Chronic thoracic hemisection spinal cord injury in adult rats induces a progressive decline in transmission from uninjured fibers to lumbar motoneurons

Although most spinal cord injuries are anatomically incomplete, only limited functional recovery has been observed in people and rats with partial lesions. To address why surviving fibers cannot mediate more complete recovery, we evaluated the physiological and anatomical status of spared fibers after unilateral hemisection (HX) of thoracic spinal cord in adult rats. We made intracellular and extracellular recordings at L5 (below HX) in response to electrical stimulation of contralateral white matter above (T6) and below (L1) HX. Responses from T6 displayed reduced amplitude, increased latency and elevated stimulus threshold in the fibers across from HX, beginning 1-2 weeks after HX. Ultrastructural analysis revealed demyelination of intact axons contralateral to the HX, with a time course similar to the conduction changes. Behavioral studies indicated partial recovery which arrested when conduction deficits began. These findings suggest a chronic pathological state in intact fibers and necessity for prompt treatment to minimize it

Candy Flavorings in Tobacco

Professor James F. Pankow reveals striking similarities between the patterns in the flavoring chemicals used in flavored tobacco products and those in popular candy and Kool-Aid products. The authors analyzed 12 artificially flavored candy and fruit drink products and compared them to 15 widely-available flavored tobacco products. They found significant overlap in the chemical signatures of the flavor chemicals. Several of the tobacco products contained flavor chemicals at much higher concentrations than in the non-tobacco products

Alien Registration- Lane, Lorne E. (Millinocket, Penobscot County)

https://digitalmaine.com/alien_docs/8100/thumbnail.jp

New Developments in Nova Scotia Psychiatric Legislation

Depsite advanced developments in the treatment of mental illness, Nova Scotia has until recently possessed some very archaic mental health legislation. The law treated the mentally ill patient differently depending on the institution in which he happened to be placed regardless of his diagnosis. Patients in general hospitals for psychiatric disorders fell within the jurisdiction of the Public Hospitals Act, and were treated no differently than physically ill patients. 1 Patients who were sent to the Nova Scotia Hospital, a psychiatric institution owned by the province fell within the Nova Scotia Hospital Act.2 It contained provisions on compulsory and voluntary admission, quite different from those under the Public Hospitals Act, where compulsory admission was not possible. The criteria for compulsory detention and treatment under the Nova Scotia Hospital Act were broad. It was necessary for the patient to be considered to have a mental disorder and that he should be admitted to the Nova Scotia Hospital, either because he required the in-patient facilities for observation, diagnosis or treatment, or that he required care that could not adequately be provided outside the hospital for his own health or safety, or for the protection of others. In addition, it was necessary that the patient, in the opinion of a medical practitioner, be certified because his mental status and lack of insight was such that he did not understand or was unwilling to accept the fact that he required admission to the hospital. Two medical certificates stating these factors were required

Kepler Eclipsing Binary Stars. VI. Identification of Eclipsing Binaries in the K2 Campaign 0 Data-set

The original {\it Kepler} mission observed and characterized over 2400 eclipsing binaries in addition to its prolific exoplanet detections. Despite the mechanical malfunction and subsequent non-recovery of two reaction wheels used to stabilize the instrument, the {\it Kepler} satellite continues collecting data in its repurposed {\it K2} mission surveying a series of fields along the ecliptic plane. Here we present an analysis of the first full baseline {\it K2} data release: the Campaign 0 data-set. In the 7761 light curves, we have identified a total of 207 eclipsing binaries. Of these, 97 are new discoveries that were not previously identified. Our pixel-level analysis of these objects has also resulted in identification of several false positives (observed targets contaminated by neighboring eclipsing binaries), as well as the serendipitous discovery of two short period exoplanet candidates. We provide catalog cross-matched source identifications, orbital periods, morphologies and ephemerides for these eclipsing systems. We also describe the incorporation of the K2 sample into the Kepler Eclipsing Binary Catalog\footnote{\url{keplerebs.villanova.edu/k2}}, present spectroscopic follow-up observations for a limited selection of nine systems, and discuss prospects for upcoming {\it K2} campaigns.Comment: Accepted for publication in MNRAS. 51 pages [20 figures, 8 tables]. Results available online in the Kepler Eclipsing Binary Star Catalog http://keplerebs.villanova.edu/k

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in the low-complexity domain (LCD) of T cell-restricted intracellular antigen-1 (TIA1). Subsequent genetic association analyses showed an increased burden of TIA1 LCD mutations in ALS patients compared to controls (p = 8.7 × 1

The Impact of Organizational Memory Information Systems on Organizational Learning

This paper reports on a case study of the organizational memory information system (OMIS) of an engineering group at a nuclear power plant. It found that the OMIS was effective based on the criteria of the competing values model (Quinn and Rohrbaugh, 1983). The engineering group was also considered to be effective based on the criteria used to evaluate effectiveness by the group managers. One of the criteria used to assess group effectiveness was the ability to use organizational memory and it was found that an improved OMIS resulted in improved organizational and individual effectiveness. The study also found that measurements of OMIS effectiveness could of been improved by refining the competing values model measurement of integration and by creating a measure for evaluating the reliance on individual\u27s memorie

Computer Skill Acquisition: The Effects of Computer-aided Self-explanation on Knowledge Retention and Transfer

We conducted an experimental study to determine to what extent computer skill learners can benefit from generating self-explanation with the aid of different computer-based visualization technologies. Self-explanation was stimulated with dynamic visualization (Screencast), static visualization (Screenshot), or verbal instructions only, and compared to a control group with no self-explanation instructions. Sixty-two subjects were assigned to these four conditions for learning HTML fundamentals. Two quizzes were used to test learning outcomes. In comparison to the control condition, performance was best with dynamic visualization and static visualization. The self-explanation condition without visualization did not attain statistical significance in comparison to the control condition. Qualitative data collected from a learning experience survey regarding the subjects’ opinions about self-explanation prompts showed that subjects in different treatment groups gave similar responses about how they benefited from self-explanation prompts for learning HTML