Ensaio comparativo avançado de arroz de sequeiro em Redenção, Pará - ano agrícola 1998/1999.

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New trends in ICT regarding education

In the 21st century and because of the exponential growth of the Internet and Information Communication Technologies (ICT), people lived in a technological age, in all areas and in all contexts, we have daily contact with technology, with access to information, linked to it, we have a constant update of technological services and tools that change the method we study, work, communicate and socialize on an unprecedented scale. These constant changes oblige everyone regardless the age, gender or profession to possess a range of functional and critical thinking skills, such as Information Literacy, Media Literacy and Technology Literacy. This evolution, forces, the promoters of education, to be always aware of changes that society is introducing outside of the classroom. Today students don’t have the same role that used to, independently of age, they are very active and no longer the same introverted child that studied a few years ago in the classrooms. Also the educational environments can be created anywhere and used everywhere. According to this, students are used to seeking different forms and ways of motivation in and out of the classroom, they need that the learning and teaching process move along with the society and ICT changes. In order to ensure the success of today’s students, it’s important to give them the technological skills to make the correct use of ICT, to perform essential tasks for their training such as research and information selection, problems solvers and decision makers, creative and effective users of productivity tools and communicators, collaborators, publishers and producers of contents. The main purpose of this communication is, to show a part of ICT tools that can be used in educational settings to support learners, helping them to develop key skills in their training process, it’s also relevant to show how these tools can help teachers to achieve these objectives on the daily activities.No século XXI e por causa do crescimento exponencial da Internet e das Tecnologias de Comunicação da Informação (TIC), as pessoas vivem numa era tecnológica, em todas as áreas e em todos os contextos. Temos contacto diário com tecnologia, com acesso à informação e associado a este fenómeno existe uma constante atualização de serviços tecnológicos e ferramentas que mudam os métodos de estudo, trabalho, comunicação e socialização numa escala sem precedentes. Essas mudanças constantes obrigam a todos, independentemente da idade, sexo ou profissão, a possuir uma gama de habilidades de pensamento funcional e crítico, como literacia para a informação, literacia para os media e literacia tecnológica. Essa evolução, força os responsáveis da educação, a estarem sempre conscientes das mudanças que a sociedade está introduzindo fora da sala de aula. Hoje, os alunos não têm o mesmo papel que há uns anos atrás. As crianças são muito ativas, não revelando os comportamentos introvertidos que anteriormente evidenciavam. Além disso, os ambientes educacionais podem ser criados em qualquer lugar e usados em todo o lado. Os alunos estão habituados a procurar diferentes formas de motivação dentro e fora da sala de aula, eles precisam que o processo de ensino-aprendizagem acompanhe as mudanças da sociedade e das TIC. A fim de garantir o sucesso dos estudantes de hoje, é importante dar-lhes as habilidades tecnológicas para fazer o uso correto das TIC, para executar tarefas essenciais para sua formação, como a pesquisa e seleção de informações, aprender a solucionar problemas e a tomar decisões a ser utilizadores efetivos das ferramentas de produtividade, comunicação e colaboração, bem como serem editores e produtores de conteúdos. O principal objetivo desta comunicação é mostrar uma parte das ferramentas de TIC que podem ser usadas em ambientes educacionais para apoiar os alunos, ajudando-os a desenvolver habilidades-chave no seu processo formativo. Pretendemos também mostrar como é que essas ferramentas podem ajudar os professores a alcançar os objetivos pedagógicos nas atividades diárias

Assessment of the quality of life of patients with lung cancer using the Medical Outcomes Study 36-item Short-Form Health Survey

