An open-label, phase IV randomised controlled trial of two schedules of a four-component meningococcal B vaccine in UK preterm infants

Objective: To compare immunological responses of preterm infants to a four-component meningococcal B vaccine (4CMenB; Bexsero) following a 2+1 vs a 3+1 schedule, and to describe reactogenicity of routine vaccines. Design: An open-label, phase IV randomised study conducted across six UK sites. Setting: Neonatal units, postnatal wards, community recruitment following discharge. Participants: 129 preterm infants born at a gestation of 38.0°C than those in the 2+1 group who did not (group 2+1: 2% (n=1); 3+1: 14% (n=9); p=0.02). Conclusions: Both schedules were immunogenic in preterm infants, although a lower response against strain NZ98/254 was seen in the 2+1 schedule; ongoing disease surveillance is important in understanding the clinical significance of this difference. Trial registration number: NCT03125616

An open-label, phase IV randomised controlled trial of two schedules of a four-component meningococcal B vaccine in UK preterm infants

Objective: To compare immunological responses of preterm infants to a four-component meningococcal B vaccine (4CMenB; Bexsero) following a 2+1 vs a 3+1 schedule, and to describe reactogenicity of routine vaccines.   Design: An open-label, phase IV randomised study conducted across six UK sites.   Setting: Neonatal units, postnatal wards, community recruitment following discharge.   Participants: 129 preterm infants born at a gestation of 38.0°C than those in the 2+1 group who did not (group 2+1: 2% (n=1); 3+1: 14% (n=9); p=0.02).   Conclusions: Both schedules were immunogenic in preterm infants, although a lower response against strain NZ98/254 was seen in the 2+1 schedule; ongoing disease surveillance is important in understanding the clinical significance of this difference.   Trial registration number NCT03125616

HARMONI at ELT: project status and instrument overview

International audienceHARMONI is the first light visible and near-IR integral field spectrograph for the ELT. It covers a large spectral range from 450 nm to 2450 nm with resolving powers from 3500 to 18000 and spatial sampling from 60 mas to 4 mas. It can operate in two Adaptive Optics modes - SCAO (including a High Contrast capability) and LTAO - or with NOAO. The project is preparing for Final Design Reviews. HARMONI is a work-horse instrument that provides efficient, spatially resolved spectroscopy of extended objects or crowded fields of view. The gigantic leap in sensitivity and spatial resolution that HARMONI at the ELT will enable promises to transform the landscape in observational astrophysics in the coming decade. The project has undergone some key changes to the leadership and management structure over the last two years. We present the salient elements of the project restructuring, and modifications to the technical specifications. The instrument design is very mature in the lead up to the final design review. In this paper, we provide an overview of the instrument's capabilities, details of recent technical changes during the red flag period, and an update of sensitivities

Introducing eastern orthodox theology

xx, 172 p.; 23 cm

Holiness and Sanctity in the Early Church

In 1971 Peter Brown published his justly famous article, ‘The Rise and Function of the Holy Man in Late Antiquity’. It is no exaggeration to say that this article — and the host of articles and books that succeeded it — have transformed the way we think about saints and their cult in late antiquity. This change is part of a wider transformation of the study of the world of early Christianity, a change that has much to do with the changing, not to say declining, place of Christianity in Western society. The very words Peter Brown used in the title of his article are emblematic of this changed perspective: holy, man, late antiquity. Others have noted the change of words from what one might have expected, or from what one would have expected a few decades, even years, earlier. Averil Cameron spoke of Peter Brown ‘rightly avoiding the term “saint”, for in this early period there were no formal processes of sanctification, and no official bestowal of sainthood’. Put like that, it seems obvious why Brown talked about the ‘holy man’. I want to suggest that the nature of the change involved is much less easy to track down, and furthermore that awareness of the specific suggestions implicit in Brown’s choice of words will enable us to contemplate the world of late antiquity from the perspective Brown was largely inaugurating, while not losing the other perspectives that were implicit in the language and concepts laid aside.</jats:p