The Importance of Interdisciplinarity: Redefining the Health Belief Model

Throughout academia, there lacks an existence of a commonly utilized multicomponent and interdisciplinary approach in understanding our outside world. This thesis provides an analysis of the current state of interdisciplinarity and the need to develop interdisciplinary theory. Through this effort, the researcher utilizes the health belief model as a framework that is severely limited in applicable scope due to its constructs. Contrastingly, systems theory and game theory are validated as examples of theories with an interdisciplinary nature. Through the coding of the literature pertaining to the qualitative characteristics of the health belief model, game theory and systems theory, guidelines in developing interdisciplinary theory are proposed to challenge scholars in theory construct descriptors and usage. Further, the guidelines provided are applied to redefine the health belief model to offer perspective in how it can describe relationships outside of health. Through an interdisciplinary approach in theory development, scholars can begin to demonstrate the power and impact of knowledge sharing in solving some of society’s greatest challenges

Bone response to a Ca- and P-enriched titanium surface obtained by anodization

This study evaluated bone response to a Ca- and P- enriched titanium (Ti) surface treated by a multiphase anodic spark deposition coating (BSP-AK). Two mongrel dogs received bilateral implantation of 3 Ti cylinders (4.1 x 12 mm) in the humerus, being either BSP-AK treated or untreated (machined - control). At 8 weeks postimplantation, bone fragments containing the implants were harvested and processed for histologic and histomorphometric analyses. Bone formation was observed in cortical area and towards the medullary canal associated to approximately 1/3 of implant extension. In most cases, in the medullary area, collagen fiber bundles were detected adjacent and oriented parallel to Ti surfaces. Such connective tissue formation exhibited focal areas of mineralized matrix lined by active osteoblasts. The mean percentages of bone-to-implant contact were 2.3 (0.0-7.2 range) for BSP-AK and 0.4 (0.0-1.3 range) for control. Although the Mann-Whitney test did not detect statistically significant differences between groups, these results indicate a trend of BSP-AK treated surfaces to support contact osteogenesis in an experimental model that produces low bone-to-implant contact values.O objetivo desse estudo foi avaliar a resposta do tecido ósseo à superfície de titânio (Ti) enriquecida com Ca e P obtida por anodização (BSP-AK). Três cilindros de Ti (4,1 x 12 mm) BSP-AK ou usinado (controle) foram implantados bilateralmente nos úmeros de dois cães de raça indefinida. Oito semanas após a implantação, os fragmentos ósseos contendo os implantes foram removidos e processados para análises histológica e histomorfométrica. A formação óssea foi observada na região cortical e no canal medular até aproximadamente um terço da extensão do implante. Na maioria dos casos, feixes de fibras colágenas dispostos paralelamente à superfície do implante foram observados na região medular. Nessa região observaram-se também áreas focais de formação de matriz mineralizada e osteoblastos ativos. Os implantes do grupo BSP-AK apresentaram média de contato osso-implante 2,3%, com medidas variando de 0,0 a 7,2% e os do grupo controle tiveram média 0,4%, com medidas variando de 0,0 a 1,3%. Apesar do teste de Mann-Whitney não mostrar diferença estatisticamente significante entre os grupos, nossos resultados indicaram uma tendência para a ocorrência de osteogênese de contato na superfície BSP-AK em um modelo experimental que resulta em baixos valores de contato osso-implante.FAPES

Episode 40: #UofSCLove: A Valentine’s Day Edition of Campus Love

Cupid\u27s arrows find their mark in this special Valentine\u27s Day episode about eight couples who fell in love on the University of South Carolina campus.https://scholarcommons.sc.edu/rememberingthedays/1039/thumbnail.jp

A patient with concurrent EBV-negative diffuse large B-cell lymphoma and angioimmunoblastic T-cell lymphoma: a case report

IntroductionDiffuse large B-cell lymphoma (DLBCL) is an aggressive form of non-Hodgkin lymphoma that accounts for approximately a quarter of all lymphomas in the United States. It is rare to have co-occurring T cell lymphoma with DLBCL as they often develop following treatment of DLBCL rather than concomitantly.Case presentationWe report a 71-year-old male patient diagnosed with Epstein–Barr virus (EBV) -negative DLBCL with concurrent angioimmunoblastic T-cell lymphoma (AITL). A right inguinal lymph node biopsy demonstrated aggressive B-cell lymphoma consistent with DLBCL with the non-germinal center immunophenotype that was EBV-negative. Furthermore, abnormal T-cells with irregular nuclear contours were found in T cell receptor sequencing with monoclonal gamma and beta T cells. A bone marrow biopsy demonstrated occasional large atypical CD3+PD1+ T cells with corresponding identical T-cell receptor clones in the lymph node biopsy. Next-generation sequencing from the lymph node biopsy demonstrated dual inactivating TET2 mutations.ConclusionComposite DLBCL and AITL is a rare occurrence and the absence of EBV is even more so. Given the rare nature of having these two hematologic malignancies simultaneously, no standard of care exists. However, R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) is a regimen commonly used in both malignancies individually, and therefore this patient was treated using this approach achieving a partial remission after four cycles of therapy. Unfortunately, he developed refractory disease 1 month after completion of six cycles of R-CHOP

Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice

Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet containing farmed salmon prevents or contributes to insulin resistance in mice. Methodology/Principal Findings: Adult male C57BL/6J mice were fed control diet (C), a very high-fat diet without or with farmed Atlantic salmon fillet (VHF and VHF/S, respectively), and Western diet without or with farmed Atlantic salmon fillet (WD and WD/S, respectively). Other mice were fed VHF containing farmed salmon fillet with reduced concentrations of persistent organic pollutants (VHF/S-POPs). We assessed body weight gain, fat mass, insulin sensitivity, glucose tolerance, ex vivo muscle glucose uptake, performed histology and immunohistochemistry analysis, and investigated gene and protein expression. In comparison with animals fed VHF and WD, consumption of both VHF/S and WD/S exaggerated insulin resistance, visceral obesity, and glucose intolerance. In addition, the ability of insulin to stimulate Akt phosphorylation and muscle glucose uptake was impaired in mice fed farmed salmon. Relative to VHF/S-fed mice, animals fed VHF/S-POPs had less body burdens of POPs, accumulated less visceral fat, and had reduced mRNA levels of TNFa as well as macrophage infiltration in adipose tissue. VHF/S-POPs-fed mice further exhibited better insulin sensitivity and glucose tolerance than mice fed VHF/S. Conclusions/Significance: Our data indicate that intake of farmed salmon fillet contributes to several metabolic disorders linked to type 2 diabetes and obesity, and suggest a role of POPs in these deleterious effects. Overall, these findings may participate to improve nutritional strategies for the prevention and therapy of insulin resistance

Self-Reported Access to Oral Health Care and Perception of Oral Health from 2011-2020

An individual’s perception of their oral cavity directly correlates with whether he/she will seek oral health care. Self-reported oral health (SROH) rating is typically measured on a scale of excellent to poor and is a validated measure of an individual’s oral health. This study aimed to (1) examine the correlation between SROH and access to oral health care, (2) assess changes in access and SROH from 2011 to 2020, and (3) analyze variations across age, gender, and race. Data was collected from the 2011-12, 2013-14, 2015-16, and 2017-20 National Health and Nutrition Examination Survey for individuals 20 or older. Two questions for the Oral Health Questionnaire were used: (1) rate the health of teeth and gums and (2) whether oral health care was available in the past 12 months when needed. Demographic data was collected. Data was uploaded to RStudio and analyzed for statistical significance. A significant correlation between SROH and access to care was found. No significant differences in mean SROH were observed across survey cycles (p = 0.27), and access to care did not significantly change over time (p = 0.1296). SROH varied by age, with individuals aged 30-64 reporting lower SROH and those 65+ more likely to report care access. Males reported lower SROH but higher access than females. Asian and White individuals reported higher SROH and access compared to other racial/ethnic groups. Future research should include the 2021-22 data to explore pandemic-related impacts on oral health perceptions and access and underlying factors affecting access

Acute Myeloid Leukemia Alters Group 1 Innate Lymphoid Cell Differentiation from a Common Precursor

Health Sciences: 3rd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)A three-year embargo was granted for this item

The Development of Music Expertise: Applications of the Theories of Deliberate Practice and Deliberate Play

Musicians and athletes share many common traits. Both groups learn a combination of physical and mental skills to attain expert status. In this literature review, I provide a short history of research on expertise development and two models: Bloom’s model of expertise development and the Developmental Model of Sport Participation. The Bloom model categorizes learning activities between combinations of free play and deliberate practice throughout the three stages of development. However, Developmental Model of Sport Participation includes a new category, deliberate play, which combines aspects of play and deliberate practice. Research indicating music learning through deliberate practice, deliberate play, and music play is presented. If students are able to learn through the more enjoyable deliberate play and music play, teachers should consider including these activities to better match developmental stages and potentially improve retention. Implications for future research and music teachers are discussed.</jats:p