OBJECTIVE: To assess the quality of life of patients with lung cancer and to compare it with that of individuals without cancer. METHODS: The Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) was administered to 57 patients diagnosed with lung cancer, treated at the Lung Cancer Outpatient Clinic of the Hospital São Paulo, and to a control group of 57 individuals recruited from the Extra Penha workout group. The Mann-Whitney test was used to compare the groups, domain by domain. The first model of logistic regression was adjusted for male gender, nonsurgical treatment, Karnofsky performance status and smoking, which were included as predictors. The second model was adjusted for each SF-36 domain in order to identify increases in the proportions of patients in stage IIIB or IV. RESULTS: The lung cancer group and the control group presented the following mean scores, respectively, for the SF-36 domains: role limitations due to physical health problems, 29.39 ± 36.94 and 82.89 ± 28.80; role limitations due to emotional problems, 42.78 ± 44.78 and 86.55 ± 28.77; physical function, 56.49 ± 28.39 and 89.00 ± 13.80; vitality, 61.61 ± 23.82 and 79.12 ± 17.68; bodily pain, 62.72 ± 28.72 and 81.54 ± 19.07; general health, 62.51 ± 25.57 and 84.47 ± 13.47; emotional well-being, 68.28 ± 23.46 and 82.63 ± 17.44; and social functioning, 72.87 ± 29.20 and 91.67 ± 17.44. The logistic regression model showed that role limitations due to physical health problems, physical function and emotional well-being were predictors of stages IIIB and IV. CONCLUSIONS: The patients with lung cancer had a poorer quality of life, especially regarding physical aspects, than did the control subjects.OBJETIVO: Avaliar a qualidade de vida de pacientes com câncer de pulmão e compará-la com a qualidade de vida de indivíduos sem câncer. MÉTODOS: O questionário Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) foi aplicado em 57 pacientes com diagnóstico de câncer de pulmão provenientes do Ambulatório de Oncopneumologia do Hospital São Paulo e em um grupo controle de 57 indivíduos participantes do Grupo de Ginástica Extra Penha. O teste de Mann-Whitney foi utilizado para comparar cada domínio entre os grupos. O primeiro modelo de regressão logística foi ajustado para sexo masculino, tratamento não cirúrgico, índice de Karnofsky e tabagismo, que foram incluídos como preditores. O segundo modelo foi ajustado para cada domínio do SF-36 para identificar aumento na proporção de estádios IIIB e IV. RESULTADOS: O grupo com câncer de pulmão e o grupo controle apresentaram, respectivamente, as seguintes pontuações médias para os domínios do SF-36: aspectos físicos, 29,39 ± 36,94 e 82,89 ± 28,80; aspectos emocionais, 42,78 ± 44,78 e 86,55 ± 28,77; capacidade funcional, 56,49 ± 28,39 e 89,00 ± 13,80; vitalidade, 61,61 ± 23,82 e 79,12 ± 17,68; dor, 62,72 ± 28,72 e 81,54 ± 19,07; estado geral de saúde, 62,51 ± 25,57 e 84,47 ± 13,47; saúde mental, 68,28 ± 23,46 e 82,63 ± 17,44; e aspectos sociais, 72,87 ± 29,20 e 91,67 ± 17,44. O modelo de regressão logística demonstrou que aspectos físicos, capacidade funcional e saúde mental foram preditores de estádios IIIB e IV. CONCLUSÕES: Os pacientes com câncer de pulmão apresentaram pior qualidade de vida em relação ao grupo controle, principalmente em relação aos aspectos físicos.Universidade Federal de São Paulo (UNIFESP)Centro Universitário São CamiloUNIFESPSciEL

Solvation Structure of Uracil in Ionic Liquids

The local solvation environment of uracil dissolved in the ionic liquid 1-ethyl-3-methylimidazolium acetate has been studied using neutron diffraction techniques. At solvent:solute ratios of 3:1 and 2:1 ionic liquid:uracil, little perturbation of the ion-ion correlations compared to those of the neat ionic liquid are observed. We find that solvation of the uracil is driven predominantly by the acetate anion of the solvent. While short distance correlations exist between uracil and the imidazolium cation, the geometry of these contacts suggest that they cannot be considered as hydrogen bonds, in contrast to other studies by Araújo et al. (J. M. Araújo, A. B. Pereiro, J. N. Canongia-Lopes, L. P. Rebelo, I. M. Marrucho, J. Phys. Chem. B 2013, 117, 4109-4120). Nevertheless, this combination of interactions of the solute with both the cation and anion components of the solvents helps explain the high solubility of the nucleobase in this media. In addition, favorable uracil-uracil contacts are observed, of similar magnitude to those between cation and uracil, and are also likely to aid dissolutio

Occupational and leisure time physical activity in contrasting relation to ambulatory blood pressure

Background: While moderate and vigorous leisure time physical activities are well documented to decrease the risk for cardiovascular disease, several studies have demonstrated an increased risk for cardiovascular disease in workers with high occupational activity. Research on the underlying causes to the contrasting effects of occupational and leisure time physical activity on cardiovascular health is lacking. The aim of this study was to examine the relation of objective and self-report measures of occupational and leisure time physical activity with 24-h ambulatory systolic blood pressure (BP). Methods: Results for self-reported physical activity are based on observations in 182 workers (60% male, mean age 51 years), while valid objective physical activity data were available in 151 participants. The usual level of physical activity was assessed by 5 items from the Job Content Questionnaire (high physical effort, lifting heavy loads, rapid physical activity, awkward body positions and awkward positions of head or arms at work) and one item asking about the general level of physical activity during non-working time. On a regular working day, participants wore an ambulatory BP monitor and an accelerometer physical activity monitor during 24 h. Associations were examined by means of Analysis of Covariance. Results: Workers with an overall high level of self-reported occupational physical activity as well as those who reported to often lift heavy loads at work had a higher mean systolic BP at work, at home and during sleep. However, no associations were observed between objectively measured occupational physical activity and BP. In contrast, those with objectively measured high proportion of moderate and vigorous leisure time physical activity had a significantly lower mean systolic BP during daytime, while no differences were observed according to self-reported level of leisure time physical activity. Conclusions: These findings suggest that workers reporting static occupational physical activities, unlike general physically demanding tasks characterized by dynamic movements of large muscle groups, are related to a higher daily systolic BP, while high objective levels of moderate and vigorous leisure time physical activity are related to lower daytime systolic BP. Ambulatory systolic BP may be a physiological explanatory factor for the contrasting effects of occupational and leisure time physical activity

