females