Fully automated calculation in fermion scattering

The package aITALC has been developed for fully automated calculations of two fermion production at e+ e- collider and other similar reactions. We emphasize the connection and interoperability between the different modules required for the calculation and the external tools Diana, Form and LoopTools. Results for e+ e- -> f anti-f, e+ e- are presented.Comment: 5 pages, 2 tables, 2 figures. Contribution to the X International Workshop on Advanced Computing and Analysis Techniques in Physics Research, ACAT 2005, May 22-27, 2005, Zeuthen (Germany

Automatized calculation of 2-fermion production with DIANA and aITALC

The family of two fermion final states is among the cleanest final states at the International Linear Collider (ILC) project. The package aITALC has been developed for a calculation of their production cross sections, and we present here benchmark numerical results in one loop approximation in the electroweak Standard Model. We are using packages like QGRAF, DIANA, FORM, LOOPTOOLS for intermediate steps.Comment: Contribution to the proceedings of the International Conference on Linear Colliders (LCWS 04), Paris, April 19-23, 2004. 5 pages, 1 figure, 5 table

The unique N-terminal sequence of the BKCa channel α-subunit determines its modulation by β-subunits

Large conductance voltage- and Ca2+-activated K+ (BKCa) channels are essential regulators of membrane excitability in a wide variety of cells and tissues. An important mechanism of modulation of BKCa channel activity is its association with auxiliary subunits. In smooth muscle cells, the most predominant regulatory subunit of BKCa channels is the β1-subunit. We have previously described that BKCa channels with distinctive N-terminal ends (starting with the amino acid sequence MDAL, MSSN or MANG) are differentially modulated by the β1-subunit, but not by the β2. Here we extended our studies to understand how the distinct N-terminal regions differentially modulate channel activity by β-subunits. We recorded inside-out single-channel currents from HEK293T cells co-expressing the BKCa containing three N-terminal sequences with two β1-β2 chimeric constructs containing the extracellular loop of β1 or β2, and the transmembrane and cytoplasmic domains of β2 or β1, respectively. Both β chimeric constructs induced leftward shifts of voltage-activation curves of channels starting with MANG and MDAL, in the presence of 10 or 100 μM intracellular Ca2+. However, MSSN showed no shift of the voltage-activation, at the same Ca2+ concentrations. The presence of the extracellular loop of β1 in the chimera resembled results seen with the full β1 subunit, suggesting that the extracellular region of β1 might be responsible for the lack of modulation observed in MSSN. We further studied a poly-serine stretch present in the N-terminal region of MSSN and observed that the voltage-activation curves of BKCa channels either containing or lacking this poly-serine stretch were leftward shifted by β1-subunit in a similar way. Overall, our results provide further insights into the mechanism of modulation of the different N-terminal regions of the BKCa channel by β-subunits and highlight the extension of this region of the channel as a form of modulation of channel activity

Automated calculations for massive fermion production with aITALC

The package aITALC has been developed for the automated calculation of radiative corrections to two-fermion production at $e^+ e^-$ colliders. The package uses Diana, Qgraf, Form, Fortran, FF, LoopTools, and further unix/linux tools. Numerical results are presented for $e^+e^- \to e^+e^-, mu^+mu^-, b \bar{s}, t \bar{c}$.Comment: Contribution to the proceedings of "Loops and Legs in Quantum Field Theory 2004", Zinnowitz, Usedom Island, Germany, April 2004. 5 pages, latex, espcrc2, 5 figures, 1 tabl

An Error Estimate Uniform in Time for Spectral Galerkin Approximations for the Equations for the Motion of a Chemical Active Fluid

Sin resume

Functional insights into modulation of BKCa channel activity to alter myometrial contractility

The large-conductance voltage- and Ca2+-activated K+ channel (BKCa) is an important regulator of membrane excitability in a wide variety of cells and tissues. In myometrial smooth muscle, activation of BKCa plays essential roles in buffering contractility to maintain uterine quiescence during pregnancy and in the transition to a more contractile state at the onset of labor. Multiple mechanisms of modulation have been described to alter BKCa channel activity, expression, and cellular localization. In the myometrium, BKCa is regulated by alternative splicing, protein targeting to the plasma membrane, compartmentation in membrane microdomains, and posttranslational modifications. In addition, interaction with auxiliary proteins (i.e., β1- and β2-subunits), association with G-protein coupled receptor signaling pathways, such as those activated by adrenergic and oxytocin receptors, and hormonal regulation provide further mechanisms of variable modulation of BKCa channel function in myometrial smooth muscle. Here, we provide an overview of these mechanisms of BKCa channel modulation and provide a context for them in relation to myometrial function

Automated use of DIANA for two-fermion production at colliders

We describe packages for the calculation of radiative corrections to two-fermion production at colliders. The packages use DIANA, and also QGRAF, FORM, Fortran, and further unix/linux tools. The one-loop calculations in the Standard Model are highly automatized with the package aITALC. Further, the automatic determination of all the matrix elements for two-loop corrections to massive Bhabha scattering in QED and the classification of their topologies and prototypes is done with DIANA. A generalization to the Standard Model is straightforward.Comment: To appear in the proceedings of ACAT03, Dec 2003, KEK, Japa