Tracking Quintessence and Cold Dark Matter Candidates

We study the generation of a kination-dominated phase in the context of a quintessential model with an inverse-power-law potential and a Hubble-induced mass term for the quintessence field. The presence of kination is associated with an oscillating evolution of the quintessence field and the barotropic index. We find that, in sizeable regions of the parameter space, a tracker scaling solution can be reached sufficiently early to alleviate the coincidence problem. Other observational constraints originating from nucleosynthesis, the inflationary scale, the present acceleration of the universe and the dark-energy-density parameter can be also met. The impact of this modified kination-dominated phase on the thermal abundance of cold dark matter candidates is investigated too. We find that: (i) the enhancement of the relic abundance of the WIMPs with respect to the standard paradigm, crucially depends on the hierarchy between the freeze-out temperature and the temperature at which the extrema in the evolution of the quintessence field are encountered, and (ii) the relic abundance of e-WIMPs takes its present value close to the temperature at which the earliest extremum of the evolution of the quintessence field occurs and, as a consequence, both gravitinos and axinos arise as natural cold dark matter candidates. In the case of unstable gravitinos, the gravitino constraint can be satisfied for values of the initial temperature well above those required in the standard cosmology.Comment: Final versio

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

Drugs targeting atrial-specific ion channels, K(v)1.5 or K(ir)3.1/3.4, are being developed as new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried out in non-cardiac cell lines or animal models may not accurately represent the physiology of a human cardiomyocyte (CM). In the current study, we tested whether human embryonic stem cell (hESC)-derived atrial CMs could predict atrial selectivity of pharmacological compounds. By modulating retinoic acid signaling during hESC differentiation, we generated atrial-like (hESC-atrial) and ventricular-like (hESC-ventricular) CMs. We found the expression of atrial-specific ion channel genes, KCNA5 (encoding Kv1.5) and KCNJ3 (encoding K-ir 3.1), in hESC-atrial CMs and further demonstrated that these ion channel genes are regulated by COUP-TF transcription factors. Moreover, in response to multiple ion channel blocker, vernakalant, and K(v)1.5 blocker, XEN-D0101, hESC-atrial but not hESC-ventricular CMs showed action potential (AP) prolongation due to a reduction in early repolarization. In hESC-atrial CMs, XEN-R0703, a novel K(ir)3.1/3.4 blocker restored the AP shortening caused by CCh. Neither CCh nor XEN-R0703 had an effect on hESC-ventricular CMs. In summary, we demonstrate that hESC-atrial CMs are a robust model for pre-clinical testing to assess atrial selectivity of novel antiarrhythmic drugs

Coeval perpendicular shortenings in the Brasilia belt : collision of irregular plate margins leading to oroclinal bending in the Neoproterozoic of central Brazil

The three belts which form the Tocantins province (central Brazil) records Neoproterozoic-EoPaleozoic collisions involving the Amazon and São Francisco paleocontinents and the Paraná continental block. The Brasília belt is a typical orocline bended around the WNW—ESE striking Pirineus Zone of High Strain (PZHS) and is comprised of the NE-trending (northern) and SE-trending (southern) segments. The Brasília dome is an N—S elliptical structural window situated in the center of the belt, at the eastern end of the PZHS. It evidences Di— D₂ and D₃ɴ shortenings (~ 750—590 Ma) due to ocean closure and Amazon- São Francisco collision following a WNW—ESE path, and demonstrates similar evolution for both segments of the belt. However, in the southern segment, D₁—D₂ structures are deformed by shortening in the SW-NE direction (D₃S). New data demonstrating D₁—D₂ and D₃ɴ tectonites deformed by D₃S struc- tures in the area close to the dome's SW margin and SE of the PZHS support understanding the Brasília belt and oroclinal bending as a consequence of the collision of two (Amazon and São Francisco) irregular continental margins leading to separation-rotation of the Paraná block from the Amazon paleocontinent and the Paraná-São Francisco collision