From the organic thin film transistor to the 3-D textile organic cylindrical transistors - perspectives, expectations and predictions

In this paper we examine the possibility to simulate and study the behaviour of a fiber-based Textile Transistor in a commercial TCAD system. We also examine the capability of such transistors to operate in sufficiently low voltages, aiming to the potential realization of low-voltage wearable textiles in the future. We have seen that it is potentially feasible to build transistors which can operate in low voltages by using typical materials. Even if some of the selected typical materials have to be replaced by others more suitable for practical use in the textile industry, the simulation is a good starting point for estimating the device typical operation and parameters

Optimization of cylindrical textile organic field effect transistors using TCAD simulation tool

We used a commercial TCAD tool in order to simulate a cylindrical Textile Organic Field Effect Transistor (TOFET) and study the impact of different critical region sizes in its electrical characteristics. The simulation was based on models and parameters similar to those of previous simulations in Organic Thin Film Transistors. We have seen that it is potentially feasible to build transistors which can operate in low voltages by using typical materials. Even if some of the selected typical materials have to be replaced by others more suitable for practical use in the textile industry, the simulation is a good starting point for estimating the device typical operation and parameters. By optimizing critical region sizes of the device we conclude that the device should have an active layer thickness below 100 nm, channel length around 10 mu m and gate oxide thickness as small as possible (300 nm or less), in order to have optimum transistor performance

A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds

Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses. C5a triggers inflammatory responses by binding to its G-protein-coupled C5a-receptor (C5aR). Excessive or erroneous activation of the C5aR has been implicated in numerous inflammatory diseases. The C5aR is therefore a key target in the development of specific anti-inflammatory compounds. A very potent natural inhibitor of the C5aR is the 121-residue chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS). Although CHIPS effectively blocks C5aR activation by binding tightly to its extra-cellular N terminus, it is not suitable as a potential anti-inflammatory drug due to its immunogenic properties. As a first step in the development of an improved CHIPS mimic, we designed and synthesized a substantially shorter 50-residue adapted peptide, designated CHOPS. This peptide included all residues important for receptor binding as based on the recent structure of CHIPS in complex with the C5aR N terminus. Using isothermal titration calorimetry we demonstrate that CHOPS has micromolar affinity for a model peptide comprising residues 7–28 of the C5aR N terminus including two O-sulfated tyrosine residues at positions 11 and 14. CD and NMR spectroscopy showed that CHOPS is unstructured free in solution. Upon addition of the doubly sulfated model peptide, however, the NMR and CD spectra reveal the formation of structural elements in CHOPS reminiscent of native CHIPS

Analyse erfolgsprädiktiver Parameter bei der endoskopischen Stentbehandlung postoperativer Anastomoseinsuffizienzen im oberen Gastrointestinaltrakt

Selbsexpandierbare Metallstents (SEMS) werden zur Behandlung von Anastomoselecks nach gastroösophagealen Operationen eingesetzt. Prädiktoren für Behandlungsversagen und Komplikationen sind bisher unbekannt. In dieser retrospektiven Beobachtungsstudie fassen wir unsere Erfahrungen mit SEMS zur Behandlung von Anastomoselecks zusammen, um die Parameter für ein Versagen der Behandlung zu bestimmen. Zwischen 2009 und 2015 wurden insgesamt 356 Patienten aufgrund von einem Ösophagus- oder Magenkarzinom am oberen GI Trakt im Katharinenhospital, Klinikum Stuttgart operiert. In unserer Studie wurden 34 Patienten die untersucht die eine Therapie mit SEMS erhalten haben. Das mediane Alter betrug 66,5 Jahre. Die endoskopische Therapie mit SEMS war in 76,5 % der Patienten erfolgreich. Die meisten Patienten präsentierten sich histologisch mit einem Adenokarzinom. In 85 % der Fälle hatten die Patienten Komorbiditäten. Ein transthorakale Ösophagoektomie, erfolgte in 26 Fällen. Eine Gastrektomie erfolgte in 7 Fällen. Medianes Intervall zwischen Operationsdatum und Zeitpunkt der Diagnose der Anastomoseinsuffizienz war 7,5 Tage. Das 82 % der Patienten hatten als Insuffizienzgröße eine 1/3 Zirkumferenz. Insgesamt wurden 69 SEMS in 34 Patienten eingepflanzt. Die Durchmesser der Stents betrugen 20 bis 28 mm und die Länge war zwischen 80 bis 140 mm. Die mediane Stent Zahl pro Patienten betrugt 2,0 (Spanne 1-7 Stents). Die mediane Verweildauer der SEMS pro Patienten war 42 Tage (Zeitspanne 5-234). Geschlecht, Alter, Gewicht, Komorbidität, Lokalisations des Tumors, Histologie des Karzinoms, Neoadjuvante Chemotherapie, Anzahl der Chemotherapie Zyklen, Chemotherapie Substanzen, Lokale Strahlentherapie, OP Technik, Anastomoseinsuffizienzgröße, Zeitpunkt des Auftretens der Insuffizienz, Infektparameter, Anzahl der verwendeten SEMS, Stent Länge und Durchmesser, Stentverweildauer, Begleitende endoskopische Verfahren wurden auf ihren Vorhersagewerte gemäß Behandlungserfolg und Komplikationsrate analysiert. Signifikante Risikofaktoren für ein Versagen der Behandlung waren die Parameter neoadjuvante Chemostrahlentherapie, die Plattenepithelhistologie und die Lokalisation des Karzinoms. Bei 15 % der Patienten traten schwere stentbedingte Komplikationen auf. Es konnten keine Parameter identifiziert werden, die eine statistisch signifikante Rolle bei der Entstehung von Komplikationen spielen

