Strong CH^+ J = 1–0 emission and absorption in DR21

We report the first detection of the ground-state rotational transition of the methylidyne cation CH^+ towards the massive star-forming region DR 21 with the HIFI instrument onboard the Herschel satellite. The line profile exhibits a broad emission line, in addition to two deep and broad absorption features associated with the DR 21 molecular ridge and foreground gas. These observations allow us to determine a ^(12)CH^(+)J = 1–0 line frequency of ν = 835 137 ± 3 MHz, in good agreement with a recent experimental determination. We estimate the CH^+ column density to be a few 10^(13) cm^(-2) in the gas seen in emission, and >10^(14) cm^(-2) in the components responsible for the absorption, which is indicative of a high line of sight average abundance [CH^+] /[H] > 1.2 × 10^(-8). We show that the CH^+ column densities agree well with the predictions of state-of-the-art C-shock models in dense UV-illuminated gas for the emission line, and with those of turbulent dissipation models in diffuse gas for the absorption lines

Theory of Drop Formation

We consider the motion of an axisymmetric column of Navier-Stokes fluid with a free surface. Due to surface tension, the thickness of the fluid neck goes to zero in finite time. After the singularity, the fluid consists of two halves, which constitute a unique continuation of the Navier-Stokes equation through the singular point. We calculate the asymptotic solutions of the Navier-Stokes equation, both before and after the singularity. The solutions have scaling form, characterized by universal exponents as well as universal scaling functions, which we compute without adjustable parameters

Introduction to empathy: activation, definition, construct

This introduction to the collection offers an initial discussion of the concept of empathy, and its uses in both academic and popular discourse. I aim here to interrogate a general trend, currently observable particularly with reference to educational and corporate settings, in which ‘empathy’ has become somewhat of a buzz-word, an essential component that enhances the ‘human’ quality of the ways in which a company operates, or a curriculum is administered in a classroom. In the literature produced about, or sometimes by these sectors, there is frequent advocacy for the activation of empathy in professional and teacher-student relationships, while concrete definitions of empathy are rarely provided, and often taken for granted. On the other hand, in academic discourse, disciplinary approaches and objectives render it essential for definitions of empathy not only to be thoroughly expounded but also adequately justified in a specific disciplinary (or a specific cross-disciplinary) context. This discussion aims to offer a brief survey of some ways in which the conceptual tension between definitions and practical applications (or activations) of empathy have been, and can continue to be explored. This survey in turn will introduce the featured papers in this collection, initially delivered at a 2013 workshop on ‘Empathy’ at the UCL Joint Faculty Institute of Graduate Studies, contributions which will offer perspectives on socio-cultural, philosophical, artistic, and psychological constructs of empathy, both in its definition and potential activation

A bibliography of publications by Albert Bates Lord

Note: [at time of printing] All items listed here can be found in Ellis Library at the University of Missouri, Columbia, either in Special Collections (Ellis 401) or in open stacks (see the affixed call numbers below). Many journals are available online to University of Missouri faculty, staff, and students, and of course through other institutions as well. A full collection of article-length items is maintained in hard copy and on CD in Special Collections

Adherence to prescribing restrictions for HER2-positive metastatic breast cancer in Australia: A national population-based observational study (2001-2016)

Background: Targeted cancer therapy is often complex, involving multiple agents and chemotherapeutic partners. In Australia, prescribing restrictions are put in place to reflect existing evidence of cost-effectiveness of these medicines. As therapeutic options continue to expand, these restrictions may not be perceived to align with best practice and it is not known if their use in the real-world clinic adheres to these restrictions. We examined the treatment of women receiving trastuzumab for HER2-positive metastatic breast cancer (HER2+MBC) to determine the extent to which treatment adhered to national prescribing restrictions. Patients and methods: Our population-based, retrospective cohort study used dispensing records for every Australian woman initiating publicly-subsidised trastuzumab for HER2+MBC between 2001±2013, followed through 2016. We used group-based trajectory models (GBTMs) to cluster patients, first on their patterns of trastuzumab exposure, and then on their patterns of lapatinib and chemotherapy exposure. We described the characteristics of patients within each cluster, and examined their treatments and combinations of treatments to determine restriction adherence. Results: Of 5,052 patients initiating trastuzumab, 1,795 (36%) received at least one non-adherent HER2-targeted treatment. The most common non-adherent treatments were trastuzumab combinations involving vinorelbine (24% of non-adherent treatments); capecitabine (24%); and anthracyclines (10%). Non-adherent lapatinib use was observed in 4% of patients. GBTM identified three trastuzumab exposure clusters, each containing three further subclusters. The largest proportions of non-adherent treatments were in sub-clusters with longer trastuzumab exposure and more non-taxane chemotherapy. Patients in these sub-clusters were younger than those in sub-clusters with less non-adherent treatment. Conclusions: Our study highlights that, even during the relatively simpler treatment era of our study period, a substantial amount of treatment did not adhere to prescribing restrictions. As more trials are conducted exploring pertuzumab and T-DM1 in combination with different chemotherapies and other HER2-targeted therapies, the regulation and funding of HER2-targeted treatment will become more challenging

NGO Participation In Human Rights Law And Process: Latest Developments In The Effort To Develop An International Treaty On The Rights Of People With Disabilities

The human rights of people with disabilities traditionally have been ignored in mainstream international human rights theory and practice and in the work of international institutions