Cable Guys

The emergence of "male-centered serials" such as The Shield, Rescue Me, and Sons Of Anarchy and the challenges these characters face in negotiating modern masculinities. From the meth-dealing but devoted family man Walter White of AMC’s Breaking Bad, to the part-time basketball coach, part-time gigolo Ray Drecker of HBO’s Hung, depictions of male characters perplexed by societal expectations of men and anxious about changing American masculinity have become standard across the television landscape. Engaging with a wide variety of shows, including The League, Dexter, and Nip/Tuck, among many others, Amanda D. Lotz identifies the gradual incorporation of second-wave feminism into prevailing gender norms as the catalyst for the contested masculinities on display in contemporary cable dramas. Examining the emergence of “male-centered serials” such as The Shield, Rescue Me, and Sons of Anarchy and the challenges these characters face in negotiating modern masculinities, Lotz analyzes how these shows combine feminist approaches to fatherhood and marriage with more traditional constructions of masculine identity that emphasize men’s role as providers. She explores the dynamics of close male friendships both in groups, as in Entourage and Men of a Certain Age, wherein characters test the boundaries between the homosocial and homosexual in their relationships with each other, and in the dyadic intimacy depicted in Boston Legal and Scrubs. Cable Guys provides a much needed look into the under-considered subject of how constructions of masculinity continue to evolve on television

La evolución paradigmática de la televisión de EE.UU. y la aparición de la televisión distribuída por Internet

Television industries around the world have weathered profound change as technologies advanced and services developed to allow internet-distributed television to compete alongside broadcast and cable-distributed television. This article, drawn from the context of the U.S., explores the emergence of internet-distributed television as a mechanism that provides the affordance of nonlinear distribution. It assesses the preliminary organization of internet-distributed television by portals and explores the similarities and differences between portals and networks/channels with an eye toward conceptualizing emerging business practices and strategies.Las industrias de televisión de todo el mundo han resistido al profundo cambio que las tecnologías avanzadas y los servicios desarrollados que facilitan la distribución de television por Internet suponen como competencia de la distribución de televisión abierta y por cable. Este artículo, partiendo del contexto de los Estados Unidos, explora la aparición de la televisión distribuída por internet como un mecanismo que habilita y ofrece la distribución no lineal. Evalúa la organización inicial de la televisión distribuida por internet a través del análisis de portales y explora las similitudes y diferencias entre estos portales y las redes y canales, poniendo el foco en la conceptualización de las prácticas y estrategias de negocio emergentes

The One with the Feminist Critique: Revisiting Millennial Postfeminism with Friends

In the aftermath of its initial broadcast run, iconic millennial sitcom Friends (NBC, 1994–2004) generated some quality scholarship interrogating its politics of gender. But as a site of analysis, it remains a curious, almost structuring absence from the central canon of the first wave of feminist criticism of postfeminist culture. This absence is curious not only considering the place of Friends at the forefront of millennial popular culture but also in light of its long-term syndication in countries across the world since that time. And it is structuring in the sense that Friends was the stage on which many of the familiar tropes of postfeminism interrogated across the body of work on it appear in retrospect to have been tried and tested. This article aims to contribute toward redressing this absence through interrogation and contextualization of the series’ negotiation of a range of structuring tropes of postfeminist media discourse, and it argues for Friends as an unacknowledged ur-text of millennial postfeminism

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk

Beyond "quality television": the medium in other parts of the world

In a context in which cultural and industrial globalization is increasingly presented as a complex and paradoxical process whose main characteristic seems to be the tension and struggle between the local and the global, this discussion between experts in television from different parts of the world seeks to expand the geographical horizons of what we are talking about when we talk about production, distribution and reception of series of television to help us rethink the medium beyond the frontiers of «quality television»

Critical Media Industry Studies: A Research Approach

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73139/1/j.1753-9137.2009.01037.x.pd

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data