SISTEM INFORMASI PENGARSIPAN SURAT MASUK DAN SURAT KELUAR PADA BALAI PENGEMBANGAN KEGIATAN BELAJAR YOGYAKARTA MENGGUNAKAN FRAMEWORK YII

Balai Pengembangan Kegiatan Belajar sebagai Unit Pelaksana Teknis yang bernaung di lingkungan Pemerintah Provinsi Daerah Istimewa Yogyakarta pada Dinas Pendidikan, Pemuda dan Olahraga Provinsi Daerah Istimewa Yogyakarta mempunyai tugas melaksanakan pengkajian, pengembangan, pendidikan, dll. Dalam melaksanakan tugas, Balai Pengembangan Kegiatan Belajar di bantu oleh sub bagian/seksi. Khususnya pada Sub bagian Tata Usaha mempunyai tugas melaksanakan kearsipan, keuangan, kepegawaian, dll. Dalam setiap tugas yang di jalankan khusunya di bidang kearsipan seringkali menghadapi permasalahan pada sistem pendataan surat masuk dan surat keluar. Untuk dapat mempermudah proses pendataan pengarsipan, membutuhkan sistem aplikasi berbasiskan web. Penelitian ini bertujuan untuk menerapkan sistem informasi Pengarsipan Surat Masuk dan Surat Keluar untuk menemukan permasalahan yang ada pada sistem yang sedang berjalan. Sistem akan dikembangkan dengan memanfaatkan teknologi web framework. Web framework digunakan agar sistem berbasis web lebih mudah dibangun, mudah dikembangkan, dan dapat menghemat waktu yang diperlukan dalam pengembangan sistem berbasis web. Web framework yang digunakan adalah Yii yang mendukung pola MVC (Model – View – Controller). Kata kunci : Framework Yii, Surat Masuk, Surat Keluar, Pengarsipa

Peptide Labeling with Isobaric Tags Yields Higher Identification Rates Using iTRAQ 4-Plex Compared to TMT 6-Plex and iTRAQ 8-Plex on LTQ Orbitrap

Peptide labeling with isobaric tags has become a popular technique in quantitative shotgun proteomics. Using two different samples viz. a protein mixture and HeLa extracts, we show that three commercially available isobaric tags differ with regard to peptide identification rates: The number of identified proteins and peptides was largest with iTRAQ 4-plex, followed by TMT 6-plex, and smallest with iTRAQ 8-plex. In all experiments, we employed a previously described method where two scans were acquired for each precursor on an LTQ Orbitrap: A CID scan under standard settings for identification, and a HCD scan for quantification. The observed differences in identification rates were similar when data was searched with either Mascot or Sequest. We consider these findings to be the result of a combination of several factors, most notably prominent ions in CID spectra as a consequence of loss of fragments of the label tag from precursor ions. These fragment ions cannot be explained by current search engines and were observed to have a negative impact on peptide scores