Outpatient 24-hour measurement of pulse wave velocity as a mortality predictor in hemodialysis patients, taking into account the follow-up examination after 6 years

In dieser Studie wurde das Potential der 24-Stundenmessung der Pulswellengeschwindigkeit (24h-PWV) als Mortalitätsprädiktor evaluiert. Die 24h-PWV wurde an 184 Patienten des ISAR-Studienkollektivs mithilfe von Mobil-O-Graphen gemessen. Die vorliegende Arbeit kommt zu dem Schluss, dass die 24h-PWV einen unabhängigen Mortalitätsprädiktor für die kardiovaskuläre und die Gesamtmortalität darstellt.In this study the potential of 24-hour measurements of the pulse wave velocity (24h-PWV) was evaluated as a measure to predict mortality. These measurements were done with Mobil-O-Graphs on 184 patients of the ISAR-study collective. 24h-PWV was found to represent an independent predictor of all-cause and cardiovascular mortality in hemodialysis patients

Comparison of 24-hour and Office Pulse Wave Velocity for Prediction of Mortality in Hemodialysis Patients

Background: Mortality in hemodialysis patients still remains unacceptably high. Enhanced arterial stiffness is a known cardiovascular risk factor, and pulse wave velocity (PWV) has proven to be a valid parameter to quantify risk. Recent studies showed controversial results regarding the prognostic significance of PWV for mortality in hemodialysis patients, which may be due to methodological issues, such as assessment of PWV in the office setting (Office-PWV). Method: This study cohort contains patients from the "Risk stratification in end-stage renal disease - the ISAR study," a multicenter prospective longitudinal observatory cohort study

Comparison of 24-hour and Office Pulse Wave Velocity for Prediction of Mortality in Hemodialysis Patients

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Mortality in hemodialysis patients still remains unacceptably high. Enhanced arterial stiffness is a known cardiovascular risk factor, and pulse wave velocity (PWV) has proven to be a valid parameter to quantify risk. Recent studies showed controversial results regarding the prognostic significance of PWV for mortality in hemodialysis patients, which may be due to methodological issues, such as assessment of PWV in the office setting (Office-PWV). &lt;b&gt;&lt;i&gt;Method:&lt;/i&gt;&lt;/b&gt; This study cohort contains patients from the “Risk stratification in end-stage renal disease – the ISAR study,” a multicenter prospective longitudinal observatory cohort study. We examined and compared the predictive value of ambulatory 24-hour PWV (24 h-PWV) and Office-PWV on mortality in a total of 344 hemodialysis patients. The endpoints of the study were all-cause and cardiovascular mortality. Survival analysis included Kaplan-Meier estimates and Cox regression analysis. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; During a follow-up of 36 months, a total of 89 patients died, 35 patients due to cardiovascular cause. Kaplan-Meier estimates for tertiles of 24 h-PWV and Office-PWV were similarly associated with mortality. In univariate Cox regression analysis, 24 h-PWV and Office-PWV were equivalent predictors for all-cause and cardiovascular mortality. After adjustment for common risk factors, only 24 h-PWV remained solely predictive for all-cause mortality (hazard ratio 2.51 [95% CI 1.31–4.81]; &lt;i&gt;p&lt;/i&gt; = 0.004). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Comparing both measurements, 24 h-PWV is an independent predictor for all-cause-mortality in hemodialysis patients beyond Office-PWV.</jats:p